Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome

Xue’er Yan; Jie Li; Fengzhi Wu; Yingyu Jia; Guangyao Chen; Sisi Zheng; Yan Liu; qin Zhou; Xiaobo Ge; Feng Li; Yuehan Song

doi:10.3969/j.issn.2095-6606.2021.06.009

您当前的位置：

首页 >

文章列表页 >

Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome

更新时间：2021-12-06

- Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome
- Modern Chinese Clinical Medicine Vol. 28, Issue 6, Pages: 41-45(2021)
- 作者机构：
  
  1.北京中医药大学　北京　100029
  2.中国中医科学院望京医院
  3.首都医科大学附属北京安定医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2021.06.009
  CLC： R272.6
- Published：30 November 2021，
  
  Received：21 March 2021，
- 稿件说明：
移动端阅览
Xue’er Yan, Jie Li, Fengzhi Wu, et al. Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome. [J]. Modern Chinese Clinical Medicine 28(6):41-45(2021)
DOI：

Xue’er Yan, Jie Li, Fengzhi Wu, et al. Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome. [J]. Modern Chinese Clinical Medicine 28(6):41-45(2021) DOI： 10.3969/j.issn.2095-6606.2021.06.009.

摘要

目的

基于数据挖掘探讨徐荣谦教授治疗多发性抽动症的组方规律，以及以温胆汤为主方的疗效评价研究。

方法

纳入东直门医院符合多发性抽动症诊断标准的首诊病例157例，基于关联规则分析用药规律。纳入30例符合《精神疾病诊断与统计手册》(DSM-IV-TR)的多发性抽动症患者，经徐荣谦教授辨证后开具以温胆汤为基础方的方药，收集并对比治疗前后患者的耶鲁综合抽动严重程度量表(yale global tic severityb scale

YGTSS)评分。

结果

对157例患者选用方药关联结果进行分析，置信度及支持度较高的配伍主要集中在温胆汤的药物，多配合使用镇肝息风药物石决明、生龙齿、钩藤以及养心安神药物炒酸枣仁、蕤仁。30例患者治疗后YGTSS总分及各子项包括次数、频率、强度、复杂性、干扰、缺损的得分均低于治疗前，差异具有统计学意义（

0.05）。

结论

以温胆汤为基础方治疗多发性抽动症具有较好的临床疗效。

Abstract

Objective

To explore Prof. Xu Rongqian’s prescription rules in the treatment of Tourette Syndrome(TS)based on data mining and to explore the curative effect evaluation study of

Wendan

Decoction as the main prescription.

Methods

One hundred and fifty-seven first-diagnosed cases that met the diagnostic criteria were included

and Professor Xu’s medication rules were explored based on association rules. Thirty patients diagnosed as having TS by using Diagnostic and Statistical Manual of Mental Disorders(DSM-IV-TR) were treated with herb formulas based on Professor Xu Rongqian’s application of modified

Wendan

Decoction.The scores of The Yale Global Tic Severity Scale(YGTSS) before and after treatment were observed.

Results

The association of prescriptions and medicines selected by 157patients was analyzed

The compatibility with higher confidence and support was mainly concentrated on the medicines of

Wendan

Decoction

and the combined use of the live-calming and wind-relieving medicinals

for example

shijueming

(Concha Haliotidis)

sheng longchi

( raw Dens Draconis)

gouteng

(Ramulus Uncariae Cum Uncis)andmind-tranquilizing medicinals such as

chao suanzaoren

(fried Semen Ziziphi Spinosae) and

ruiren

(Nux Prinsepiae).The total score and six dimensions including number

frequency

intensity

complexity

interference and damage scores of YGTSS were all significantly lower after treatment than before treatment(

0.05).

Conclusions

Professor Xu’s application of modified

Wendan

Decoction as basic herb formulas has a good effect in the treatment of Tourette Syndrome.

关键词

徐荣谦多发性抽动症温胆汤耶鲁综合抽动严重程度量表关联分析

Keywords

Xu RongqianTourette SyndromeWendan Decoctionthe Yale Global Tic Severity Scaleassociation rules

references

ABIJAOUDE E, GORMAN DA. Tourette syndrome[J]. CMAJ, 2013,185(3):236.

RIZZOR , GULISANO M, CALì P V, et al. Tourette Syndrome and comorbid ADHD: current pharmacological treatment options[J].Eur J Paediatr Neurol，2013:17(5): 421-428.

MORAND-BEAULIEU S, LECLERC J B, VALOIS P, et al. A Review of the Neuropsychological Dimensions of Tourette Syndrome[J]. Brain Sciences, 2017, 7(12):106.

DABROWSKI J, KING J, Edwards K, et al.The Long-Term Effects of Group-Based Psychological Interventions for Children With Tourette Syndrome: A Randomized Controlled Trial[J]. Behav Ther, 2018:331-343.

HORNIG M, LIPKIN W I. Immune-mediated animal models of Tourette syndrome[J]. Neuroscience & Biobehavioral Reviews, 2013, 37(6):1120-1138.

QUEZADA J, COFFMAN K A. Current Approaches and New Developments in the Pharmacological Management of Tourette Syndrome[J]. Cns Drugs, 2018, 32(1):33-45.

BALDERMANN J C, Schüller T, HUYS D, etal. Deep Brain Stimulation for Tourette-Syndrome: A Systematic Review and Meta-Analysis[J]. Brain Stimulation, 2016, 9(2):296-304.

罗燕,杨华,林炜.不同药物治疗多发性抽动症患儿的临床效果比较[J].临床合理用药杂志,2018,11(29):16-17.

张婷,王有鹏.中医治疗儿童多发性抽动症研究进展[J].实用中医药杂志,2018,34(1):127-130.

别涛,阎兆君.儿童抽动症的中医辨治研究进展[J].湖北中医杂志,2018,40(12):53-57.

徐荣谦,孙洮玉.刘弼臣教授治疗多发性抽动症的经验撷萃[J].北京中医药大学学报(中医临床版),2006,13(6):32-33.

史文丽,徐荣谦.徐荣谦教授活用温胆汤治疗小儿神经精神系统疾病[J].吉林中医药,2014,34(7):668-670.

SCAHILL L D . Yale Global Tic Severity Scale[M]. New York: Springer, 2013.

刘弼臣,王俊宏,陈丹,等.中医药治疗抽动秽语综合征临床研究述评[J].北京中医药大学学报,1996,19(6):2-6.

HALLETT M. Tourette Syndrome: Update[J]. Brain and Development, 2015, 37(7):651-655.

NOMURA Y. Tourette Syndrome: Clinical Features and Pathophysiology[J]. Brain Nerve, 2017, 69(12):1373-1385.

刘燕,宋月晗,陈光耀,等.徐荣谦对小儿多发性抽动症的辨治经验介绍[J].中国医药导报,2019,16(24):139-142.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Professor Xu Rongqian’s experience in treating epilepsy in children from the perspective of the gallbladder

Effects of Jian-Pi-Zhi-Dong Decoction on hypothalamic pituitary adrennal axis of children with Tourette Syndrome

Related Author

Haiyin FENG

Ruiping WANG

Rongqian XU

CUI Xia

YU Wenjing

ZHANG Wen

HU Lijun

NIU Yan

Related Institution

Dongzhimen Hospital, Beijing University of Chinese Medicine

Third Affiliated Hospital of Beijing University of Chinese Medicine

Dongfang Hospital, Beijing University of Chinese Medicine

⁰