Influence of Tiaomai Mixture on heart rate variability and AF burden in patients with paroxysmal atrial fibrillation and stable coronary heart disease

LI Tengfei; ZHANG Dawei; TIAN Wei; DAI Mei; HAN Yao

doi:10.3969/j.issn.2095-6606.2023.05.007

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Influence of Tiaomai Mixture on heart rate variability and AF burden in patients with paroxysmal atrial fibrillation and stable coronary heart disease

Clinical Research | 更新时间：2023-10-12

- Influence of Tiaomai Mixture on heart rate variability and AF burden in patients with paroxysmal atrial fibrillation and stable coronary heart disease
- Modern Chinese Clinical Medicine Vol. 30, Issue 5, Pages: 35-39(2023)
- 作者机构：
  
  首都医科大学附属北京中医医院　北京　100010
- 作者简介：
- 基金信息：
- DOI：10.3969/j.issn.2095-6606.2023.05.007
  CLC： R256.2
- Published：30 September 2023，
  
  Received：29 October 2022，
- 稿件说明：
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LI Tengfei, ZHANG Dawei, TIAN Wei, et al. Influence of Tiaomai Mixture on heart rate variability and AF burden in patients with paroxysmal atrial fibrillation and stable coronary heart disease. [J]. Modern Chinese Clinical Medicine 30(5):35-39(2023)
DOI：

LI Tengfei, ZHANG Dawei, TIAN Wei, et al. Influence of Tiaomai Mixture on heart rate variability and AF burden in patients with paroxysmal atrial fibrillation and stable coronary heart disease. [J]. Modern Chinese Clinical Medicine 30(5):35-39(2023) DOI： 10.3969/j.issn.2095-6606.2023.05.007.

摘要

目的

观察调脉合剂对阵发性心房颤动合并稳定性冠心病气阴两虚证患者心率变异性及房颤负荷的影响。

方法

采用随机平行对照临床试验，将56例阵发性心房颤动合并稳定性冠心病证属气阴两虚证的患者，随机分组，治疗组30例，对照组26例，2组患者均予常规基础治疗，在此基础上，治疗组患者联合调脉合剂，2组患者均连续治疗4周。对比2组患者心率变异性、房颤负荷及中医证候疗效指标。

结果

经治疗后，2组患者记录全程NN间期的标准差(standard deviation of N-N intervals

SDNN)，相邻NN间期之差的均方根(mean square of successive differences

RMSSD)，高频率范围内NN间期变异(high frequency，HF)均非常明显升高(

0.01)，组间比较差异有统计学意义(

0.01)。LF/HF，房颤负荷均非常明显降低，组间比较差异具有统计学意义(

0.05)；中医证候疗效方面，治疗组总有效率90.0%，对照组总有效率61.5%，治疗组中医症状改善方面，明显优于对照组(

0.05)。

结论

调脉合剂可以提高阵发性心房颤动合并稳定性冠心病气阴两虚证患者迷走神经功能，调节患者自主神经功能平衡，降低房颤负荷，且疗效可靠，无严重不良反应。

Abstract

Objective

To observe the effect of Tiaomai Mixture (Pulse-Regulating Mixture) on heart rate variability and AF burden in patients with paroxysmal AF (PAF) with qi-yin deficiency syndrome and stable coronary heart disease (SCAD).

Methods

In a randomized

controlled

parallel trial

56 patients with PAF

qi-yin deficiency syndrome

and SCAD were randomly divided into 30 in the control group and 26 in the treatment group. Both groups received basic routine treatment

while the treatment group was given additional Tiaomai Mixture. The treatment lasted four weeks. Heart rate variability index

AF burden

TCM syndrome score and adverse reactions were observed.

Results

Heart rate variability indexes

SDNN

RMSSD and HF were improved in both two groups (

0.01)

and the treatment group showed better improvement than the control group (

0.01). LF/HF and AFB decreased significantly in both two groups (

0.05)

and there was significant difference between the two groups (

0.05). In terms of TCM syndrome scores

the total effective rate was 90.0% in treatment group and 61.5% in the control group. The result in the treatment group were superior to those in the control group (

0.05).

Conclusion

Tiaomai Mixture is effective in improving the vagus nerve function

regulating autonomic nerve function and reducing the atrial fibrillation load in patients with paroxysmal AF with qi-yin deficiency syndrome and stable coronary heart disease. No serious adverse reactions.

关键词

调脉合剂心率变异性房颤负荷阵发性心房颤动稳定性冠心病气阴两虚证

Keywords

Tiaomai mixtureatrial fibrillation burdenheart rate variabilityparoxysmal atrial fibrillationstable coronary heart diseaseqi-yin deficiency

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