objective To observe the clinical effect of Tianmagouteng Granules on treating infantil Gilles de la Tourette Syndrome. Method Ninety-five diagnosed cases of Gilles de la Tourette Syndrome were randomly divided into two groups. The treatment group （50 cases） was given Tianmagouteng Granules and the control group （45 cases） was given Jingling Oral Solution. They were compared at the end of treating courses. Result There was significant difference in clinical effects （P<0.05） and symptom reliefs in two groups （P<0.05）. Conclusion Tianmagouteng Granules can relieve obviously the symptoms of Gilles de la Tourette Syndrome.