Discussion on treating small airway obstruction caused by smoking from the perspective of injury to pulmonary vessels

Yanfen ZHAO; Qi WANG; Yunning JIANG; Jun TENG; Rui LI; Tianshu YANG; Yongsheng ZHANG

doi:10.3969/j.issn.2095-6606.2022.03.010

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Discussion on treating small airway obstruction caused by smoking from the perspective of injury to pulmonary vessels

更新时间：2022-06-02

- Discussion on treating small airway obstruction caused by smoking from the perspective of injury to pulmonary vessels
- Modern Chinese Clinical Medicine Vol. 29, Issue 3, Pages: 43-48(2022)
- 作者机构：
  
  1.北京中医药大学　北京　100029
  2.北京中医药大学东方医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.03.010
  CLC： R259
- Published：30 May 2022，
  
  Received：16 May 2021，
- 稿件说明：
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Yanfen ZHAO, Qi WANG, Yunning JIANG, et al. Discussion on treating small airway obstruction caused by smoking from the perspective of injury to pulmonary vessels. [J]. Modern Chinese Clinical Medicine 29(3):43-48(2022)
DOI：

Yanfen ZHAO, Qi WANG, Yunning JIANG, et al. Discussion on treating small airway obstruction caused by smoking from the perspective of injury to pulmonary vessels. [J]. Modern Chinese Clinical Medicine 29(3):43-48(2022) DOI： 10.3969/j.issn.2095-6606.2022.03.010.

摘要

小气道隶属于肺络系统中的气络部分，小气道结构功能的病变影响整个肺络系统以及肺生理功能的正常发挥。小气道阻塞是慢性阻塞性肺疾病的早期阶段，吸烟是其主要的危险因素之一。结合“毒”邪理论和络病学说，认为烟草烟雾是本病的使动因素，烟雾对小气道的影响包括介导气道炎症反应、黏液分泌和气道阻塞以及肺内组织损伤。烟毒伤络过程包括：留滞气络积蕴成毒阶段、成毒络损阶段和络损内生新毒阶段。治疗强调排毒通络、益气养阴，初期留滞气络积蕴成毒阶段宜清肺润络排毒，烟雾积聚成毒络损阶段宜益气通络排毒，络损内生新毒阶段宜逐瘀化痰通络。

Abstract

Small airways belong to the qi collateral of the lung collaterals

and their damages may result in abnormalities of the entire lung collateral system

and its physiological functions. Small airways obstruction is the early stage of chronic obstructive pulmonary disease (COPD)

for which smoking has been recognized as one of the main risk factors. Based on a combination of the theory of "toxic" pathogen and of pulmonary collateral diseases

this study proposes that tobacco smoke is the driving factor of this disease. The injury of lung collaterals by tobacco smoke is manifested in its effect on small airways

which mediates airway inflammation

mucus secretion and eventual obstruction of the passages. Tissue damage in the lungs are caused by smoke invading qi collaterals

which mainly involves the stages smoke evil accumulating in the qi collaterals until toxic levels

the smoke toxins inducing collateral damage

and new toxins result ing from the damaged collaterals. For the treatment

the focus should be placed on removing the toxins and unblocking the collaterals

tonifying qi and nourishing yin. At the initial stage

it is advisable to clear the lungs

moisten collaterals and expel the toxins. At the second stage

the key is to nourish qi and unblock the collaterals and remove the toxins. To deal with the new toxins generated in the third stage

it is suggested to remove stasis

dissolve phlegm and unblock the collaterals.

关键词

慢性阻塞性肺疾病小气道阻塞吸烟毒损肺络毒邪理论络病学说

Keywords

chronic obstructive pulmonary diseasesmall airway obstructionsmokingtoxic damage to lungsthe theory of "toxin"the theory of collateral disease

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