Discussion on the treatment of Alzheimer disease from the theory of "the kidney stores the will"

ZHENG Maofeng; SHI Jing; NI Jingnian; WEI Mingqing; TIAN Jinzhou

doi:10.3969/j.issn.2095-6606.2023.01.015

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Discussion on the treatment of Alzheimer disease from the theory of "the kidney stores the will"

更新时间：2023-02-02

- Discussion on the treatment of Alzheimer disease from the theory of "the kidney stores the will"
- Modern Chinese Clinical Medicine Vol. 30, Issue 1, Pages: 65-68(2023)
- 作者机构：
  
  北京中医药大学东直门医院　北京　100700
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.01.015
  CLC： R259
- Published：30 January 2023，
  
  Received：30 March 2022，
- 稿件说明：
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ZHENG Maofeng, SHI Jing, NI Jingnian, et al. Discussion on the treatment of Alzheimer disease from the theory of "the kidney stores the will". [J]. Modern Chinese Clinical Medicine 30(1):65-68(2023)
DOI：

ZHENG Maofeng, SHI Jing, NI Jingnian, et al. Discussion on the treatment of Alzheimer disease from the theory of "the kidney stores the will". [J]. Modern Chinese Clinical Medicine 30(1):65-68(2023) DOI： 10.3969/j.issn.2095-6606.2023.01.015.

摘要

阿尔茨海默病(AD)是一种以进行性认知损害为特征的神经变性病，也是最常见的痴呆类型。AD进展期间有多个证候演变并具有一定规律性，基于《黄帝内经》“肾藏志”理论，提出肾虚证候级联假说。从“肾藏志”理论探讨AD的治疗思路，“肾藏志”功能正常，则人的记忆和神志活动保持正常。“肾藏志”异常不仅是AD的启动因子，也是贯穿AD全过程的核心病机。“肾藏志”与记忆和人体的精神活动均有密切联系。补肾生精强志是AD的基本治法，早期以补肾为主，中期以活血、化痰、泻火为主，晚期以解毒固脱为主，为序贯疗法中“早期补肾为主并贯穿全程”提供了理论依据。

Abstract

Alzheimer’s disease (AD)

a neurodegenerative disease characterized by progressive cognitive impairment

is the most common type of dementia. During the progression of AD

multiple TCM patterns may be present

which follow certain rules. Based on the theory of "the kidney stores the will" proposed in

The Yellow Emperor’s Inner Classic

hypothesis of kidney deficiency in AD and its sequential therapy based on kidney-reinforcing was proposed in this study. The therapeutic idea of AD is discussed from the theory of "the kidney stores the will" . If this function is normal

the memory and mental activity remain normal. Abnormalities in the will-storing function of the kidney are not only the initiator of AD

but also the core pathogenesis throughout the whole process of the disease. In light of the close connection between "the kidney stores the will" and the memory and the spiritual activities of human body

the method of supplementing the kidney

producing essence and strengthening the will is proposed as the basic treatment of AD. The focus should be placed on supplementing the kidney in the early stage

invigorating blood

resolving phlegm and draining fire in the middle

and resolving toxins and stopping collapse in the late stage

which provides a theoretical basis for "supplementing the kidney in the early stage and throughout the treatment" in the sequential therapy.

关键词

阿尔茨海默病肾虚级联假说肾藏志

Keywords

Alzheimer diseasecascade hypothesis of kidney deficiencythe kidney stores the will

references

GRAEBER M B，KOSEL S，EGENSPERGER R，et al.Rediscovery of the case described by alois alzheimer in 1911：historical，histological and molecular genetic analysis[J].Neurogenetics，1997，1(1): 73-80.

ALZHEIMER’S ASSOCIATION. 2019 Alzheimer’s disease facts & figures[J].Alzheimers Dement，2019，15(3): 321-387.

GBD 2016 DEMENTIA COLLABORATORS. Global，regional，and national burden of alzheimer’s disease and other dementias，1990–2016：a systematic analysis for the global burden of disease study 2016[J].Lancet Neurol，2019，18(1): 88-106.

WATTMO C,NDOS E,MINTHON L. Response to cholinesterase inhibitors affects lifespan in alzheimer’s disease[J/OL].BMC Neurol,2014,14:173[2022-03-01].http://www.biomedcentral.com/1471-2377/14/173.

HOWARD R，MCSHANE R，LINDESAY J，et al.Donepezil and memantine for moderate-to-severe alzheimer’s disease[J].N Engl J Med，2012，366(10): 893-903.

WILCOCK G. Commentary for sequential therapy based on evolvement of patterns：a new model for treatment of alzheimer’s disease[J].Chin J Integr Med，2019，25(8): 563-564.

张学凯，时晶，倪敬年，等.阿尔茨海默病证候级联假说探讨[J].中医杂志，2019，60(9): 741-744.

TIAN J Z，SHI J，NI J N，et al.Sequential therapy based on evolvement of patterns：a new model for treatment of alzheimer’s disease[J]. Chin J Integr Med，2019，25(8): 565-573.

TIAN J Z,SHI J,WEI M Q,et al.Chinese herbal medicine qing gong shou tao for the treatment of amnestic mild cognitive impairment: a 52-week randomized controlled trial[J/OL].Alzheimers Dementia(N Y),2019,5:441-449[2022-03-01].https://doi.org/10.1016/j.trci.2019.03.001.

SHI J,NI J N,LU T,et al.Adding chinese herbal medicine to conventional therapy brings cognitive benefits to patients with alzheimer’s disease:a retrospective analysis[J/OL].BMC Complement Altern Med,2017,17(1):533[2022-03-01].https://pubmed.ncbi.nlm.nih.gov/29237450/.

张介宾.类经[M].郭洪耀，校注.北京：中国中医药出版社，1977: 91.

王清任.医林改错[M].石学文，点校.沈阳：辽宁科学技术出版社，1997: 15.

程国彭.医学心悟[M].图娅，点校.沈阳：辽宁科学技术出版社，1997: 205.

倪敬年，时晶，魏明清，等.中药临床试验中的痴呆分期及辨证标准[J].中华中医药杂志，2017，32(2): 452-454.

时晶，滕羽鸥，魏明清，等.基于认知分级的阿尔茨海默病证候演变规律[J].北京中医药大学学报，2019，42(12): 1038-1042.

陈士铎.辨证录[M].王永谦，点校.北京：人民卫生出版社，1989: 223.

陈士铎.石室秘录[M].张灿玾，点校.北京：中国中医药出版社，1991: 357.

李杲.脾胃论校注[M].程传浩，校注.郑州：河南科学技术出版社，2019: 11.

汪昂.医方集解[M].鲍玉琴，杨德利，校注.北京：中国中医药出版社，1997: 11.

李中梓.本草通玄[M].付先军，校注.北京：中国中医药出版社，2015: 7.

徐树楠，牛兵占.神农本草经：中医经典通释[M].石家庄：河北科学技术出版社，1994: 10.

时晶，倪敬年，司芸芳，等.补肾法治疗阿尔茨海默病的系统评价[J].天津中医药大学学报，2021，40(2): 211-217.

李虹.补脾益肾汤治疗阿尔茨海默病35例[J].中国实验方剂学志，2015，21(5): 193-196.

郑冬冬，李祎鋆，杨月花，等.补肾健脾方联合西药治疗阿尔茨海默病临床观察[J].山西中医，2020，36(8): 27-28.

臧文举，张志军，顾媛媛.补肾化痰益智方联合盐酸多奈哌齐片治疗阿尔茨海默病20例[J].中医研究，2016，29(12): 31-32.

SAVASKAN E，MUELLER H，HOERR R，et al.Treatment effects of ginkgo biloba extract EGb 761 on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials[J].Int Psychogeriatr，2018，30(3): 285-293.

SHI J,WEI M Q,NI J N,et al. Tianzhi granule improves cognition and BPSD of vascular dementia:a randomized controlled trial[J/OL]. J Transl Med,2020,18(1):76[2022-03-01].https://doi.org/10.1186/s12967-020-02232-z.

田金洲，时晶，黄燕，等.阿尔茨海默病的中医诊疗共识[J].中国中西医结合杂志，2018，38(5): 523-529.

时晶，倪敬年，田金洲，等.清热解毒法治疗阿尔茨海默病的系统评价[J].北京中医药大学学报，2019，42(8): 667-672.

顾欣如，王宏洁，杨健，等.黄连解毒汤治疗阿尔茨海默病作用机制研究进展[J].浙江中医药大学学报，2018，42(10): 829-835.

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