TCM prescription rules and potential mechanism of chronic fatigue syndrome based on data mining and network pharmacology<sup>*</sup>

Yifei ZHANG; Fengzhi WU; Zehan ZHANG; Dandan SONG; Xiaowen YUN; Xuejiao WANG; Feng LI

doi:10.3969/j.issn.2095-6606.2022.01.011

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TCM prescription rules and potential mechanism of chronic fatigue syndrome based on data mining and network pharmacology^*

更新时间：2022-01-30

- TCM prescription rules and potential mechanism of chronic fatigue syndrome based on data mining and network pharmacology^*
- Modern Chinese Clinical Medicine Vol. 29, Issue 1, Pages: 51-59(2022)
- 作者机构：
  
  1.北京中医药大学中医学院　北京　102488
  2.北京中医药大学期刊中心
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.01.011
  CLC： R259
- Published：30 January 2022，
  
  Received：12 July 2021，
- 稿件说明：
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Yifei ZHANG, Fengzhi WU, Zehan ZHANG, et al. TCM prescription rules and potential mechanism of chronic fatigue syndrome based on data mining and network pharmacology^*. [J]. Modern Chinese Clinical Medicine 29(1):51-59(2022)
DOI：

Yifei ZHANG, Fengzhi WU, Zehan ZHANG, et al. TCM prescription rules and potential mechanism of chronic fatigue syndrome based on data mining and network pharmacology^*. [J]. Modern Chinese Clinical Medicine 29(1):51-59(2022) DOI： 10.3969/j.issn.2095-6606.2022.01.011.

摘要

目的

挖掘中医药治疗慢性疲劳综合征(CFS)的组方用药规律，并探讨其核心配伍组“黄芪—党参—白术—当归”的潜在作用机制。

方法

以中国知网、万方、维普等数据库收录的学术期刊文献为资料来源，使用Excel 2019进行文献收集和筛选，再应用古今医案云平台V 2.3，SPSS Statistics 26.0和SPSS Modeler 18.0软件，对标准化的中药进行频数与属性统计、关联规则、系统聚类和因子分析，运用网络药理学方法对核心配伍组进行KEGG通路分析，探讨其潜在作用机制。

结果

在纳入的307个临床组方中，中药黄芪最为常见，药性以温、平为主，药味以甘、辛为主，归经中脾经最多。关联规则分析结果显示：14种关联强度较高的配伍组，“黄芪—党参—白术—当归”药物组合置信度最高，因子分析中提取得到7个公因子，系统聚类分析中将药物归为5大类。KEGG通路分析发现“黄芪—党参—白术—当归”核心配伍组富集到的主要生物学通路共166条，其中TNF信号通路、PI3k-Akt信号通路、HIF-1信号通路等通路与核心配伍组治疗CFS的关系较为密切。

结论

CFS的中医药治疗以理气健脾、养血补虚为主，临床使用黄芪、茯苓、当归、白术等组合用药，并随证配伍补肾填精、理气解郁、养心安神之品。“黄芪—党参—白术—当归”核心配伍组可能通过TNF信号通路、PI3k-Akt信号通路、HIF-1信号通路等相关信号通路，作用于AKT1，MAPK8，IL6，MAPK1和JUN等靶点，从而发挥治疗CFS的作用。

Abstract

Objective

To explore the TCM prescription rules in the treatment of chronic fatigue syndrome (CFS) and its potential mechanism of core compatibility of "

Huangqi

Dangshen

Baizhu

Danggui

" .

Methods

The data were from CNKI

Wanfang

and VIP databases and recorded in Excel 2019. The Ancient and Modern Medical Records Cloud Platform V2.3

SPSS Statistics 26.0

and SPSS Modeler 18.0 were used for frequency and attribute calculation

association rules

systematic clustering and factor analysis after standardizing Chinese herbal medicines. The KEGG pathway analysis of core compatibility group was conducted by using network pharmacology to explore its potential mechanism.

Results

Among the included 307 clinical prescriptions

Huangqi

(Radix Astragali) was the most commonly used

mainly with warm and neutral properties

sweet and acrid flavors. It is attributive mainly to the Spleen Meridian. Association rule analysis screened out 14 herbal compatibility groups in high strength

such as "

Huangqi

Dangshen

Baizhu

Danggui

" . Seven common factors were extracted by factor analysis

and herbs were classified into five categories in systematic clustering analysis. KEGG pathway analysis showed that a total of 166 main biological pathways were enriched in the core compatibility group of "

Huangqi

Dangshen

Baizhu

Danggui

among which the TNF signal pathway

PI3K-Akt signal pathway

HIF-1 signal pathway were closely related to CFS treatment.

Conclusions

TCM treatment for CFS mainly rectifies qi and fortifies the spleen

and nourishes blood and tonifies deficiency.

Huangqi

Fuling

Danggui

and

Baizhu

are frequently used in clinical practice

and combined with herbs with the actions of tonifying the kidney and supplementing essence

rectifying qi to resolve constraint

nourishing the heart and calming the mind based on specific syndromes. The core compatibility group of "

Huangqi

Dangshen

Baizhu

Danggui

" may act on targets such as Akt1

MAPK8

IL6

MAPK1

and JUN via TNF signal pathway

PI3K-Akt signal pathway

and HIF-1 signal pathway

thus exerting effects on the treatment of chronic fatigue syndrome.

关键词

慢性疲劳综合征数据挖掘网络药理学用药规律作用机制

Keywords

chronic fatigue syndromedata miningnetwork pharmacologymedication rulesmechanism

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