Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions

YANG Yunyue; WANG Wenge; HUAN Chuo; YANG Yue

doi:10.3969/j.issn.2095-6606.2023.05.002

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Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions

Clinical Research | 更新时间：2023-10-12

- Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions
- Modern Chinese Clinical Medicine Vol. 30, Issue 5, Pages: 5-9(2023)
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100700
  2.空军军医大学空军特色医学中心儿科
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.05.002
  CLC： R272
- Published：30 September 2023，
  
  Received：10 February 2023，
- 稿件说明：
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YANG Yunyue, WANG Wenge, HUAN Chuo, et al. Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions. [J]. Modern Chinese Clinical Medicine 30(5):5-9(2023)
DOI：

YANG Yunyue, WANG Wenge, HUAN Chuo, et al. Differences in the expression of inflammatory factors in cord blood in infants with eczema with different TCM constitutions. [J]. Modern Chinese Clinical Medicine 30(5):5-9(2023) DOI： 10.3969/j.issn.2095-6606.2023.05.002.

摘要

目的

探讨不同中医体质类型婴儿湿疹患儿脐血相关炎症因子的表达差异，为客观化湿疹患儿中医体质辨证提供依据。

方法

选取2020年10月至2021年10月于空军军医大学空军特色医学中心出生的健康足月新生儿为研究对象，出生时采集脐带静脉血，并于出生后24～72 h内进行中医体质辨识。42 d时随访根据湿疹发病情况分为正常组及湿疹组，并记录湿疹EASI评分。进一步使用ELISA试剂盒检测脐血中TNF－α、IL－1β、IL－6、IL－25、IL－31、IL－33水平。

结果

收集正常组45例，湿疹组45例，其中平和质、阴盛质及阳盛质各15例。湿疹组脐血IL－1β、IL－6、IL－31、IL－33、TNF－α水平高于正常组，湿疹组脐血IL－25水平低于正常组。进一步亚组分析表明，湿疹阴盛质组脐血IL－1β、IL－6水平低于湿疹平和质组，脐血IL－31、TNF－α水平高于湿疹平和质组。湿疹阳盛质组脐血IL－31、TNF－α水平高于湿疹平和质组，脐血IL－1β、IL－6水平高于湿疹阴盛质组。Spearman相关性分析显示，中医体质评分与IL－1β(

＝0.272，

＝0.009)、IL－6(

＝0.271，

＝0.010)之间呈正相关关系。

结论

湿疹患儿中医体质和炎性因子具有一定关联，可能成为新生儿体质辨识客观化的基础。

Abstract

Objective

To explore the expression difference of inflammatory factors in cord blood of infants with eczema of different TCM constitution types

so as to provide a basis for objectifying TCM constitution differentiation of children with eczema.

Methods

Healthy full-term newborns born at the Air Force Medical Center

PLA

from October 2020 to October 2021 were selected as subjects. Their cord blood was collected at birth

and TCM constitution identification was conducted on them within 24 - 72 hours after birth. At 42 days of follow-up

the infants were divided into the normal group and the eczema group according to the incidence of eczema

and their EASI scores of eczema were recorded. Further detection of TNF-α

IL-1β

IL-6

IL-25

IL-31 and IL-33 levels in the cord blood was conducted by ELISA kit.

Results

45 children were recruited in the normal group and 45 in the eczema group were collected

including the balanced constitution (

=15)

yin excessiveness constitution (

=15) and yang excessiveness constitution (

=15). The levels of IL-1β

IL-6

IL-31

IL-33 and TNF-α in cord blood in the eczema group were higher than those in normal group

while the level of IL-25 in cord blood in eczema group was lower than that in normal group. Further subgroup analysis of the eczema group showed that the levels of IL-1β and IL-6 in cord blood in those with the yin excessiveness constitution were lower than those of children with the balanced constitution

while the levels of IL-31 and TNF-α were higher than that of gentleness group. The cord blood of IL-31 and TNF-α in the yang excessiveness constitution were higher than that of the balanced constitution

while the levels of IL-1β and IL-6 in cord blood were higher than that of yin excessiveness constitution. Spearman correlation analysis showed that there was a positive correlation between TCM constitution score and IL-1β (

=0.272

=0.009)

IL-6 (

=0.271

=0.010).

Conclusion

The TCM constitutions of children with eczema are related to their levels inflammatory factors

which may be the basis for the objectification of newborn constitution identification.

关键词

婴儿湿疹中医体质炎性因子体质辨识

Keywords

infantile eczemaTCM Constitutioninflammatory factorconstitution identification

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