Primary membranous nephropathy (PMN) is the main cause of adult nephrotic syndrome

with edema as the first manifestation. Abdominal distension

loose stool and other symptoms can be observed in the early and prolonged stages of the disease. Based on clinical experience

it was found that the deficiency of

taiyin

may exist in some patients

so that external wind evil may easily attack the exterior

shaoyin

and further damage the three yin. Therefore

edema occurs in exterior

shaoyin

. A single pathogenesis is in play at the early stage

yet it is still easy for pathogens to enter the inside. If the evil is confined to

taiyin

with qi and blood repressed

the pathogenesis will be complex in the middle and late stages of the disease. Resulting in a series of complications. Then

shaoyin

can be damaged again

causing relapses. The evil may even further spread to

jueyin

leading to the end stage of nephropathy. According to the syndrome differentiation of the six meridians and eight principles

this disease belongs to the combination of

shaoyin

and

taiyin

. Based on the theory of "opening

closing

and pivoting" of the three

yin

the pathogenesis of PMN should be studied with

taiyin

as the base

shaoyin

as the beginning and

jueyin

as the transmission. The idea of treating the kidney by treating the lung and spleen is guided by the concept of "deficiency of

taiyin

" . The main principle is to expel evil and warm the interior. In clinical pracice

Ganjiang Lingzhu Decoction is used to treat the deficiency and cold syndrome of

taiyin

in PMN

which is adjusted based on symptoms and the desirable efficacy can be achieved.