Discussion on treating coronary microcirculation dysfunction from the perspective of qi transformation

LIU Yong; WU Yang; KANG Jingfan; ZHUANG Rui; ZHANG Lijing

doi:10.3969/j.issn.2095-6606.2023.01.014

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Discussion on treating coronary microcirculation dysfunction from the perspective of qi transformation

更新时间：2023-02-02

- Discussion on treating coronary microcirculation dysfunction from the perspective of qi transformation
- Modern Chinese Clinical Medicine Vol. 30, Issue 1, Pages: 61-64(2023)
- 作者机构：
  
  1.北京中医药大学东方医院　北京　100078
  2.北京中医药大学东直门医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.01.014
  CLC： R259
- Published：30 January 2023，
  
  Received：15 December 2021，
- 稿件说明：
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LIU Yong, WU Yang, KANG Jingfan, et al. Discussion on treating coronary microcirculation dysfunction from the perspective of qi transformation. [J]. Modern Chinese Clinical Medicine 30(1):61-64(2023)
DOI：

LIU Yong, WU Yang, KANG Jingfan, et al. Discussion on treating coronary microcirculation dysfunction from the perspective of qi transformation. [J]. Modern Chinese Clinical Medicine 30(1):61-64(2023) DOI： 10.3969/j.issn.2095-6606.2023.01.014.

摘要

冠状动脉微循环障碍(CMD)已成为冠心病防治的研究热点，中医将其归属于“胸痹”“心痛”的范畴，认为其病机多归于心络瘀阻，治疗从活血化瘀着手。气化是人体新陈代谢的基本形式，广义的气化是指自然界天地阴阳之气交感所产生的一切变化及其产生的现象，狭义的气化是指人体生命活动过程中生化、代谢活动及其产生的生理病理现象。气化与微血管内皮细胞功能、冠脉微循环供血、冠脉微循环血液流变学以及冠脉微循环炎症反应之间有密切关系，气化失常可引起血液流变学改变、炎症反应、内皮细胞功能障碍等，进而导致CMD。心血瘀阻证(阳化太过)、寒凝气滞证(阳化不及)、痰瘀互结证(阴化太过)、气虚血瘀证(阴化不及)4个证候与气化失调关系最为密切。本文将从临床表现、治则治法及用药等方面展开论述，为临床防治CMD功能紊乱提供新的思路。

Abstract

Coronary microvascular dysfunction (CMD) has become a focus of research in the prevention and treatment of coronary heart disease. Traditional Chinese medicine classifies it as "chest impediment" or "heart pain"

and believes that the pathogenesis of CMD is mostly attributed to heart collateral stasis. The treatment starts from invigorating blood and removing stasis. Qi transformation is the basic form of human metabolism. In broad terms

it refers to all changes and phenomena generated by the interaction of yin and yang in nature. In the narrow sense

it refers to fundamental metabolic processes and biochemical activities and their pathophysiological phenomenon generated during human life activities. Qi transformation is closely related to microvascular endothelial cell function

coronary microcirculatory perfusion

coronary microcirculation hemorheology

and coronary microcirculation inflammatory reaction. Abnormalities in qi transformation can cause changes in hemorheology

inflammatory reaction

endothelial cell dysfunction

etc.

and then lead to CMD. The four patterns of heart blood stasis obstruction (excessive transformation of yang)

qi stagnation due to congealing cold (insufficient transformation of yang)

binding of phlegm and stasis (excessive transformation of yin)

and qi deficiency and blood stasis (insufficient transformation of yin) are most closely related to imbalanced qi transformation

which are discussed from the aspects of clinical manifestations

principles of treatment and medication

with the aim to provide new ideas for clinical prevention and treatment of CMD.

关键词

气化冠状动脉微循环障碍理论探讨

Keywords

qi transformationcoronary microvascular dysfunctiontheoretical discussion

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