Clinical observation of modified <italic style="font-style: italic">Diyu</italic> Powder for oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment

Zhaowen Peng; Peng Liu; Shujing Yi; Xuan Tu; Yuantao Zhong; Yang Jiang; Gaofei Feng; Hailing You; Kaiwen Hu

doi:10.3969/j.issn.2095-6606.2021.05.008

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Clinical observation of modified Diyu Powder for oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment

更新时间：2021-10-19

- Clinical observation of modified Diyu Powder for oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment
- Modern Chinese Clinical Medicine Vol. 28, Issue 5, Pages: 34-37(2021)
- 作者机构：
  
  1.北京中医药大学深圳医院(龙岗) 　广东　 518100
  2.北京中医药大学东方医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2021.05.008
  CLC： R273
- Published：30 September 2021，
  
  Received：25 July 2020，
- 稿件说明：
移动端阅览
Zhaowen Peng, Peng Liu, Shujing Yi, et al. Clinical observation of modified Diyu Powder for oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment. [J]. Modern Chinese Clinical Medicine 28(5):34-37(2021)
DOI：

Zhaowen Peng, Peng Liu, Shujing Yi, et al. Clinical observation of modified Diyu Powder for oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment. [J]. Modern Chinese Clinical Medicine 28(5):34-37(2021) DOI： 10.3969/j.issn.2095-6606.2021.05.008.

摘要

目的

观察加味地榆散对肺癌靶向治疗患者口腔黏膜炎阴虚热毒证的临床疗效。

方法

将50例肺癌靶向治疗口腔黏膜炎患者随机分为治疗组25例、对照组25例。治疗组在常规治疗基础上予口服加味地榆散治疗，对照组在常规治疗基础上予复方氯己定治疗。观察2组口腔黏膜炎分级、中医证候积分、卡氏行为状态评分(Karnofsky’s performance scale，KPS)。

结果

2组治疗后口腔黏膜炎分级比较差异有统计学意义(

0.05)，治疗组改善情况优于对照组。2组中医证候积分治疗后较本组治疗前均降低(

0.01)，治疗组较对照组降低明显，2组治疗前后差值比较，差异有统计学意义(

0.01)，治疗组优于对照组。治疗组治疗前后KPS评分比较差异有统计学意义，生活质量改善；2组治疗前后KPS评分比较，差异均有统计学意义(

0.05)。

结论

加味地榆散治疗肺癌靶向治疗患者的口腔黏膜炎阴虚热毒证具有较好的临床疗效。

Abstract

Objective

To observe the therapeutic effect of modified

Diyu

Powder in the treatment of oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment.

Methods

Fifty lung cancer patients with oral mucositis were randomly divided into the experimental group and control group

25 cases in each group. The control group received compound chlorhexidine combined with routine treatment

and the experimental group took modified

Diyu

powder orally. The classification of oral mucositis

the TCM syndrome score and Karnofsky’s performance scale(KPS) were observed in the two groups.

Results

The classification of oral mucositis was lower after treatment than before treatment in both groups(

0.05)

with better improvement in the treatment group than in the control group. The scores of TCM syndromes were lower after treatment than before treatment in both groups(

0.01)

significantly lower in the treatment group than in the control group. There was a significant before-after-treatment difference in KPS in the treatment group(

0.01)

and there was a significant before-after-treatment difference in KPS between the treatment group and the control group (

0.05).

Conclusions

Modified

Diyu

Powder can improve the reaction of oral mucositis and the quality of life of lung cancer patients.

关键词

加味地榆散肺癌靶向治疗口腔黏膜炎生活质量

Keywords

modified Diyu powderlung cancertargeted therapyoral mucositisquality of life

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⁰

Clinical observation of modified Diyu Powder for oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment

DOI：10.3969/j.issn.2095-6606.2021.05.008

摘要

Abstract

关键词

Keywords

references