Discussion on the causal relation between human papillomavirus and cervical cancer from the perspective of damp-heat

WANG Chuyiying; CAO Ying; CHEN Lu; LI Xiaobin; WANG Wenping

doi:10.3969/j.issn.2095-6606.2023.04.018

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Discussion on the causal relation between human papillomavirus and cervical cancer from the perspective of damp-heat

Theoretical Exploration | 更新时间：2023-08-07

- Discussion on the causal relation between human papillomavirus and cervical cancer from the perspective of damp-heat
- Modern Chinese Clinical Medicine Vol. 30, Issue 4, Pages: 84-87(2023)
- 作者机构：
  
  1.辽宁中医药大学　沈阳　110847
  2.辽宁中医药大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.04.018
  CLC： R271.9
- Published：30 July 2023，
  
  Received：13 April 2022，
- 稿件说明：
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WANG Chuyiying, CAO Ying, CHEN Lu, et al. Discussion on the causal relation between human papillomavirus and cervical cancer from the perspective of damp-heat. [J]. Modern Chinese Clinical Medicine 30(4):84-87(2023)
DOI：

WANG Chuyiying, CAO Ying, CHEN Lu, et al. Discussion on the causal relation between human papillomavirus and cervical cancer from the perspective of damp-heat. [J]. Modern Chinese Clinical Medicine 30(4):84-87(2023) DOI： 10.3969/j.issn.2095-6606.2023.04.018.

摘要

宫颈持续感染高危型人乳头瘤病毒(HR-HPV)是宫颈上皮内瘤变(CIN)及宫颈癌的主要危险因素。中医学认为宫颈HR-HPV感染多属湿热，宫颈癌属本虚标实之证，正气虚弱、冲任失调为本，湿热瘀毒凝结为标。西医学认为病毒负荷量增加、免疫功能紊乱、阴道局部微环境改变均可能增加HR-HPV持续感染及宫颈病变进展风险。HR-HPV持续感染是宫颈癌进展过程中的重要因素，临床以湿热证、痰湿证最为常见，清热祛湿是基本的治疗原则，可通过降低机体病毒负荷量、改善机体免疫状态等途径，促进HR-HPV转阴、改善临床症状，进而预防CIN和宫颈癌的发生发展。

Abstract

Persistent infection of high-risk human papillomavirus (HR-HPV) in the cervix is the main risk factor for cervical intraepithelial neoplasia (CIN) and cervical cancer. Traditional Chinese medicine (TCM) believes that cervical HR-HPV infection mostly falls in the category of damp-heat

while cervical cancer is a syndrome of deficiency as the root and excess as the branch

which indicates weakness of healthy qi and disharmony of the

chong

and

ren mai

as the root cause

and congealing of toxin from dampness and heat stasis as the branch. Western medicine believes that increased viral load

immune dysfunction

and changes in local vaginal microenvironment may contribute to HR-HPV persistent infection and consequently increase the risk of developing cervical cancer. Persistent infection of HR-HPV

an important factor in the progression of cervical cancer

is commonly characterized by the patterns of damp-heat and phlegm-damp. Accordingly

the method of clearing heat and dispelling dampness is adopted as the basic treatment principle. By reducing the body’s viral load and improving immunity

it can accelerate the clearing of HPV infections

improve the symptoms

and prevent the occurrence and development of CIN and cervical cancer.

关键词

宫颈癌人乳头状瘤病毒清热祛湿治疗机制

Keywords

cervical carcinomahuman papillomavirusclearing heat and dispelling dampnesstherapeutic mechanism

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