Treatment of IgA nephropathy based on the gut-kidney axis in traditional Chinese and Western medicine

Hang GAO; Yazhou ZHAO; Chunying LIU

doi:10.3969/j.issn.2095-6606.2022.02.017

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Treatment of IgA nephropathy based on the gut-kidney axis in traditional Chinese and Western medicine

更新时间：2022-04-02

- Treatment of IgA nephropathy based on the gut-kidney axis in traditional Chinese and Western medicine
- Modern Chinese Clinical Medicine Vol. 29, Issue 2, Pages: 72-76(2022)
- 作者机构：
  
  1.陕西中医药大学　咸阳　712046
  2.陕西中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.02.017
  CLC： R256.5
- Published：30 March 2022，
  
  Received：24 November 2020，
- 稿件说明：
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Hang GAO, Yazhou ZHAO, Chunying LIU. Treatment of IgA nephropathy based on the gut-kidney axis in traditional Chinese and Western medicine. [J]. Modern Chinese Clinical Medicine 29(2):72-76(2022)
DOI：

Hang GAO, Yazhou ZHAO, Chunying LIU. Treatment of IgA nephropathy based on the gut-kidney axis in traditional Chinese and Western medicine. [J]. Modern Chinese Clinical Medicine 29(2):72-76(2022) DOI： 10.3969/j.issn.2095-6606.2022.02.017.

摘要

IgA肾病是目前最常见的原发性肾小球疾病。近年来，肠道微生物群与IgA肾病(肠道－肾脏轴)之间的致病关联引起医学界的广泛关注。西医认为肠道微生物群是尿毒症毒素的一个潜在来源，肠道上皮屏障功能失调和肠道微生物群失调均会加速IgA肾病的进展。治疗上应调节肠道微生物群、应用新型治疗方法等。中医认为邪气侵袭与正气损伤是导致IgA肾病发生的两方面因素，并根据IgA肾病的病程特点将其分为急性发作期和慢性维持期，急性发作期，应通腑祛邪，慢性维持期，应顾护正气。

Abstract

IgA nephropathy is the most common primary glomerular disease. The pathogenic association between the gut microbiota and IgA nephropathy (gut-kidney axis) has attracted much medical attention in recent years. Western medicine considers the gut microbiota as a potential source of toxins in uremia

and both dysfunction of the intestinal epithelial barrier and dysbiosis of the gut microbiota accelerate the progression of IgA nephropathy. Accordingly

treatment should include regulation of the intestinal microbiota and application of new therapeutic methods. Traditional Chinese medicine believes that the attack of pathogenic qi and the damage of healthy qi are the two factors that lead to the development of IgA nephropathy

and according to the characteristics of the course of IgA nephropathy

it is divided into the acute attack phase and the chronic maintenance phase. During acute attacks

bowels are supposed to be unblocked to expel the pathogenic factors

while during chronic maintenance

the healthy Qi should be protected.

关键词

IgA肾病肠肾轴肠道微生物中医西医

Keywords

IgA nephropathygut-kidney axisgut microbestraditional Chinese medicineWestern medicine

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