Objectives To investigate clinic significance of serum level of calcitonin gene related peptide （CGRP） in patients with thrombosis of iliac and femoral venous （TIFV）. Methods CGRP levels of fifty patients with TIFV were analyzed

and changes of CGRP before and after use of urokinase combined with Fufangdanshen Injection were detected. Results High serum levels of CGRP were detected in acute TIFV patients and there was significant difference between two groups. After treatment CGRP levels of the patients increased in 6 hours

reached peaks in 3 days and regained normal levels in 15 days. Conclusion CGRP may be one of diagnostic indexes of patients with TIFV. It is effective to combine urokinase with Fufangdanshen Injection for curing the disease.