Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine

Yuhan Fan; Liqing Shi; Jianling Ma; Liyun Wang; Kun Ji; Ying Wang; Jingyue Luo

doi:10.3969/j.issn.2095-6606.2021.05.015

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Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine

更新时间：2021-10-19

- Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine
- Modern Chinese Clinical Medicine Vol. 28, Issue 5, Pages: 65-68(2021)
- 作者机构：
  
  1.北京中医药大学　北京　 100029
  2.北京中医药大学东方医院
  3.浙江省中医院
  4.首都医科大学附属北京胸科医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2021.05.015
  CLC： R256.11
- Published：30 September 2021，
  
  Received：11 May 2021，
- 稿件说明：
移动端阅览
Yuhan Fan, Liqing Shi, Jianling Ma, et al. Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine. [J]. Modern Chinese Clinical Medicine 28(5):65-68(2021)
DOI：

Yuhan Fan, Liqing Shi, Jianling Ma, et al. Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine. [J]. Modern Chinese Clinical Medicine 28(5):65-68(2021) DOI： 10.3969/j.issn.2095-6606.2021.05.015.

摘要

临床常见寒冷刺激诱发的慢性咳嗽。历代医家强调久咳病因多为瘀、寒、风、虚等，以及内、外寒共同作用导致慢性咳嗽寒咳证。本团队认为寒冷刺激诱发慢性咳嗽寒咳证具有内外合邪、脏腑相关、虚实夹杂的病机特点。瞬时受体电位A1(transient receptor potential ankyrin 1，TRPA1)和瞬时受体电位M8(transient receptor potential melastatin 8，TRPM8)冷感觉通道参与导致机体咳嗽敏感性增高的多个环节，可能是慢性咳嗽寒咳证发病的重要物质基础之一。

Abstract

Chronic cough induced by cold stimulation is common clinically. TCM physicians of all dynasties have emphasized that the etiology of prolonged cough is mostly stasis

cold

wind

deficiency

as well as coordinated work of internal and external colds. Our research team believes that cold cough induced by cold stimulation is characterized by internally and externally combined pathogens

zang

organ relevance

and deficiency-excess complex. Transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential melastatin 8(TRPM8) cold sensory channels are involved in many links leading to the increased cough sensitivity

which may be one of the material bases for the pathogenesis of cold cough of chronic cough.

关键词

寒冷刺激慢性咳嗽寒咳病因病机瞬时受体电位通道

Keywords

cold stimulationchronic coughcold coughetiology and pathogenesistransient receptor potential channel

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