On amyotrophic lateral sclerosis from the perspective of insidious toxin theory

YANG Qingbo; HE Pengfei; MA Bin; FENG Guangshu; HUANG Xianghong; WU Huihong

doi:10.3969/j.issn.2095-6606.2022.05.013

您当前的位置：

首页 >

文章列表页 >

On amyotrophic lateral sclerosis from the perspective of insidious toxin theory

更新时间：2022-10-17

- On amyotrophic lateral sclerosis from the perspective of insidious toxin theory
- Modern Chinese Clinical Medicine Vol. 29, Issue 5, Pages: 55-59(2022)
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100700
  2.北京中医药大学东直门医院脑病科
  3.聊城市中医医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.05.013
  CLC： R259
- Published：30 September 2022，
  
  Received：07 April 2022，
- 稿件说明：
移动端阅览
YANG Qingbo, HE Pengfei, MA Bin, et al. On amyotrophic lateral sclerosis from the perspective of insidious toxin theory. [J]. Modern Chinese Clinical Medicine 29(5):55-59(2022)
DOI：

YANG Qingbo, HE Pengfei, MA Bin, et al. On amyotrophic lateral sclerosis from the perspective of insidious toxin theory. [J]. Modern Chinese Clinical Medicine 29(5):55-59(2022) DOI： 10.3969/j.issn.2095-6606.2022.05.013.

摘要

肌萎缩侧索硬化(ALS)是一种致命性的神经系统变性疾病，其病因及发病机制尚不明晰。伏毒是指潜伏于体内、不被察觉、待发作时才显现出来的毒邪，致病表现为毒性猛、病情重或反复迁延难祛。从伏毒角度探讨ALS，ALS隐匿性起病、病情进展迅速、病变受累区域广泛、临床症状典型等特点与伏毒隐伏、暗耗、暴戾、杂合、多变特点类似，提出先天、外感和内生之伏毒为ALS的病因，阐述伏毒蛰伏于肝脾肾，损伤脑髓，脑络闭阻，并以督脉和络脉为主要传递渠道的病机，以益精填髓、解毒通络为基本治则治法，为ALS中医诊治提供一定的思路。

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal degenerative disease of the nervous system

the etiology and pathogenesis of which remain unclear. Insidious toxins refer to the toxin and evil in the human body

which are often unnoticed and emerge only with the onset of the disease. Its clinical characteristics are strong toxicity

severe illness

or repeated relapse. This paper discusses ALS from the perspective of insidious toxins. It is considered that the characteristics of ALS

such as occult onset

rapid progress

extensive areas of the body affected and typical clinical symptoms

are similar to those of insidious toxins

which include latency

stealthy undermining of the body

ferocious onset and progression

complexity

and variability. It is proposed that congenital

exogenous and endogenous insidious toxins are the cause of ALS. The insidious toxins lurk in the liver

spleen and kidney

damage the brain marrow

block brain collaterals

and take the governor vessels and collateral vessels as the main transmission channels. In treatment

it is proposed as the basic principle to boost essence and fill the marrow

resolve toxins and dredge collaterals. A new perspective for TCM diagnosis and treatment of ALS is provided in this study.

关键词

肌萎缩侧索硬化伏毒脑髓治法

Keywords

amyotrophic lateral sclerosisinsidious toxinbrain marrowtreatment methods

references

贾建平，陈生弟.神经病学[M].8版.北京：人民卫生出版社，2018: 262.

裘昌林.肌萎缩侧索硬化病名病机治疗思路探讨[J].浙江中西医结合杂志，2014, 24(3): 187-190.

汪双双，杨晓军，邓铁涛，等.邓铁涛教授治疗肌萎缩侧索硬化症经验整理[J].广州中医药大学学报，2010, 27(3): 310-312.

冯广树，马斌，冯广娟，等.浅论“毒”邪为肌萎缩侧索硬化症发病的重要病因及其辨治思路[J].环球中医药，2020, 13(2): 278-281.

黄向鸿，贺鹏飞，马斌，等.探讨开玄法在肌萎缩侧索硬化症治疗中的应用[J].环球中医药，2021, 14(12): 2205-2208.

王叔和.脉经[M].郭君双，整理.北京：人民卫生出版社，2017: 158-159.

王燕昌.《王氏医存》校注[M].程传浩，吴新科，校注.郑州：河南科学技术出版社，2014: 97.

周仲瑛.“伏毒”新识[J].世界中医药，2007, (2)2: 73-75.

AL-CHALABI A，VANDENBERG L H，VELDINK J. Gene discovery in amyotrophic lateral sclerosis：implications for clinical management[J].Nat Rev Neurol，2017, 13(2): 96-104.

GHASEMI M，BROWN R H. Genetics of amyotrophic lateral sclerosis[J/OL].Cold Spring Harb Perspect Med,2018,8(5):a024125[2022-04-01].https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932579https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932579.

万全.幼科发挥[M].何永，整理.北京：人民卫生出版社，2006: 13.

GUNNARSSON L G，BODIN L.Amyotrophic lateral sclerosis and occupationalexposures：a systematic literature review and meta-analyses[J/OL].lnt J Environ Res Public Health,2018,15(11):2371[2022-04-01].https://www.mdpi.com/1660-4601/15/11/2371/htmhttps://www.mdpi.com/1660-4601/15/11/2371/htm.

李岩，孙景波，华荣.国医大师张学文教授毒瘀交夹论治中风病学术思想浅析[J].中华中医药杂志，2016, 31(3): 872-874.

D’AMICO E，GROSSO G，NIEVES J W，et al.Metabolic abnormalities, dietary risk factors and nutritional management in amyotrophic lateral sclerosis[J/OL].Nutrients,2021,13(7):2273[2022-04-01].https://www.mdpi.com/2072-6643/13/7/2273/htmhttps://www.mdpi.com/2072-6643/13/7/2273/htm.

蔡正一，崔丽英.肌萎缩侧索硬化症状前期研究的现状与启示[J].中华医学杂志，2021, 101(7): 520-523.

李晓光，刘明生，崔丽英.肌萎缩侧索硬化的临床分型、分期及病情评估[J].协和医学杂志，2018, 9(1): 69-74.

张肖.肌萎缩侧索硬化症症状与红外热像图的相关研究[D].北京：北京中医药大学，2016.

尚晓玲，高颖.关于多发性硬化病因病机的理论探讨[J].中国中医基础医学杂志，2006, 12(6): 414-415.

张介宾.类经[M].郭洪耀，校注.北京：中国中医药出版社，1997: 103.

王岩，白艳杰，张铭，等.艾灸督脉对肾精亏虚型卒中后轻度认知障碍患者认知功能和中医症状的临床疗效研究[J].中国全科医学，2022, 25(12): 1487-1492.

张介宾.景岳全书[M].夏之秋，校注.北京：中国中医药出版社，1996: 307.

张锡纯.医学衷中参西录[M].鲁瑛，梁宝祥，高慧，等，校注.太原：山西科学技术出版社，2009.

王建伟，张允岭，贺立娟，等.从气－血－脑神关系谈中风病病机演变[J].新中医，2018, 50(7): 225-227.

孙思邈.备急千金要方[M].太原：山西科学技术出版社，2010: 352.

叶天士，何澹庵.未刻本叶氏医案/何澹庵医案[M].程门雪，校.上海：上海科学技术出版社，2010: 79.

董春霄，张晓峰，肖新春，等.张晓峰应用祛瘀化湿解毒通络法治疗子宫腺肌症经验[J].河北中医，2020, 42(2): 174-177.

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Construction of therapeutic theory of acupuncture-moxibustion:taking treatment of impediment with acupuncture as example

Related Author

ZHAO Jing-sheng

Related Institution

Institute of Acupuncture and Moxibustion,Key Unit of Theory and Methodology of Acupuncture and Moxibustion of State Administration of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences

⁰