最新刊期
期 5 ， 2021
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- 摘要：ObjectiveTo explore the relationship between chronic gastritis with the spleen-stomach deficiency-cold pattern and the spleen-stomach dampness-heat pattern and gastric acid secretion-related proteins Ezrin-ACAP4-ARF6, and to reveal the intrinsic basis of disease and pattern.MethodsSeventy-nine patients with chronic gastritis were enrolled in a cross-sectional study, including 33 patients with the spleen-stomach deficiency-cold pattern and 46 with the spleen-stomach dampness-heat pattern. The infection of Helicobacter pylori (Hp infection) and erosion under gastroscopy, the results of pathological biopsy of gastric mucosa and the positive expressions of Ezrin, ACAP4 and ARF6 in gastric mucosa were observed.ResultsThere was no significant difference in Hp infection rate between the two groups (P>0.05). The proportion of gastroscope erosion was 60.9% in the spleen-stomach dampness-heat pattern group and 44.5% in the spleen-stomach deficiency-cold pattern, without a statistically significant difference (P>0.05). As for the findings of gastric mucosal pathological biopsy, there was no significant difference between the two groups (P> 0.05). The positive expression rate of ACAP4 was higher in the spleen-stomach deficiency-cold pattern group than in the spleen-stomach dampness-heat pattern group, and the difference was significant between the two groups (P< 0.05). In the spleen-stomach deficiency-cold pattern group, there was no significant difference in the expressions of Ezrin, ACAP4 and ARF6 in different pathological stages(P>0.05). The expression levels of ACAP4 and ARF6 were significantly higher in the dysplasia stage(P< 0.05).ConclusionsThe expression level of gastric acid secretion related protein Ezrin-ACAP4-ARF6 was higher in chronic gastritis patients with the spleen-stomach deficiency-cold pattern than with the spleen-stomach dampness-heat pattern, the expression level of Ezrin remained unchanged in the process of pathological evolution, and the expression levels of ACAP4 and ARF6 were increased in the stage of dysplasia, which revealed the different internal material basis of the two patterns.关键词：chronic gastritis;spleen-stomach deficiency-cold pattern;spleen-stomach dampness-heat pattern;combination of disease and pattern;gastric acid secretion;Ezrin-ACAP4-ARF6
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发布时间：2021-10-19 - 摘要：ObjectiveTo observe the clinical efficacy of heat-sensitive point moxibustion combined with the biofeedback therapy for the treatment of dyssynergic constipation of the lung and spleen qi-deficiency pattern.MethodsSixty outpatients were randomly assigned to the treatment group (30 cases) and control group (30 cases).The treatment group was treated with heat-sensitive point moxibustion combined with biofeedback therapy, while the control group was treated only with biofeedback therapy. The clinical efficacy, constipation symptom severity score, TCM syndrome score, resting anal sphincter pressure (RASP), squeeze anal sphincter pressure(SASP), anal sphincter relaxation rate (ASRR), first rectal sensation(FRS), constant rectal sensation(CRS) and maximum rectal tolerable sensation(MRTS) were observed.ResultsBefore and after treatment, the curative effect was better in the treatment group than in the control group (P<0.05). After treatment, the scores of incomplete sensation of defecation, defecation time and times of no defecation were significantly lower in the treatment group than in the control group, the scores of sweating shortness, fatigue after defecation, mental fatigue and lazy speech were significantly lower in the treatment group than in the control group, and differences of symptom score between the two groups before and after treatment were statistically significant (P<0.05). The differences of ASRR, FRS and CRS between the two groups before and after treatment were statistically significant (P<0.05), better in the treatment group than in the control group. One month follow-up showed that the curative effect of the treatment group was better than that of the control group (P<0.05), the scores of defecation difficulty, sweating shortness, fatigue after defecation, mental fatigue and lazy speech were significantly higher in the control group than in the treatment group, and differences of score between the two groups in one month follow-up and after treatment were statistically significant (P<0.05). ConclusionsThe therapy of heat-sensitive point moxibustion combined with biofeedback can significantly improve clinical symptoms, asynergic movement of pelvic floor muscles as well as rectal sensation in the treatment of patients, with stable curative effect.关键词：heat-sensitive point moxibustion technology;biofeedback therapy;dyssynergic constipation;lung and spleen qi deficiency pattern
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发布时间：2021-10-19 - 摘要：ObjectiveTo observe the clinical efficacy of kidney-tonifying blood-activating collateral-unblocking method for thin endometrium of the kidney deficiency and blood stasis pattern.MethodsSixty-eight patients with thin endometrium were randomly assigned to the treatment group (34 cases) and the control group (34 cases). With the withdrawal and drop-outs excluded, there were 30 cases in the treatment group and 30 cases in the control group. The treatment group was treated with modified Bushen Huoxue Tongluo Decoction, and the control group was treated with Estradiol Valerate and Progesterone Capsule. Endometrial thickness, endometrial type, endometrial blood flow type, resistant index(RI)and pulse index(PI) value of endometrial blood flow, RI and PI value of uterine artery and TCM symptom score were observed.ResultsThe endometrial thickness was thicker after treatment than before treatment in both groups, and the differences were statistically significant (P<0.05). After treatment, the proportion of type A endometrium was higher in the treatment group than in the control group, and the proportion of type C endometrium was lower in the treatment group than in the control group, and the differences were statistically significant (P<0.05). After treatment, the endometrial blood flow types of the two groups were improved, as compared with those before treatment (P<0.05), better in the treatment group than in the control group, and the differences were statistically significant (P<0.05). RI and PI of endometrial blood flow in the treatment group were lower after treatment, than before treatment (P<0.05), and RI and PI of uterine artery blood flow in the two groups were lower than before treatment (P<0.05).The menstrual volume and menstrual time scores were lower after treatment than before treatment in both groups, and the differences were statistically significant (P<0.05). In the treatment group, the scores of menstrual color, waist and knee soreness, dizziness, tinnitus and abdominal pain were lower after treatment than before treatment, and the differences were statistically significant (P<0.05). After treatment, the symptoms and total scores were significantly lower in the treatment group than in the control group, and the differences were statistically significant (P<0.05).ConclusionsThe kidney-tonifying blood-activating collateral-unblocking method has a good clinical effect in the treatment of thin endometrium of the kidney deficiency and blood stasis pattern.关键词：kidney-tonifying blood-activating collateral-unblocking method;thin endometrium;kidney deficiency and blood stasis pattern;clinical efficacy
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发布时间：2021-10-19 - 摘要：ObjectiveTo observe the effect of auricular point pressing combined with beans for the dry eyes.MethodsOne hundred and twenty cases with mild and moderate dry eyes were included and randomly divided into the treatment group (n=60) and the control group(n=60). The control group received 0.1% Sodium hyaluronate eye drops while the treatment group received auricular pressure& beans in addition to the treatment of the control group. Fluoresce staining(FL), schirmer I test (SIT), break-up time of tears(BUT) and tear meniscus height(TMH) were observed.ResultsThe BUT values were significantly higher after treatment than before treatment in both groups, and the FL values were significantly lower after treatment than before treatment in both groups (P<0.05). BUT value was significantly higher in the treatment group than in the control group, and FL value was significantly lower in the treatment group than in the control group (P< 0.05), better in the treatment group than in the control group. SIT and TMH values in the treatment group were higher after treatment than before treatment, and the differences were statistically significant(P<0.05).ConclusionsAuricular point pressing combined with beans can improve FL status of patients with dry eyes, increase SIT, BUT and TMH.关键词：dry eyes;auricular point pressing combined with beans;clinical;randomized controlled
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发布时间：2021-10-19 - 摘要：ObjectiveTo observe the cognitive function in patients with temporal lobe epilepsy (TLE), and to explore the correlation between TCM constitution types and TLE and their cognitive function.MethodsA total of 98 TLE patients were enrolled for cognitive tests and TCM constitution types tests, from the neurology ward and outpatient of TCM Department at Xuanwu Hospital of Capital Medical University from October 2018 to January 2020. Montreal Cognitive Assessment (MoCA) scores and TCM constitution types between the TLE group and normal group(n=30) were observed.ResultsThere were significantly lower scores in MoCA and visuospatial and executive, memory, attention, language in patients with TLE(P<0.01). As compared with the normal group, patients with the constitution of qi deficiency and with the dampness-heat constitution outnumbered those with other types in the TLE group (P<0.05). In the TLE group with normal cognitive ability, patients with the peaceful constitution outnumbered those with other types(P<0.01); in the TLE group with the cognitive impairments, the qi deficiency constitution was more than other types(P<0.05).ConclusionsThe cognitive function of patients with TLE was significantly reduced, which was reflected in visuospatial and executive ability, attention, language ability and memory. From the comparison of the nine TCM constitutions, qi deficiency and dampness-heat constitutions are more common in patients with TLE, and qi deficiency patients are more likely to suffer cognitive impairments.关键词：temporal lobe epilepsy;cognitive impairments;Montreal Cognitive Assessment(MoCA);TCM constitution type
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发布时间：2021-10-19 - 摘要：ObjectiveTo explore the clinical efficacy of toxin-discarding and tissue-regenerating method for ulcerative lymph node tuberculosis.MethodsSixty patients with ulcerative lymph node tuberculosis were randomly assigned to the treatment group (n=30) and the control group (n=30). There were 30 cases in the treatment group and 26 cases in the control group, with the withdrawal or drop-outs excluded. The treatment group was treated with compound Wufengcao Liquid in addition to the conventional treatment, and the control group was treated with No.Ⅱ Dan on the basis of the conventional treatment. The clinical efficacy of the two groups, clinical sign scores, the wound healing rate, the time to decompose the wound, and the pain intensity of dressing change were observed.ResultsIn terms of the clinical efficacy, of the 30 cases in the treatment group, 14 cases were cured, 14 cases improved, 2 cases were ineffective, with a total effective rate of 93.3%; of the 26 cases in the control group, 11 cases were cured and 13 cases improved, 2 cases were ineffective, with a total effective rate of 92.3%. After rank sum test, Z=-2.45, P=0.034, P<0.05, it indicates that the efficacy was higher in the treatment group than in the control group. As for the scores of TCM syndromes, in the two groups, the scores of TCM syndromes improved more in the treatment group than in the control group, and the difference was statistically significant (P<0.01). As for the wound healing rate, the healing rate was higher in the treatment group than in the control group, and the difference was statistically significant (P<0.01). As for the time of wound decay, the time of wound decay was shorter in the control group than in the treatment group, and the difference was statistically significant (P<0.05). As for the pain intensity of dressing change, the pain intensity of dressing change was significantly lower in the treatment group than in the control group, and the difference was statistically significant (P<0.05).ConclusionsThe toxin-discarding and tissue-regenerating method has good clinical effects in the treatment of ulcerative lymph node tuberculosis.关键词：ulcerative lymph node tuberculosis;toxin-discarding and tissue-regenerating;external treatment;clinical efficacy;wound healing
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发布时间：2021-10-19 - 摘要：ObjectiveTo observe the therapeutic effect of modified Diyu Powder in the treatment of oral mucositis of yin deficiency and heat toxin pattern in patients undergoing targeted lung cancer treatment.MethodsFifty lung cancer patients with oral mucositis were randomly divided into the experimental group and control group, 25 cases in each group. The control group received compound chlorhexidine combined with routine treatment, and the experimental group took modified Diyu powder orally. The classification of oral mucositis, the TCM syndrome score and Karnofsky’s performance scale(KPS) were observed in the two groups.ResultsThe classification of oral mucositis was lower after treatment than before treatment in both groups(P< 0.05), with better improvement in the treatment group than in the control group. The scores of TCM syndromes were lower after treatment than before treatment in both groups(P< 0.01), significantly lower in the treatment group than in the control group. There was a significant before-after-treatment difference in KPS in the treatment group(P< 0.01), and there was a significant before-after-treatment difference in KPS between the treatment group and the control group (P< 0.05).ConclusionsModified Diyu Powder can improve the reaction of oral mucositis and the quality of life of lung cancer patients.关键词：modified Diyu powder;lung cancer;targeted therapy;oral mucositis;quality of life
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发布时间：2021-10-19 - 摘要：Alcoholic liver disease (ALD) refers to a kind of liver diseases caused by long-term heavy drinking. In the early stage, it is often manifested as alcoholic fatty liver disease, which may further develop into alcoholic hepatitis, alcoholic liver fibrosis and alcoholic cirrhosis. Severe alcoholism may lead to extensive hepatocyte necrosis and induce liver failure. Professor Tian Delu has studied digestive diseases for more than 50 years. He has profound understanding and rich clinical experience on the mechanism, prevention and treatment of alcoholic liver disease. He divides ALD into three stages, namely, early stage, middle stage and advanced stage. He focuses on the liver, spleen and kidney for syndrome differentiation and treatment. In the early stage, alcohol poisoning injures the liver and affects the spleen and stomach. The external cause of the disease is alcohol toxin and dampness-heat. Disharmony of the liver and spleen, stagnation of Qi and dampness are the initial pathogenesis. The key points of the treatment are to harmonize the liver and spleen, alleviate a hangover and remove toxin. In the middle stage, both the liver and spleen are injured, and phlegm and blood stasis are blocking. The aggregation of qi, blood and phlegm dampness is the pathogenesis of the middle stage. The key of treatment is to regulate the liver, regulate qi, resolve phlegm and remove blood stasis. In the advanced stage, involvement of the liver and spleen affects the kidney, resulting in a mixture of deficiency and excess. It is the pathogenesis of the advanced stage that the deficiency-excess mixing leads to alcoholic tympanites. The focus of the treatment is to treat both manifestations and root cause of the disease and to use both dredging and supplementation.关键词：Tian Delu;alcoholic liver disease;famous physician’s experience;traditional Chinese medicine
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发布时间：2021-10-19 - 摘要：Polycystic Ovary Syndrome (PCOS) is a common clinical reproductive endocrine and metabolic disease. According to its clinical manifestations, traditional Chinese medicine (TCM) often classifies PCOS as amenorrhea, delayed menorrhea, hypomenorrhea, infertility or other diseases. At present, the treatment of PCOS in TCM mostly starts with the regulation of the liver, spleen and kidney. Prof. Guo Zhiqiang proposes to treat PCOS by the therapeutic method of TihuJiegai( lifting the pot and removing the lid: resolving the lung), from the regulation of the lung.Tihu Jiegai method is mainly applicable to two patterns in PCOS, namely, "failure of the lung to declare and downbear, resulting in the accumulation of phlegm and dampness" and "the stagnation of lung qi, resulting in stagnation of qi and blood stasis" . Tihu Jiegai method is mainly a method of diffusing the lung by using pungent and divergent medicines clinically. In addition, the spleen- and blood-nourishing products are often used to protect qi and blood.关键词：polycystic ovary syndrome;treatment from the lung;therapeutic method of Tihu Jiegai;famous physician’s experience;Guo Zhiqiang
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发布时间：2021-10-19 - 摘要：Professor Guo Weiqin’s clinical prescriptions for treating heart diseases is mainly centered on the methods of invigorating qi and activating blood circulation, with distinctive features in the use of blood-activating and stasis-removing medicines. Danshen root (Radix et Rhizoma Salviae Miltiorrhizae)&safflower(Radix et Rhizoma Ginseng Rubra), and turmeric root tuber(Radix Curcumae)& wenyujin rhizome(Rhizoma Wenyujin Concisum) are frequently used medicinals in Guo Weiqin’s prescriptions. In the above coupled medicinals, cold and heat medicinals are used simultaneously, which makes her medications even and balanced. The special three-medicine combinations are Euonymi twig(Ramulus Euonymi), turmeric root tuber(Radix Curcumae) and bitter orange(Fructus Aurantii), curcumae rhizome (Rhizoma Curcumae), kelp (Thallus Laminariae) and thunberg fritillary bulb (Bulbus Fritillariae Thunbergii). The combination of the former three medicinals agrees with the theory of qi and blood homology, which is suitable for patients with coronary heart diseases and angina pectoris. The latter treats severe atherosclerotic plaques. Professor Guo Weiqin is also good at using other blood-activating medicinals, such as Sichuan lovage rhizome(Rhizoma Chuanxiong), bugleweed(Herba Lycopi)and so on.关键词：Guo Weiqin;promoting blood circulation to remove blood stasis;heart disease;clinical experience
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发布时间：2021-10-19 - 摘要：Scapulohumeral periarthritis corresponds to "Bi syndrome" in traditional Chinese medicine. Patients with this disease suffer a lot, and their daily life is often greatly disturbed, with lowered life quality. Professor Wang Qingguo has rich experience in the treatment of scapulohumeral periarthritis. He believes that scapulohumeral periarthritis is mostly caused by cold evil, and he emphasizes that the cold gathering in the meridians is its core pathogenesis. In clinical practice, Professor Wang often uses the classic prescription Gegen Decoction to treat scapulohumeral periarthritis. It has good results regardless of etiological factors, whether it is caused by exogenous contraction or internal injuries. Professor Wang has formed a unique system of differentiation and treatment, with featured dosages and addition and subtraction. Based on the typical cases of clinical treatment of exogenous scapulohumeral periarthritis and internal injury scapulohumeral periarthritis, this paper introduces the diagnosis and treatment ideas and medication experience of Professor Wang in the treatment of scapulohumeral periarthritis.关键词：famous TCM physician’s experience;Gegen Decoction;scapulohumeral periarthritis;Bi syndrome;cold gathering in the meridians;WANG Qingguo
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发布时间：2021-10-19 - 摘要：Professor Luo Songping has been working in TCM gynecology for more than 30 years. In clinical practice, based on yin-yang theory, taking the kidney-Tiangui-Chongren-uterine axis as the core of menstrual regulation, with the kidney and spleen as the fundamentals, Professor Luo nourishes and tonifies the kidney to balance yin and yang, and strengthens the spleen and qi, to nourish blood and regulate menstruation. In clinical practice, according to ages and stages of the menstrual cycle, Professor Luo uses the methods of nourishing yin, tonifying yang, regulating qi and promoting blood circulation flexibly. With regard to the geographic characteristics of Lingnan, he has created seasonal extracts and has made good use of the local herbal medicine, so as not to make the menstruation-regulating medicine greasy or dry. He has formed unique ideas for menstrual regulation, with good effects.关键词：menstrual regulation;kidney and spleen as fundamentals;famous physician’s experience;Luo Songping
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发布时间：2021-10-19 - 摘要：ObjectiveTo systemically evaluate the validity and safety of Shenqi Jiangtang Agent combined with dipeptidy l peptidase 4 inhibitors for type 2 diabetes mellitus.MethodsRandomized controlled trials (RCT) of Shenqi Jiangtang Agent combined with DPP-4 inhibitors for the treatment of type 2 diabetes mellitus were collected from China National Knowledge Infrastructure(CNKI), Chinese Science and Technology Journal Database (VIP), China Biomedical Literature Database (CBM), Wan Fang Database (Wan Fang), PubMed, Embase, Cochrane Library and other databases. According to the inclusion and exclusion criteria and the Cochrane bias risk assessment tool, two researchers independently conducted literature screening and methodological quality evaluation. RevMan 5.3 software was used to analyze the data of the included studies.ResultsA total of 8 RCT studies were included with a total of 843 patients, including 422 patients in the Shenqi Jiangtang Agent combined with DPP-4 inhibitors group(treatment group) and 421 patients in the DPP-4 inhibitors group(control group). The total effective rate was better in the treatment group than in the control group (RR=1.19, 95%CI[1.09, 1.30], P<0.000 1); the treatment group had a better efficacy in reducing fasting blood glucose than the control group (MD=-1.62, 95%CI[-1.80, -1.44], P<0.000 01); the effect of reducing blood glucose 2 hours after a meal was better in the treatment group than in the control group (WMD=-1.01, 95%CI[-1.15, -0.86], P<0.000 01); the efficacy of HbA1c was more significantly reduced in the treatment group than in the control group (MD=-1.23, 95%CI[-1.41, -1.04], P<0.000 01); the treatment group had better insulin resistance index reduction than the control group (MD=-0.79, 95% CI[-0.87, -0.71], P<0.000 01). The improvement of pancreatic β-cell function index was better in the treatment group than in the control group (MD=12.45, 95% CI[11.31, 13.59], P<0.000 01). The decrease of IL-6 was better in the treatment group than in the control group (MD=-9.60, 95%CI[-10.21, -9.00], P<0.000 01). The incidence of adverse reactions was significantly lower in the treatment group than in the control group (RR=0.32, 95%CI[0.17, 0.58], P=0.000 2<0.05).ConclusionsShenqi Jiangtang Agent combined with DPP-4 inhibitors has a better therapeutic efficacy for type 2 diabetes mellitus than DPP-4 inhibitors, with a remarkably lower incidence of adverse reactions in the Shenqi Jiangtang Agent combined with DPP-4 inhibitors group than in the DPP-4 inhibitors group. More high-quality, large-scale samples, multi-center RCTs are needed in the future to verify the clinical efficacy and safety of Shenqi Jiangtang Agent combined with DPP-4 inhibitors in the treatment of for type 2 diabetes mellitus.关键词：Shenqi Jiangtang Agent;dipeptidy l peptidase 4 inhibitor;type 2 diabetes mellitus;randomized controlled trial;meta-analysis
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发布时间：2021-10-19 - 摘要：Chronic cough induced by cold stimulation is common clinically. TCM physicians of all dynasties have emphasized that the etiology of prolonged cough is mostly stasis, cold, wind, deficiency, as well as coordinated work of internal and external colds. Our research team believes that cold cough induced by cold stimulation is characterized by internally and externally combined pathogens, zang-fu organ relevance, and deficiency-excess complex. Transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential melastatin 8(TRPM8) cold sensory channels are involved in many links leading to the increased cough sensitivity, which may be one of the material bases for the pathogenesis of cold cough of chronic cough.关键词：cold stimulation;chronic cough;cold cough;etiology and pathogenesis;transient receptor potential channel
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发布时间：2021-10-19 - 摘要：Parkinson’s disease belongs to the neurodegenerative disease of the nervous system, and has not only motor symptoms such as bradykinesia, tremors and myotonia, but also non-motor symptoms such as sleep disorders, mental disorders, autonomic nervous dysfunction and sensory disorders. The trembling symptom is consistent with the core symptom of Parkinson’s disease. The main pathogenesis of Parkinson’s disease is unsmooth flow of gallbladder qi and Sanjiao stagnation. It has been found in clinical practice that Chaihu Jia Longgu Muli Decoction (Bupleuri Radix plus Longgu Muli Decoction) can improve the symptoms of patients with Parkinson’s disease, with remarkable effect.关键词：harmonizing Shaoyang;unsmooth flow of gallbladder qi;Sanjiao stagnation;Parkinson’s Disease;Chaihu Jia Longgu Muli Decoction
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发布时间：2021-10-19 - 摘要：In recent years, the signaling pathway from the intestine to the brain has attracted much attention as a non-negligible influencing factor in ischemic stroke. Intestinal flora is involved in the generation of high-risk pathogenic factors in ischemic stroke. Traditional Chinese medicine believes that the brain and intestines are closely connected physiologically through the meridians, and functionally they nourish and regulate each other; pathologically, encephalopathy may affect the intestines, and intestinal diseases may affect the brain, and the two influence each other. Based on this understanding, the regulation of intestinal flora stabilization can be used as an entry point to study the treatment of ischemic stroke. At present, the treatment methods of traditional Chinese medicine including the active ingredients of traditional Chinese medicine, the monomer of traditional Chinese medicine, the compounds of traditional Chinese medicine and acupuncture are adopted. Some progress has been made in regulating the intestinal flora to improve the occurrence, development and prognosis of ischemic stroke. This article reviews the prevention and treatment of ischemic stroke based on intestinal flora in traditional Chinese medicine.关键词：traditional Chinese medicine;intestinal flora;ischemic stroke;review
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发布时间：2021-10-19
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