Clinical research of treating ovulation disorders in polycystic ovary syndrome with endocrine-regulating acupuncture

ZHANG Xiaoxue; GUO Xinfeng; WANG Hanlin; XIE Changcai

doi:10.3969/j.issn.2095-6606.2022.06.003

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Clinical research of treating ovulation disorders in polycystic ovary syndrome with endocrine-regulating acupuncture

更新时间：2022-12-03

- Clinical research of treating ovulation disorders in polycystic ovary syndrome with endocrine-regulating acupuncture
- Modern Chinese Clinical Medicine Vol. 29, Issue 6, Pages: 11-16(2022)
- 作者机构：
  
  1.广州中医药大学第二临床医学院　广州　510405
  2.广东省中医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.06.003
  CLC： R246.3
- Published：30 November 2022，
  
  Received：10 April 2022，
- 稿件说明：
移动端阅览
ZHANG Xiaoxue, GUO Xinfeng, WANG Hanlin, et al. Clinical research of treating ovulation disorders in polycystic ovary syndrome with endocrine-regulating acupuncture. [J]. Modern Chinese Clinical Medicine 29(6):11-16(2022)
DOI：

ZHANG Xiaoxue, GUO Xinfeng, WANG Hanlin, et al. Clinical research of treating ovulation disorders in polycystic ovary syndrome with endocrine-regulating acupuncture. [J]. Modern Chinese Clinical Medicine 29(6):11-16(2022) DOI： 10.3969/j.issn.2095-6606.2022.06.003.

摘要

目的

观察调泌针法治疗多囊卵巢综合征排卵障碍的疗效和安全性。

方法

自2020年6月—2021年2月，收集在广东省中医院针灸及妇科门诊就诊并符合纳入排除标准的患者65例，采用简单随机化方法，按照先后顺序随机分为对照组(克罗米芬组33例)和治疗组(调泌针法组32例)。2组均在生活方式指导的基础上进行，对照组予口服枸橼酸氯米芬片，从月经第2～5日开始服用，50 mg/d，共5 d；治疗组予调泌针法针刺，隔日1次，每周3次，2组各治疗3个月经周期，观察2组的性激素水平、中医症状评分的变化，排卵及妊娠情况并对比其差异。

结果

①排卵率：治疗组排卵率为60.87%；对照组为63.24%；经统计学分析差异没有统计学意义(

0.05)。②性激素水平：治疗后2组卵泡刺激素(Follicle-stimulating hormone，FSH)较治疗前明显增高，黄体生成素(Luteinizing hormone，LH)、LH/FSH、睾酮(Testosterone，T)较治疗前均有明显降低，差异具有统计学意义(

0.05)。治疗组LH、LH/FSH、T降低幅度更大，差异有统计学意义(

0.05)；2组在FSH增高方面无明显差异(

0.05)。③妊娠率：治疗组妊娠率42.86%；对照组妊娠率41.94%，经比较，2组无明显差异(

0.05)。

结论

调泌针法可改善多囊卵巢综合征排卵障碍，有助于促进排卵和生育，改善性激素水平。

Abstract

Objective

To observe the efficacy and safety of endocrine-regulating acupuncture in the treatment of ovulation disorders in polycystic ovary syndrome.

Methods

From June 2020 to February 2021

65 patients were recruited who met the inclusion criteria in the Acupuncture Clinics and Gynecological Clinics of Guangdong Provincial Hospital of Chinese Medicine. The simple randomization method was used and they were randomly divided into two groups according to the order of their inclusion

namely the control group (clomiphene group

33 cases) and the treatment group (endocrine-regulating acupuncture group

32 cases). Both groups were given lifestyle guidance. The control group was given clomiphene citrate tablets

starting from the 2nd to 5th day of menstruation

50 mg/d

for 5 days; the treatment group was given endocrine-regulating acupuncture

once every other day

three times a week. The two groups were treated for 3 menstrual cycles

and the changes in sex hormone levels

TCM symptom scores

ovulation and pregnancy were observed and the differences were identified.

Results

① Ovulation rate: The ovulation rate of the treatment group was 60.87%; the control group was 63.24%; the difference was not significant after statistical analysis (

0.05). ② Sex hormone level: after treatment

follicle-stimulating hormone (FSH) in the two groups was significantly higher than before treatment; luteinizing hormone (LH)

LH/FSH

testosterone (T) were significantly lower than before treatment

with statistical significance (

0.05).The reduction of LH

LH/FSH and T in the treatment group was greater

and the difference was significant (

0.05); in terms of FSH increase

the difference between the two groups was not statistically significant (

0.05). ③ Pregnancy rate: The pregnancy rate of the treatment group was 42.86%; the pregnancy rate of the control group was 41.94%. After comparison

there was no significant difference between the two groups (

0.05).

Conclusion

Endocrine-regulating acupuncture can improve ovulation disorders in polycystic ovary syndrome

help promote ovulation and fertility

and improve sex hormone levels.

关键词

调泌针法多囊卵巢综合征排卵障碍

Keywords

endocrine-regulating acupuncturepolycystic ovary syndromeovulation disorders

references

王永慧.中国妇女孕前肥胖合并多囊卵巢综合征诊治路径[J].中国妇幼健康研究，2018,29(11):1361-1371.

贾汝楠，刘玉兰.多囊卵巢综合征中西医研究进展[J].世界中医药，2020,15(12):1827-1831.

中华医学会妇产科学分会内分泌学组及指南专家组.多囊卵巢综合征中国诊疗指南[J].中华妇产科杂志，2018,53(1):2-6.

陈嘉欣，郁洁，王翰林，等.调泌针法理论特色及其临床应用[J].新中医，2018,50(5):232-234.

谢长才.肥胖内分泌疾病针灸治疗[M].北京：人民卫生出版社，2016.

罗世芳.排卵障碍性不孕症诊断及治疗[M].北京：中国医药科技出版社，2012:14.

李嘉萍.针刺配合神阙穴隔盐灸法治疗多囊卵巢综合征的临床研究[D].广州：广州中医药大学，2018.

多囊卵巢综合征相关不孕治疗及生育保护共识[J].生殖医学杂志，2020,29(7):843-851.

谈勇，黄紫微.排卵障碍性不孕症的中西医结合诊治思考[J].中国中西医结合杂志，2019,39(5):521-524.

孙春艳，陈淼鑫.多囊卵巢综合征不孕症患者的促排卵治疗[J].世界临床药物，2020,41(8):575-580.

李继俊.妇产科内分泌治疗学[M].4版.北京：科学出版社，2018:386-387.

寇丽辉，侯丽辉，王颖.非药物治疗多囊卵巢综合征的研究进展[J].现代中西医结合杂志，2018,27(2):226-228.

汪乔，邓海平，程珂，等.针灸为主治疗多囊卵巢综合征致不孕症的临床及实验研究近况[J].上海中医药大学学报，2019,33(5):88-92.

尹萍，李丽，路璐，等.针刺联合辅助生殖技术对多囊卵巢综合征患者临床妊娠结局影响的Meta分析及GRADE质量评价[J].中华中医药杂志，2020,35(2):854-858.

郑淑珍.通元针法对CC周期排卵障碍性不孕治疗效应的临床研究[D].广州：广州中医药大学，2019.

任晓暄，朱兵，高昕妍，等.针刺不同穴位对雌性大鼠下丘脑GnRH相关神经元活动的影响[J].北京中医药大学学报，2010,33(3):191-195.

翟伟平.益气排卵法针刺结合克罗米芬治疗多囊卵巢综合征排卵障碍的临床研究[D].西宁：广西中医药大学，2016.

王少军，谭连红，张娇娇，等.垂体、脊髓在电针刺调节下丘脑－垂体－肾上腺皮质轴功能的作用[J].中国中医基础医学杂志，2013,19(5):537-539.

JOHANSSON J，REDMAN L，VELDHUIS P P，et al.Acupuncture for ovulation induction in polycystic ovary syndrome：a randomized controlled trial[J].Am J Physiol Endocrinol Metab，2013,304(9):E934-E943.

MA H L，XIE L Z，GAO J S，et al.Acupuncture and clomiphene for Chinese women with polycystic ovary syndrome (PCOSAct)：statistical analysis approach with the revision and explanation[J].Trials，2018,19(1):601.

CHEN H，LIM C.The efficacy of using acupuncture in managing polycystic ovarian syndrome[J].Curr Opin Obstet Gynecol，2019,31(6):428-432.

王宝莲.针灸周期疗法治疗肾虚血瘀型PCOS排卵障碍的临床观察[D].福州：福建中医药大学，2020.

PENG Y, YANG X, LUO X, et al.Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress[J].Biol Res，2020,53(1):50.

何晓燕，涂春艳.针灸治疗不孕症的机理研究进展[J].世界中西医结合杂志，2017,12(7):1033-1036.

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