Data mining-based medication rules of Chinese patent medicine for chronic bronchitis

Yu MING; Wenli ZHONG; Jieying ZHENG; Hongchun ZHANG; Xinyang SHU

doi:10.3969/j.issn.2095-6606.2022.04.005

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Data mining-based medication rules of Chinese patent medicine for chronic bronchitis

更新时间：2022-07-28

- Data mining-based medication rules of Chinese patent medicine for chronic bronchitis
- Modern Chinese Clinical Medicine Vol. 29, Issue 4, Pages: 27-31(2022)
- 作者机构：
  
  1.北京中医药大学　北京　100029
  2.中日友好医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.04.005
  CLC： R256.1
- Published：30 July 2022，
  
  Received：23 September 2021，
- 稿件说明：
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Yu MING, Wenli ZHONG, Jieying ZHENG, et al. Data mining-based medication rules of Chinese patent medicine for chronic bronchitis. [J]. Modern Chinese Clinical Medicine 29(4):27-31(2022)
DOI：

Yu MING, Wenli ZHONG, Jieying ZHENG, et al. Data mining-based medication rules of Chinese patent medicine for chronic bronchitis. [J]. Modern Chinese Clinical Medicine 29(4):27-31(2022) DOI： 10.3969/j.issn.2095-6606.2022.04.005.

摘要

目的

探索分析中成药治疗慢性支气管炎用药规律，为慢性支气管炎的治疗及新药研发提供参考。

方法

搜集《中华人民共和国药典》中治疗慢性支气管炎的中成药处方，运用中医传承辅助平台统计中药功能与主治、使用频次，通过关联规则方法分析中药的配伍规律、关联规则，运用熵聚类提取核心中药组合，挖掘候选新处方。

结果

《中华人民共和国药典》中治疗慢性支气管炎的中成药共有80种，14个品种有2种或2种以上剂型，共计102种，其中丸剂最多，共27种。治疗慢性支气管炎的中成药主要功效为止咳、化痰、平喘，同时还有清热、清肺、宣肺、润肺、降气等。80种中成药共使用中药167味，共计649次，使用频次≥7的中药共24味，出现频次较高的中药依次为甘草、苦杏仁、桔梗、麻黄、陈皮。使用频次≥10的中药组合共26组，出现频次较高的中药组合为甘草、苦杏仁，甘草、桔梗，陈皮、甘草，麻黄、苦杏仁。置信度≥0.7的中药关联规则共24组，置信度较高的中药关联规则为“桔梗，苦杏仁→甘草”“陈皮，桔梗→甘草”。基于复杂系统熵聚类，挖掘出8组核心中药组合。基于无监督熵层次聚类，挖掘出4首治疗慢性支气管炎的候选新处方。

结论

慢性支气管炎的常用治法为标本兼治，止咳、化痰、平喘以治标，调理脏腑、疏利气机以治本。中医治疗慢性支气管炎方法灵活多变，临床需根据实际情况辨证用药。

Abstract

Objective

To explore the medication rules of Chinese patent medicine for chronic bronchitis

in the hope of providing referrence for its clinical treatment and new drug development.

Methods

Chinese patent medicines for chronic bronchitis prescriptions were collected from

Chinese Pharmacopoeia

. The Traditional Chinese Medicine Inheritance Support System was used to count indications and frequency of traditional Chinese medicine. The rules of TCM compound and association were analyzed by using the method of association rules. Core medicinal combinations and candidate new prescriptions were extracted based on entropy clustering.

Results

Eighty kinds of Chinese patent medicines for chronic bronchitis treatment were found in

Chinese Pharmacopoeia

. Among them

14 kinds of Chinese patent medicines had more than 2 dosage forms

totaling 102 kinds

and the dosage form was mainly pills which are 27 kinds. The main functions of Chinese patent medicines of chronic bronchitis are relieving cough

transforming phlgem

relieving panting

and also clearing heat

clearing the lung

dispersing the lung

moistening the lung and downbearing qi.A total of 80 kinds of Chinese patent medicines for the treatment of chronic bronchitis were included

involving 167 medicinals

and the frequency of medicinals reached 882 times

24 medicinals with its frequency ≥ 7. Most frequently used medicinals were

Gancao

(Radix et Rhizoma Glycyrrhizae)

Kuxingren

(Semen Armeniacae Amarum)

Jiegeng

(Radix Platycodonis)

Mahuang

(Herba Ephedrae) and

Chenpi

(Pericarpium Citri Reticulatae). There were 26 medicinal combinations

with its frequency≥10

for instance

Gancao

and

Kuxingren

Gancao

and

Jiegeng

Chenpi

and

Gancao

Mahuang

and

Kuxingren

. Twenty-four medicinals combinations were revealed

with its frequency≥10

for instance

Jiegeng

Kuxingren

→

Gancao

" "

Chenpi

Jiegeng

→

Gancao

" . Based on complex system entropy clustering

a group of 8 core drug combinations were obtained. Based on unsupervised entropy hierarchical clustering

4 new prescriptions for treatment of chronic bronchitis were obtained.

Conclusions

The common treatment for chronic bronchitis is to treat both the symptoms and the root causes. Treating the symptoms include relieving cough

transforming phlegm and relieving panting while treating the root causes include coordinating viscera and bowels and regulating Qi. The TCM treatment of chronic bronchitis is flexible

based on clinical syndrome differentiation.

关键词

慢性支气管炎用药规律数据挖掘中成药

Keywords

chronic bronchitismedication ruledata miningChinese patent medicine

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