TCM and Western medicine understandings of pathogenesis of acute pancreatitis based on "obstruction causes pain"

LIN Juan; HAN Chenxia; JIANG Kun; HUANG Wei; JIN Tao; XIA Qing

doi:10.3969/j.issn.2095-6606.2022.06.005

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TCM and Western medicine understandings of pathogenesis of acute pancreatitis based on "obstruction causes pain"

更新时间：2022-12-03

- TCM and Western medicine understandings of pathogenesis of acute pancreatitis based on "obstruction causes pain"
- Modern Chinese Clinical Medicine Vol. 29, Issue 6, Pages: 20-25(2022)
- 作者机构：
  
  四川大学华西医院　成都　610000
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2022.06.005
  CLC： R256.33
- Published：30 November 2022，
  
  Received：01 April 2022，
- 稿件说明：
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LIN Juan, HAN Chenxia, JIANG Kun, et al. TCM and Western medicine understandings of pathogenesis of acute pancreatitis based on "obstruction causes pain". [J]. Modern Chinese Clinical Medicine 29(6):20-25(2022)
DOI：

LIN Juan, HAN Chenxia, JIANG Kun, et al. TCM and Western medicine understandings of pathogenesis of acute pancreatitis based on "obstruction causes pain". [J]. Modern Chinese Clinical Medicine 29(6):20-25(2022) DOI： 10.3969/j.issn.2095-6606.2022.06.005.

摘要

剧烈上腹部疼痛作为急性胰腺炎(acute pancreatitis

AP)的诊断标准之一，与患者的临床结局指标和主观体验密切相关。越来越多的临床和基础研究证实，疼痛作为AP损伤早期事件，可能参与疾病发展。传递疼痛的外周神经在局部促进炎症因子的合成与释放，进而通过介导神经源性炎症加重胰腺损伤，与中医“不通则痛，痛则不通”以及AP “邪郁-热盛-气闭”的病机演变规律不谋而合，从疼痛角度阐述神经系统参与AP发生发展的相关机制、梳理中医病机理论内涵，并总结临床相关治疗证据加以佐证。

Abstract

Severe upper abdominal pain

as one of the diagnosis criterions of acute pancreatitis (AP)

is closely related to the clinical outcomes and subjective feelings of patients. Elevated evidence of clinical and basic studies indicated that pain

as an early event

may relate to the development and severity of AP. Pancreatic nerve transmits sensory information and enhances the synthesis and release of local inflammatory cytokines

a process called neurogenic inflammation

which may aggravate the damage to the pancreas. This process is coincided with the pathogenesis of "pathogen constraint-excessive heat-qi block" in AP and the "obstruction causes pain" theory in TCM. The authors illustrated the role of neural mechanism in AP

also the TCM pathogenesis of the disease and related clinical evidence.

关键词

急性胰腺炎不通则痛中西医病机

Keywords

acute pancreatitisobstruction causes painintegrated traditional Chinese and western medicinepathogenesis

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