Evaluation of the clinical efficacy of <italic style="font-style: italic">Tiaogan Yangxue Jiawei</italic> Formula and acupressure ear beads for breast cancer related depression

Jianyi HUANG; Zhenzhen CHU; Tinghui WEN; Jinlong MA; Mengting ZHU; Jiang HUANG; Pei ZHANG; Suping MIAO

doi:10.3969/j.issn.2095-6606.2022.04.001

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Evaluation of the clinical efficacy of Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression

更新时间：2022-07-28

- Evaluation of the clinical efficacy of Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression
- Modern Chinese Clinical Medicine Vol. 29, Issue 4, Pages: 1-7(2022)
- 作者机构：
  
  1.北京中医药大学第一临床医学院　北京　100700
  2.北京同仁堂中医医院
  3.河北省张家口市万全区中医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.04.001
  CLC： R273
- Published：30 July 2022，
  
  Received：30 December 2021，
- 稿件说明：
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Jianyi HUANG, Zhenzhen CHU, Tinghui WEN, et al. Evaluation of the clinical efficacy of Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression. [J]. Modern Chinese Clinical Medicine 29(4):1-7(2022)
DOI：

Jianyi HUANG, Zhenzhen CHU, Tinghui WEN, et al. Evaluation of the clinical efficacy of Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression. [J]. Modern Chinese Clinical Medicine 29(4):1-7(2022) DOI： 10.3969/j.issn.2095-6606.2022.04.001.

摘要

目的

观察调肝养血方加味口服联合耳穴压丸治疗乳腺癌相关抑郁状态的临床疗效。

方法

将70例乳腺癌伴抑郁状态的患者随机分为治疗组35例、对照组35例，剔除脱落病例后治疗组32例、对照组31例。对照组采用乳腺癌常规标准化治疗，针对患者抑郁情绪进行心理疏导及健康宣教。治疗组在对照组的基础上加用调肝养血方加味口服配合耳穴压丸治疗。观察汉密尔顿抑郁量表(HAMD)评分、匹兹堡睡眠质量指数量表(PSQI)评分、中医证候积分、中医证候疗效、性激素水平，并进行安全性评价。

结果

HAMD评分治疗组治疗后较本组治疗前降低(

0.05)，对照组治疗后与本组治疗前比较，差异无统计学意义(

0.05)。治疗前2组比较差异无统计学意义(

0.05)，治疗后治疗组较对照组降低明显，2组治疗前后差值比较，差异有统计学意义(

0.05)，治疗组优于对照组。PSQI评分治疗组治疗后较本组治疗前降低(

0.05)，对照组治疗后与本组治疗前比较，差异无统计学意义(

0.05)。治疗前2组比较差异无统计学意义(

0.05)，治疗后治疗组较对照组降低明显，2组治疗前后差值比较，差异有统计学意义(

0.05)，治疗组优于对照组。中医证候积分治疗组治疗后较本组治疗前降低(

0.05)，对照组治疗后与本组治疗前比较，差异无统计学意义(

0.05)。治疗前2组比较差异无统计学意义(

0.05)，治疗后治疗组较对照组降低明显，2组治疗前后差值比较，差异有统计学意义(

0.05)，治疗组优于对照组。2组均无治愈病例，治疗组32例中，显效12例，有效18例，无效2例，总有效率为93.75%；对照组31例中，显效3例，有效15例，无效13例，总有效率为58.06%。经秩和检验，

＝－3.623，

0.05，说明治疗组疗效优于对照组。雌二醇(E

)、促卵泡生成素(FSH)及促黄体生成素(LH)水平2组治疗后与本组治疗前比较差异均无统计学意义(

0.05)。2组治疗前后差值比较，差异均无统计学意义(

0.05)。

结论

在西医常规治疗的基础上，调肝养血方加味口服联合耳穴压丸治疗乳腺癌相关抑郁状态具有较好的疗效。

Abstract

Objective

To evaluate the clinical efficacy of

Tiaogan Yangxue Jiawei

Formula and acupressure ear beads in patients with breast cancer related depression.

Methods

A total of 70 breast cancer patients with depression were randomly assigned to the control group and treatment group

with 35 cases in each group. After the drops-out and withdrawals excluded

there were 32 cases in the treatment group and 31 cases in the control group. The control group received conventional standardized treatment of breast cancer

and psychological counseling and health education for depression. On the basis of the control group

the treatment group received additional

Tiaogan Yangxue Jiawei

Formula and acupressure ear beads. Efficacy was assessed by using the Hamilton Depression Scale (HAMD)

Pittsburgh Sleep Scale (PSQI)

TCM syndrome score

sex hormone levels (estradiol

follicle stimulating hormone and luteinizing hormone) and safety indexes.

Results

The HAMD score in the treatment group was lower after treatment than before treatment (

0.05)

but there was no significant before-after difference in the control group (

0.05). Before treatment

there was no significant difference in HAMD score between the control group and treatment group (

0.05). After treatment

the HAMD score was significantly lower in the treatment group than in the control group. The before-after treatment difference between the two groups was statistically significant (

0.05)

greater in the treatment group than in the control group.The PSQI score in the treatment group was lower than that before treatment (

0.05)

but there was no significant before-after difference in the control group (

0.05). There was no significant difference between the control group and that before treatment (

0.05). After treatment

the PSQI score was significantly lower in the treatment group than in the control group. There was a significant difference between the two groups before and after treatment (

0.05)

greater in the treatment group than in the control group.The score of TCM syndrome in the treatment group was lower than that before treatment (

0.05)

but there was no significant before-after difference in the control group (

0.05). There was no significant difference between the two groups before treatment (

0.05). After treatment

the TCM syndrome score was significantly lower in the treatment group than in the control group. The difference between the two groups before and after treatment was statistically significant (

0.05)

greater in the treatment group than in the control group.There were no cured cases in the two groups. Among the 32 cases in the treatment group

12 cases were significantly effective

18 cases were effective and 2 cases were ineffective. The total effective rate was 93.75%; In the control group

3 cases were markedly effective

15 cases were effective and 13 cases were ineffective. The total effective rate was 58.06%. By rank sum test

= -3.623

(

0.05)

it indicated that the curative effect was better in the treatment group than in the control group.There was no significant difference in the levels of estradiol (E

)

follicle stimulating hormone (FSH) and luteinizing hormone (LH) between the two groups after treatment and before treatment (

0.05). There was no significant difference between the two groups before and after treatment (

0.05).

Conclusions

On the basis of modern medical routine treatment

the

Tiaogan Yangxue Jiawei

Formula and acupressure ear beads have a better curative effect in treating breast cancer related depression.

关键词

乳腺癌抑郁状态中医耳穴调肝养血方加味

Keywords

breast cancerdepressionChinese traditional medicineauricular acupointsTiaogan Yangxue Jiawei Formula

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Evaluation of the clinical efficacy of Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression

DOI：10.3969/j.issn.2095-6606.2022.04.001

摘要

Abstract

关键词

Keywords

references