Exploration of insomnia of the liver constraint and spleen deficiency pattern from the perspective of gut microbiota-intestine-brain axis

YUN Xiaowen; WU Fengzhi; XU Yifei; WANG Ruochong; ZHANG Yifei; LIU Lanyue; RUAN Kaixia; MA Jie

doi:10.3969/j.issn.2095-6606.2023.03.006

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Exploration of insomnia of the liver constraint and spleen deficiency pattern from the perspective of gut microbiota-intestine-brain axis

Theoretical Exploration | 更新时间：2023-06-06

- Exploration of insomnia of the liver constraint and spleen deficiency pattern from the perspective of gut microbiota-intestine-brain axis
- Modern Chinese Clinical Medicine Vol. 30, Issue 3, Pages: 31-36,42(2023)
- 作者机构：
  
  1.北京中医药大学中医学院　北京　102488
  2.北京中医药大学期刊中心
  3.北京积水潭医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.03.006
  CLC： R241.6
- Published：30 May 2023，
  
  Received：10 September 2022，
- 稿件说明：
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YUN Xiaowen, WU Fengzhi, XU Yifei, et al. Exploration of insomnia of the liver constraint and spleen deficiency pattern from the perspective of gut microbiota-intestine-brain axis. [J]. Modern Chinese Clinical Medicine 30(3):31-36,42(2023)
DOI：

YUN Xiaowen, WU Fengzhi, XU Yifei, et al. Exploration of insomnia of the liver constraint and spleen deficiency pattern from the perspective of gut microbiota-intestine-brain axis. [J]. Modern Chinese Clinical Medicine 30(3):31-36,42(2023) DOI： 10.3969/j.issn.2095-6606.2023.03.006.

摘要

近年来，西医学对于肠道菌群-肠-脑轴的研究不断深入，多个研究提示调节胃肠可以治疗与脑相关的疾病。中医脑与肠胃系统通过经络连接，病理生理关系密切。随着社会的发展和研究深入，肝郁脾虚成为失眠的重要证候，中医中的“肝”“脾”与西医学的神经—内分泌、免疫系统关系密切，与肠道菌群-肠-脑轴及其3条通路相对应。本文从中医理论、肠道菌群-肠-脑轴理论进行分析，提出肝郁脾虚所致的失眠与肠道菌群-肠-脑轴关系密切，其生物学机制可能为“肠道菌群-肠-脑轴”紊乱。

Abstract

In recent years

there has been growing interest in research on "gut microbiota-intestine-brain" axis in modern medicine. Many studies found that gastrointestinal microbiota regulation is beneficial for the treatment of brain-related diseases. In traditional Chinese medicine (TCM)

the brain and gastrointestinal system are connected through meridians

and they are closely related both physiologically and pathologically. In the current society

the liver constraint and spleen deficiency pattern has become one of the dominant types of insomnia. Research has found that the liver and spleen in TCM terms are closely related to the nervous

endocrine and immune systems in modern biology

which correspond to the "gut microbiota-intestine-brain" axis and its three pathways. Based on TCM theory and the theory of "gut microbiota-intestine-brain" axis

we proposed that insomnia caused by liver constraint and spleen deficiency is closely related to the "gut microbiota-intestine-brain" axis

the dysfunction of which might be its potential biological mechanism.

关键词

失眠肠道菌群-肠-脑轴肝郁脾虚证

Keywords

insomnia"gut microbiota-intestine-brain" axisliver constraint and spleen deficiency

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