The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen

Yanan LIU; Danni WANG; Pengyu LI; Lihua CHEN; Huijun GUO

doi:10.3969/j.issn.2095-6606.2022.03.008

您当前的位置：

首页 >

文章列表页 >

The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen

更新时间：2022-06-02

- The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen
- Modern Chinese Clinical Medicine Vol. 29, Issue 3, Pages: 34-38(2022)
- 作者机构：
  
  1.河南中医药大学　郑州　450046
  2.河南中医药大学第一附属医院
  3.河南省中医药防治艾滋病临床研究中心
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.03.008
  CLC： R259
- Published：30 May 2022，
  
  Received：18 February 2021，
- 稿件说明：
移动端阅览
Yanan LIU, Danni WANG, Pengyu LI, et al. The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen. [J]. Modern Chinese Clinical Medicine 29(3):34-38(2022)
DOI：

Yanan LIU, Danni WANG, Pengyu LI, et al. The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen. [J]. Modern Chinese Clinical Medicine 29(3):34-38(2022) DOI： 10.3969/j.issn.2095-6606.2022.03.008.

摘要

艾滋病(AIDS)因其具有高度传染性和不可治愈性，是目前严重威胁全球公众健康的重要疾病之一。人类免疫缺陷病毒(HIV)侵入人体后首先攻击人体内的

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768835&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768856&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768855&type=

T淋巴细胞，肠道是淋巴组织最丰富的场所，因此，HIV会在肠道内聚集，破坏

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768857&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768859&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768841&type=

T淋巴细胞，致使患者肠道菌群失衡，引发一系列机会性感染和相关性疾病。HIV感染初期，

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768874&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768877&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768875&type=

T淋巴细胞在肠道内快速大量减少，

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768878&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768880&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768863&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768866&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768868&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768882&type=

T淋巴细胞比例下降，造成肠道黏膜免疫紊乱。HIV感染无症状期，慢性免疫激活是其独有特点。一些重要部位的

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768884&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768871&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768885&type=

T淋巴细胞数量稳定和肠道菌群的平衡可能是影响AIDS患者病情进展的重要因素。脾主运化有助于肠道菌群的恢复并助其发挥代谢吸收功能。中医药可有效调节AIDS患者的肠道菌群结构和机体的免疫重建状态。

Abstract

Acquired immunodeficiency syndrome (AIDS) is one of the major diseases that seriously threaten global public health due to its high infectivity and incurability. After entering the human body

HIV first attacks the

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768887&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768903&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768872&type=

T lymphocytes. Since the gut-associated lymphoid tissue (GALT) is the largest mass of lymphoid tissue in the body

HIV tends to accumulate in the intestinal tract and destroy

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768904&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768906&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768905&type=

T lymphocytes there

resulting in the dysbiosis of intestinal flora of the patient

leading to a series of opportunistic infections and related diseases. In the early stage of HIV infection

the number of

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768907&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768909&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768908&type=

T cells in the intestine decreases rapidly and massively

and the CD4/CD8 ratio decreases as well

causing immune disorders of the intestinal mucosa. The asymptomatic stage of HIV infection is characterized by chronic immune activation. The stable number of

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768910&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768912&type=

http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=28768892&type=

T lymphocytes in some important parts of the body and the balance of intestinal flora may be important factors affecting the progression of the disease. The spleen

which governs transportation and transformation

can play a crucial role in the recovery of the damaged intestinal flora and its function in host nutrient metabolism. By fortifying and activating the spleen

Traditional Chinese Medicine (TCM) can effectively regulate the intestinal flora and facilitate the immune reconstitution of AIDS patients.

关键词

艾滋病中医药肠道菌群肠道黏膜免疫功能

Keywords

AIDStraditional Chinese medicineintestinal floraintestinal mucosaimmune function

references

BRENCHLEY J M, DOUEK D C.HIV infection and the gastrointestinal immune system[J].Mucosal Immunology，2008, 1(1):23-30.

KLATT N R, FUNDERBUR N T, BRENCHLEY J M.Microbial translocation, immune activation, and HIV disease[J].Trends Microbiol，2013, 21(1):6-13.

杜珊，周月，陈斌.中医药与肠道微生态相关性研究进展[J].中国实验方剂学杂志，2019, 25(18):182-188.

RAVVA S V, STANKER L H.Real-time quantitative PCR detection of mycobacterium avium subsp paratuberculosis and differentiation from other mycobacteria using SYBR Green and TaqMan assays[J].Journal of Microbiological Methods，2005, 63(3):305-317.

PUSHPANATHAN P, MATHEW G S, SELVARAJAN S, et al.Gut microbiota and its mysteries[J].Indian J Med Microbiol，2019, 37(2):268-277.

PATEL R, DUPONT H L.New approaches for bacteriotherapy：prebiotics, new-generation probiotics, and synbiotics[J].Clin Infect Dis，2015, 60(Suppl 2):S108-S121.

YANG L, YIFENG L, XINJIE Y, et al.Physiological characteristics of lactobacillus casei strains and their alleviation effects against inflammatory bowel disease[J].J Microbiol Biotechnol，2021, 31(1):92-103.

陈越，陈兰玲.基于肠道微生态探讨中医药防治慢性肝病的作用机制[J].中医药临床杂志，2020, 32(4):646-650.

任慧妍，蒋建霞.肠道微生态与非消化系统疾病的研究进展[J].中国微生态学杂志，2018, 30(4):479-483,488.

汪席敏，李慧，杨光勇，等.肠道菌群及其相关疾病的研究现状[J].贵阳中医学院学报，2019, 41(4):73-76.

MCGINTY T, MIRMONSEF P, MALLON P W, et al.Does systemic inflammation and immune activation contribute to fracture risk in HIV？[J].Current Opinion in HIV and AIDS，2016, 11(3):253-260.

BJARNASON I, SHARPSTONE D R, FRANCIS N, et al. Intestinal inflammation, ileal structure and function in HIV[J].AIDS，1996, 10(12):1385-1391.

SHARPSTONE D R, NEILD P, CRANE R, et al. Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea[J].Gut，1999, 45(1):70-76.

EPPLE H J, ZEITZ M. HIV infection and the intestinal mucosal barrier[J].Annals of the New York Academy of Sciences，2012, 1258(1):19-24.

郭世奎.肠内营养对艾滋病患者肠屏障功能的影响及机制研究[D].昆明：昆明医科大学，2014.

BRENCHLEY J M, HILL B J, AMBROZAK D R, et al.T-cell subsets that harbor human immunodeficiency virus(HIV) in vivo: implications for HIV pathogenesis[J].J Virol，2004, 78(3):1160-1168.

QIONGSHENG L, LIJIE D, JACOB D E, et al. Peak SIV replication in resting memory CD4＋T cells depletes gut lamina propria CD4＋T cells[J].Nature，2005, 434(7037):1148-1152.

SANKARAN S, GUADALUPE M, REAY E, et al. Gut mucosal T cell responses and gene expression correlate with protection against in disease in long-term HIV-1-infected nonprogressors[J].Proc Natl Acad Sci USA，2005, 102(28):9860-9865.

KOTLER D P, GARTZ H P, LANGE M, et al.Enteropathy associated with the acquired immunodeficiency syndrom[J].Ann Intern Med，1984, 101(4):421-428.

VEAZEY R S, DEMARIA M A, Chalifoux L V, et al. Gastrointestinal tract as a major site of CD4＋T cell depletion and viral replication in SIV infection[J].Science，1998, 280(5362):427-431.

HAYNES B F.Gut microbes out of control in HIV infection[J].Nat Med，2006, 12(12):1351-1352.

KOVACS J A, LEMPICKI R A, SIDOROV I A, et al. Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV[J].J Exp Med，2001, 194(12):1731-1741.

BRENCHLEY J M, KARANDIKAR N J, BETTS M R, et al. Expression of CD57 defines replicative sesnscence and antigen-induced apoptotic death of CD8＋T cells[J].Blood，2003, 101(7):2711-2720.

HO D D, NEUMANN A U, PERELSON A S, et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection[J].Nature，1995, 373(6510):123-126.

GUOCHAO N，LEI L，LIBO Z，et al. Mesenchymal stem cell transplantation improves chronic colitis-associated complications through inhibiting the activity of toll-like receptor-4 in mice[J/OL].BMC Gastroenterol，2018，18(1)：127[2020-07-10].https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-018-0850-7https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-018-0850-7.

VEAZEY R, LACKNER A.The mucosal immune system and HIV-1 infection[J].Aids Rev，2003, 5(4):245-252.

BRENCHLEY J M, PRICE D A, DOUKE D C.HIV disease: fallout from a mucosal catastrophe？[J].Nat Immunol，2006, 7(3):235-239.

MARZIALI M, DE S W, CARELLO R, et al.T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART[J].AIDS，2006, 20(16):2033-2041.

HAIWEI Z, HONGXIN Z, YU H, et al. Excessive conversion and impaired thymic output contribute to disturbed regulatory T-cell homeostasis in AIDS patients with low CD4 cell counts[J].AIDS，2013, 27(7):1059-1069.

YIN M M, HAYES P J, GOTCH F M, et al. Elevated mucosal address in cell adhesion molecule-1 expression in acquired immunodeficiency syndrome is maintained during antiretroviral therapy by intestinal pathogens and coincides with increased duodenal CD4 T cell densities[J].J Infect Dis，2002, 185(8):1043-1050.

GUADALUPE M, SANKARAN S, GEORGE M D, et al. Viral suppression and immune restoration in the gastrointestinal mucosa of human immunodeficiency virus type 1-infected patients initiating therapy during primary or chronic infection[J].J Virol，2006, 80(16):8236-8247.

NOWAK P, MARIUS T, AVERSHINA E, et al. Gut microbiota diversity predicts immune status in HIV-1 infection[J].AIDS，2015, 29(18):2409-2418.

LOZUPONE C A, MARCELLA L, CAMPBELL T B, et al. Alterations in the gut microbiota associated with HIV-1 infection[J].Cell Host Microbe，2013, 14(3):29-39.

DILLON S M, LEE E J, KOTTER C V, et al. An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia[J].Mucosal Immunol，2014, 7(4):983-994.

MUDD J C, BRENCHLEY J M. Gut mucosal barrier dysfunction, microbial dysbiosis and their role in HIV-1 disease progression[J].J Infect Dis，2016, 214(2):58-66.

卢雯雯，余国友.中医“脾气虚证”与肠道微生态[J].国际中医中药杂志，2007, 29(6):96-99.

戴宇青.补益类中药对双歧杆菌生长的影响及其联合抗肿瘤作用研究[D].南京：南京中医药大学，2017.

吴秀，周联，罗霞，等.四君子汤多糖对脾虚小鼠肠道菌群及免疫功能的影响[J].中药药理与临床，2014, 30(2):12-14.

KOSIEWICZ M M，ZIRNHELD A L，ALARD P. Gut microbiota，immunity，and disease：a complex relationship[J/OL].Front Microbiology，2011，2：180[2020-07-10].https://www.frontiersin.org/articles/10.3389/fmicb.2011. 00180/fullhttps://www.frontiersin.org/articles/10.3389/fmicb.2011. 00180/full.

邱超，舒青龙.中医健脾与肠道微生态[J].中医药通报，2019, 18(6):25-28,32.

JUN X, HUBIAO C, SONGLIN L.Understanding the molecular mechanisms of the interplay between herbal medicines and gut microbiota[J].Med Res Rev，2017, 37(5):1140-1185.

胡晓丽，施中凯，吴晓岩，等.纳米化四君子汤对免疫抑制小鼠肠道菌群的影响[J].成都中医药大学学报，2010, 33(1):60-62.

李巧巧，王莉，胡永红.七才汤对小鼠肠道菌群影响的研究[J].湖北民族学院学报(医学版)，2011, 28(1):1-3.

何一伟.艾滋病患者肠道微生态初步研究[D].广州：广州医科大学，2014.

高国建，李鑫，董继鹏，等.基于高通量测序分析青蒿琥酯片对男性HIV/AIDS患者肠道细菌群落结构的影响[J].中国艾滋病性病，2021, 27(8):799-804.

许琪华，陈思言，李育萍，等.基于16S rDNA初探中药对免疫重建不良HIV/AIDS病人肠道菌群的影响[J].中国艾滋病性病，2020, 26(11):1150-1153,1177.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Advances in the effects of intestinal flora imbalance on ischemic stroke and in traditional Chinese medicine management

Influence of Fuzhengzhudu Pills on immune function in mice with immunological suppression

A Summary of Development of Treating AIDS with TCM

Discussion on essence of liver-spleen correlation based on gut-liver axis

Clinical study on intestinal flora characteristics of patients with advanced adenomatous colorectal polyps with different TCM syndromes

Related Author

Liang Wei

Meizhen Zhu

Shijie Sun

Rui Yu

Xianjing Zeng

LIU Bao-lu1

QUAN Fu-cai1

ZHAO Shu-ling1

Related Institution

Guangxi University of Chinese Medicine

2 Gansu College of Chinese Medicine

1 Tianshui Center of Disease Prevention and Control

广东深圳市福田区医院

⁰