Effect of acupuncture at Shenmen (HT 7) on amplitude of low frequency fluctuation after sleep deprivation based on cortical analysis

YAO Hao; ZHENG Ruwen; ZHENG Sisi; FENG Zhengtian; FENG Sitong; LIU Xinzi; CAI Yongli; NING Yanzhe

doi:10.3969/j.issn.2095-6606.2022.06.001

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Effect of acupuncture at Shenmen (HT 7) on amplitude of low frequency fluctuation after sleep deprivation based on cortical analysis

更新时间：2022-12-03

- Effect of acupuncture at Shenmen (HT 7) on amplitude of low frequency fluctuation after sleep deprivation based on cortical analysis
- Modern Chinese Clinical Medicine Vol. 29, Issue 6, Pages: 1-5(2022)
- 作者机构：
  
  1.北京中医药大学东方医院针灸科　北京　100078
  2.首都医科大学附属北京安定医院，国家精神医学中心，国家精神心理疾病临床研究中心，精神疾病诊断与治疗北京市重点实验室
  3.人脑保护高精尖创新中心，首都医科大学
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.06.001
  CLC： R2-03
- Published：30 November 2022，
  
  Received：12 January 2022，
- 稿件说明：
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YAO Hao, ZHENG Ruwen, ZHENG Sisi, et al. Effect of acupuncture at Shenmen (HT 7) on amplitude of low frequency fluctuation after sleep deprivation based on cortical analysis. [J]. Modern Chinese Clinical Medicine 29(6):1-5(2022)
DOI：

YAO Hao, ZHENG Ruwen, ZHENG Sisi, et al. Effect of acupuncture at Shenmen (HT 7) on amplitude of low frequency fluctuation after sleep deprivation based on cortical analysis. [J]. Modern Chinese Clinical Medicine 29(6):1-5(2022) DOI： 10.3969/j.issn.2095-6606.2022.06.001.

摘要

目的

基于皮层分析针刺神门穴对24 h睡眠剥夺后大脑相关脑区低频振荡振幅(amplitude of low frequency fluctuation

ALFF)活动的影响。

方法

30名健康受试者经过24 h睡眠剥夺后，针刺双侧神门穴，在睡眠剥夺前、后和针刺神门穴后各进行1次功能磁共振扫描。同时基于皮层采用DPABISurf软件进行预处理并计算睡眠剥夺前、后和针刺后全脑的ALFF值。

结果

与睡眠剥夺前比，睡眠剥夺后ALFF值升高的脑区主要包括双侧中央后回、双侧中央前回、右侧中央旁小叶；ALFF值降低的脑区主要包括双侧角回、双侧后扣带回、右侧额下回。与睡眠剥夺后相比，针刺神门穴后ALFF值升高的脑区包括右侧眶额上回和额下回；ALFF值降低的脑区包括双侧中央后回、左侧中央前回、双侧中央旁小叶和左侧脑岛。针刺后与睡眠剥夺前相比，未发现ALFF值明显异常的脑区。

结论

针刺神门穴对睡眠剥夺后多个与认知功能和情绪调节相关脑区的功能活动异常起调节作用，这可能是针刺干预睡眠剥夺的效应机制。

Abstract

Objective

To explore the effect of acupuncture at Shenmen(HT 7)on the activity of amplitude of low frequency fluctuation (ALFF) after 24 h sleep deprivation based on cortical analysis.

Methods

A total of 30 healthy subjects were recruited

and received the needling at bilateral Shenmen acupoints (HT 7) after 24 h sleep deprivation. The functional magnetic resonance scanning (fMRI) was performed before and after sleep deprivation

and after acupuncture at HT 7. Meanwhile

DPABISurf was used to preprocess and calculate the ALFF values.

Results

Compared with that before sleep deprivation

the brain regions with increased ALFF values after sleep deprivation mainly included bilateral posterior central gyrus

bilateral anterior central gyrus and right paracentral lobule

meanwhile the brain regions with decreased ALFF values mainly include bilateral angular gyrus

bilateral posterior cingulate gyrus and right inferior frontal gyrus. Compared with that after sleep deprivation

the brain regions with increased ALFF values after needling at HT 7 mainly included the right superior orbitofrontal gyrus and inferior frontal gyrus

and the brain regions with decreased ALFF values included the bilateral posterior central gyrus

left anterior central gyrus

bilateral paracentral lobules

and left insula. Compared with that before sleep deprivation

there was no significant change in ALFF value in brain regions after acupuncture.Conclusions Acupuncture at HT 7 can modulate the abnormal functional activities of multiple brain regions related to cognitive functions and emotional regulation after sleep deprivation

which may be the effect mechanism of acupuncture on sleep deprivation.

关键词

睡眠剥夺针刺神门穴功能磁共振低频振荡振幅

Keywords

sleep deprivationacupunctureShenmen (HT 7)fMRIamplitude of low frequency fluctuation

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