Evaluation of clinical efficacy and safety of acupuncture combined with acupoint application in the treatment of malignant bowel obstruction

Peng LIU; Lianyang XU; Zhaowen PENG; Xuan TU; Jinlan HUANG; Yuantao ZHONG; Shujing YI; Gaofei FENG; Yang CAO

doi:10.3969/j.issn.2095-6606.2022.02.003

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Evaluation of clinical efficacy and safety of acupuncture combined with acupoint application in the treatment of malignant bowel obstruction

更新时间：2022-04-02

- Evaluation of clinical efficacy and safety of acupuncture combined with acupoint application in the treatment of malignant bowel obstruction
- Modern Chinese Clinical Medicine Vol. 29, Issue 2, Pages: 13-18(2022)
- 作者机构：
  
  1.北京中医药大学深圳医院(龙岗)　深圳　518172
  2.广州中医药大学第一临床医学院
  3.广州中医药大学针灸推拿学院
  4.广州中医药大学第一附属医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.02.003
  CLC： R273
- Published：30 March 2022，
  
  Received：19 March 2021，
- 稿件说明：
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Peng LIU, Lianyang XU, Zhaowen PENG, et al. Evaluation of clinical efficacy and safety of acupuncture combined with acupoint application in the treatment of malignant bowel obstruction. [J]. Modern Chinese Clinical Medicine 29(2):13-18(2022)
DOI：

Peng LIU, Lianyang XU, Zhaowen PENG, et al. Evaluation of clinical efficacy and safety of acupuncture combined with acupoint application in the treatment of malignant bowel obstruction. [J]. Modern Chinese Clinical Medicine 29(2):13-18(2022) DOI： 10.3969/j.issn.2095-6606.2022.02.003.

摘要

目的

观察针刺联合穴位贴敷治疗恶性肠梗阻(MBO)的临床疗效及安全性。

方法

将60例MBO患者随机分为治疗组30例、对照组30例。对照组予常规对症支持治疗，治疗组在对照组治疗的基础上，采用针刺联合穴位贴敷治疗。观察总体疗效、卡氏(KPS)功能状态评分疗效、梗阻症状评分、生活质量评分，并进行安全性评价。

结果

2组总体疗效比较，治疗组30例中完全缓解9例，好转19例，无效2例，总有效率为93.3%；对照组30例中完全缓解3例，好转18例，无效9例，总有效率为70.0%。经秩和检验，

＝－2.686，

＝0.007，

0.05，说明治疗组总体疗效优于对照组。2组KPS功能状态评分疗效比较，治疗组30例中提高21例，有效5例，稳定4例，无效0例，总有效率为86.7%；对照组30例中提高13例，有效10例，稳定2例，无效5例，总有效率为76.7%。经秩和检验，

＝－2.106，

＝0.035，

0.05，说明治疗组KPS功能状态评分疗效优于对照组。梗阻症状评分2组治疗后较本组治疗前均提高(

0.05)，治疗后治疗组较对照组提高明显，2组治疗前后差值比较，差异有统计学意义(

0.05)，治疗组优于对照组。生活质量评分2组治疗后较本组治疗前均提高(

0.05)，治疗后治疗组较对照提高明显，2组前后差值比较，差异有统计学意义(

0.05)，治疗组优于对照组。治疗期间2组均未出现严重不良反应。

结论

针刺联合穴位贴敷治疗MBO具有较好的临床疗效。

Abstract

Objective

To evaluate the clinical efficacy and safety of acupoint acupuncture combined with acupoint application in the treatment of malignant bowel obstruction (MBO).

Methods

Sixty participants with MBO were randomly enrolled into the treatment group (

=30) and control group (

=30). Conventional symptomatic supportive treatment was applied to the control group while the acupuncture combined with acupoint application was given to the treatment group on the basis of symptomatic treatment. The overall clinical efficacy

Karnofsky (KPS) functional status score efficacy

obstruction symptom score

quality of life (QOL) score and safety of the 2 groups were evaluated.

Results

As for the overall efficacy

9 cases were completely relieved

19 cases were improved

and 2 cases were ineffective

with a total effective rate of 93% in the treatment group. In the control group

3 cases were completely relieved

18 cases improved

and 9 cases were ineffective

with a total effective rate of 70%. Nonparametric test showed that as compared with the control group

acupoint acupuncture combined with acupoint application had advantages in clinical effects (

=-2.686

=0.007

0.05). Efficacy of KPS functional status scores was compared between the two groups. Among the 30 cases in the treatment group

21 cases were improved

5 cases were effective

4 cases were stable

and 0 case was ineffective

with a total effective rate of 86.7%. In the control group

13 cases were increased

10 cases were effective

2 cases were stable

and 5 cases were invalid

with a total effective rate of 76.7%. Nonparametric test showed that KPS functional status score efficacy was better in the treatment group than in the control group (

=-2.106

=0.035

0.05). The score of obstruction symptoms in both groups was improved after treatment

as compared with before treatment (

0.05)

and the score in the treatment group was improved significantly

as compared with the control group. The difference between the two groups before and after treatment was statistically significant (

0.05)

more in the treatment group than in the control group. In terms of QOL score

both groups were improved after treatment compared with before treatment. QOL score was more significantly improved in the treatment group than in the control group (

0.05)

indicating that the treatment group was superior to the control group. No serious adverse reactions occurred in both groups during treatment.

Conclusions

The combination of acupuncture and acupoint application shows good clinical effects in the treatment of MBO.

关键词

恶性肠梗阻中医外治法针刺穴位贴敷多模式理念姑息治疗

Keywords

malignant bowel obstruction (MBO)external therapies of TCMacupunctureacupoint applicationmulti-mode conceptpalliative treatment

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