最新刊期
期 4 ， 2023
- 摘要：COVID-19 has seriously threatened people’s health as well as social and economic development. Traditional Chinese medicine has certain advantages in the prevention and treatment of the disease. This article discusses the etiology, pathogenesis and principles of differentiation and treatment of COVID-19 in detail based on the Traditional Chinese Medicine Diagnosis and Treatment Plan for COVID-19 of Beijing (the seventh Trial Edition). According to traditional Chinese medicine (TCM), COVID-19 belongs to the category of "pestilence" . The etiology of COVID-19 infection is comprehensive. 2019 novel coronavirus (SARS-CoV-2) is the main pathogenic factor. While climate, season and other external environmental factors and personal constitutions are important factors affecting the occurrence of the disease. The core pathogenesis of COVID-19 is dampness toxin stagnation. Influenced by climate, location, individual constitutions, treatment and other factors, the characteristics of disease transmission and prognosis are often different among various population groups. When identifying the pathogenesis, a comprehensive analysis should be made from the perspectives of disease nature, location, tendency, duration, and pathology. The diagnosis and treatment of COVID-19 should adhere to the basic strategy of combining "one formula for one disease" and "one formula for one person" . The four basic principles of treatment are early treatment, eliminating evil, replenishing healthy qi, and prevention of progress of disease.关键词：Coronavirus disease 2019 (COVID-19);etiology and pathogenesis;principle of differentiation and treatment;The Traditional Chinese Medicine Diagnosis and Treatment Plan for COVID-19 of Beijing
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发布时间：2023-08-07 - 摘要：Coronavirus disease (COVID-19) is a highly transmissible disease characterized by sudden onset, rapid transmission, and high susceptibility. Prof. Liu Qingquan believes that, in TCM terms, COVID-19 falls in the category of dampness toxin epidemic in epidemic febrile disorders, caused by pestilent qi of dampness toxin, which can be mixed with seasonal pathogens and possibly complicated by heat, cold and dryness due to geographical and physical differences. He stresses that dampness is the branch while toxin is the root. The core pathogenesis includes dampness, toxin, heat, phlegm, stasis, and deficiency. The diagnosis and treatment for the disease should prioritize staged treatment, identifying the root, and stopping and reversing progression. In response to the constituents of the disease mechanism and their progressive nature, we apply the method of dispelling dampness, resolving toxins, clearing heat, unblocking the bowels, increasing body fluids, cooling blood, invigorating blood, and supplementing deficiency. The focus has been placed on the integration of both TCM and modern pharmaceuticals so that they complement each other for the sake of optimal efficacy, the combined use of classic formulas and novel ones, and acupuncture, moxibustion and daoyin as supplements.关键词：COVID-19;staged treatment;identifying roots causes by examining syndromes;stopping and reversing disease progression;eliminating dampness and resolving toxins
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发布时间：2023-08-07 - 摘要：In the past three years of the COVID-19 pandemic, traditional Chinese medicine has been involved in the prevention and treatment for the viral disease since the beginning of the outbreak, and has made remarkable achievements. This study summarized the progress and existing problems of clinical research of traditional Chinese medicine for COVID-19, and proposed strategies for future TCM studies in case of public health emergency in relation to communicable diseases, to inform practice and policy. Evidence shows that traditional Chinese medicine has potential benefits in COVID-19 prevention, treatment and recovery, may help to reduce the infection rate of close contacts, reduce the viral load; improve the symptoms, relieve inflammation, reduce the rate of progression into severe cases, and shorten the time for viral clearance; improve gastrointestinal and respiratory symptoms and lung function in patients after COVID-19. Although large number of TCM studies on COVID-19 have been published, most of the evidence is of low quality. Therefore, more multi-center, large-sample, placebo-controlled, double-blind randomized controlled trials and related systematic reviews and meta-analyses are needed in the future.关键词：COVID-19;clinical research evidence;traditional Chinese medicine
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发布时间：2023-08-07 - 摘要：Case reports in traditional Chinese medicine (TCM) format are important records of TCM clinical practice and the fundamental literature for experience discussion and inheritance. There are no standards regarding reporting structure and content, which had led to the appreciable variability in reporting quality, and also had complicated the efficacy and safety assessment. Here we propose to categorize TCM case reports into 2 genres, namely, the instructive and the structured reports respectively. Quality assessment based on modern standards (eg. the CARE checklist) was suggested to apply to structured reports, paralleled with TCM theoretical discussion. Disease-oriented evaluation is also an important aspect. For example, as to instructive reports of COVID-19, TCM discussion including fundamental theories, principles, formulas and herbs should be the emphasis, while quality evaluation is not mandatory. As to structured reports of COVID-19, aside from the quality evaluation based on the CARE checklist, describing the clinical classification and prognostic factors is highly necessary. The importance of rigorous statement reflecting TCM’s independent therapeutic effect should be stressed.关键词：case reports;reporting quality;COVID-19
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发布时间：2023-08-07 - 摘要：ObjectiveTo analyze the TCM patterns of interstitial lung disease (ILD) with corona virus disease 2019, and explore its etiology and pathogenesis.MethodsA cross-sectional study was conducted, in which 69 ILD patients diagnosed with COVID-19 in our hospital’s outpatient and wards from December 2022 to January 2023 were included. Their four TCM diagnostic information, general conditions and clinical data of western medicine were collected on the first visit or the day of admission.ResultsAmong the 69 patients, the initial manifestation was predominantly lung-wei syndrome, accompanied by spleen syndromes. 23 symptoms were recorded from the 69 patients. Compared with the mild and moderate cases, the proportion of dyspnea, chest tightness, incomplete defecation, fear of cold, aversion of wind, blood in sputum, dry coating on the tongue and thready pulse in severe and critical patients was significantly higher (P < 0.05); while the proportion of headaches was significantly low (P< 0.05). Among the 69 patients, there were 3 types of tongue body, and 6 types of tongue coating and pulse pattern, respectively. Compared with mild and moderate patients, the proportion of dry coating on the tongue and thready pulse was higher in severe and critical patients (P<0.05). Among the 69 patients, 50 (72.5%) had a mixture of deficiency and excess, while 19 (27.5%) had excess patterns. From the perspective of zang-fu organ syndrome differentiation, there were a total of 12 syndrome types. Compared with the mild and moderate patients, the proportion of kidney-qi deficiency, kidney-yin and yang deficiency, heat entering ying-blood and pestilence blocking the lung in severe and critical patients was significantly higher (P<0.05). The proportion of cold-dampness stagnation in the lung was significantly lower (P<0.05). The affected area of the 69 patients is mainly located in the lung and spleen. Compared with the mild and moderate patients, the proportion of affected area in the kidney and ying-blood level is higher in severe and critical patients (P < 0.05).ConclusionCOVID-19 is caused by the contraction of pestilence qi. COVID-19 in ILD patients can be manifested as the predominance of dampness toxin. The pathogenesis involves two parts: deficiency of healthy qi (in the lung, spleen, kidney) and excess of evil qi (damp heat toxin). The onset of the disease is in the lung wei, and it common moves to the lung and spleen in the progressive stage. In severe and critical cases, the kidney and ying-blood may also be involved.关键词：ILD;COVID-19;symptoms;TCM patterns;etiology and pathogenesis
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发布时间：2023-08-07 - 摘要：ObjectiveTo analyze the symptoms and TCM syndrome characteristics of patients infected with the Omicron variant of COVID-19 in Beijing, in order to provide a theoretical and scientific basis for better understanding and treatment of the disease.MethodsA cross-sectional study was conducted, in which a total of 217 severe cases of COVID-19 infection with Omicron variant strain in Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University and Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from December 2022 to January 2023 were reviewed. General patient information, including gender, age, smoking history, symptoms, signs, comorbidities, and past medication history, and also manifestations in terms of the four TCM methods of diagnosis was collected.ResultsAmong the 217 patients at high risk for COVID-19 infections, those with combined cardiovascular and cerebrovascular diseases were the most frequent, with 191 cases. Among the respiratory system manifestations, cough, phlegm, chest tightness and cardiothoracic symptoms appeared more frequently. In terms of other TCM dominant symptoms, peripheral sensory abnormalities appeared most frequently, accounting for 99.08%, while digestive system symptoms were mostly seen in abdominal distension and loss of appetite, and mental symptoms were seen in abnormal sleep and mental abnormalities. In terms of urination and defecation, the main symptoms were dysuria and loose stools. The tongue color was mainly light red (33.18%) and light white (30.41%), and light dark tongue (11.52%) was rare; the tongue body was fat (20.28%). Tongue coating was mainly thin (31.80%), greasy (29.95%), and yellow (28.57%). Slippery pulse (38.71%), thready pulse (27.19%), weak pulse (25.81%), and deep pulse (24.42%) were the most common. In terms of TCM symptoms, lung-qi deficiency was the most frequent (34.10%), followed by qi-yin deficiency (24.42%) and evil-heat stagnation in the lung (17.51%).ConclusionThe TCM syndrome of the severe cases infected with the Omicron variant of COVID-19 were mainly qi deficiency in the lung and spleen and deficiency of both qi and yin.关键词：COVID-19 infection;severe illness;high-risk groups;omicron variant strains;characteristics of TCM syndromes
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发布时间：2023-08-07
COVID-19
- 摘要：Shaoyang is the pivot of qi and blood, regulating their movement and distribution. Shaoyang is also the pivot of meridians and collaterals, regulating the generation, entering and exiting of yang qi. Moreover, shaoyang is the pivot of the zang-fu organs, regulating the ascending and descending of qi. Therefore, disturbance at the pivot may lead to triple consequences: first, qi and blood deficiency and disharmony between ying and wei qi; second, yang deficiency, yin stagnation and blockage in uterus vessels; third, disharmony among the zang-fu organs and disturbance of qi movement. Deficiency, cold accumulation and qi stagnation are the primary causes of gynecological diseases. Professor Wang Qingguo proposes that the root cause of gynaecopathia is disturbance of shaoyang, and the treatment should be based on its regulation. The first step to do so should be harmonizing ying and wei qi, with great importance attached to generating yang qi and the simultaneous regulation of the liver and spleen. The flexible use of the bupleurum-based formulas in the treatment of menstrual diseases, leukorrheal diseases and other gynecological diseases has been proven to be remarkably effective.关键词：shaoyang as the pivot;gynecological diseases;academic thoughts;famous physician’s experience;WANG Qingguo
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发布时间：2023-08-07 - 摘要：Percutaneous coronary intervention (PCI) is a common method for clinical treatment of coronary heart disease, but patients are prone to postoperative chest pain and other types of discomfort, for which there are currently no effective measures. Professor Guo Weiqin has developed unique insights into the diagnosis and treatment of chest pain after PCI. She believes that toxin, stasis and deficiency are the key contributing factors of the pain, and, based on this theory, proposed an innovative way of staged prevention and treatment. The method of boosting qi and invigorating blood is used throughout the treatment, with special focus placed on clearing heat and removing toxins in the early stage after operation, activating blood and removing stasis in the middle, and supplementing and invigorating healthy qi in the later stage.关键词：postoperative treatment of percutaneous coronary intervention;chest pain;famous physicians’ experience;Guo Weiqin
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发布时间：2023-08-07
Renowned TCM Doctors’ Experience
- 摘要：ObjectiveTo investigate the influencing factors of standard empirical syndrome differentiation in patients with primary glomerulonephritis using logistic regression analysis.MethodsA retrospective study was conducted on 417 patients with primary glomerular disease who were admitted to the Department of Nephrology at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine, the Department of Nephrology at Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine, and the Department of Nephrology at the Seventh People’s Hospital affiliated to Shanghai University of Traditional Chinese Medicine for concurrent biopsy and pathological examination. Random multiclass logistic regression correlation analysis was used to analyze the correlation between 35 independent variables such as primary glomerular disease markers and renal histopathological changes and biochemical indicators.ResultsThere were 184 patients with non-standard empirical evidence, 233 with standard empirical evidence (including combined standard empirical evidence), 156 with water dampness syndrome, 65 with dampness heat syndrome, and 9 with blood stasis syndrome. Those with non-standard empirical evidence were used as a control, and the influencing factors of water dampness syndrome differentiation are: 24-hour urine protein quantification (P < 0.05), showing a positive correlation, hemoglobin (P <0.05), negatively correlated, serum albumin (P<0.05), showing a negative correlation. The influencing factor of dampness heat syndrome differentiation is serum albumin (P<0.05), which is negatively correlated. The influencing factor of blood stasis syndrome differentiation is the integral of glomerular cell proliferation degree (P<0.05), which is positively correlated.ConclusionThe influencing factors for the differentiation of water dampness syndrome in patients with primary glomerulonephritis are 24-hour urine protein quantification, hemoglobin, and serum albumin. The influencing factor for the differentiation of dampness heat syndrome is serum albumin, while the influencing factor for the differentiation of blood stasis syndrome is the degree of glomerular cell proliferation integral.关键词：primary glomerular disease;TCM syndrome types;standard empirical evidence;renal pathology;biochemical indicators
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发布时间：2023-08-07 - 摘要：ObjectiveTo observe the clinical efficacy of acupuncture in the treatment of hand-foot syndrome (HFS).Methods20 patients with HFS were selected and given patient education and acupuncture (bilateral) for 3 weeks. Their efficacy and grading of HFS, HFS symptom scores, quality of life scores and safety were observed before and after treatment.ResultsAfter 3 weeks of treatment, 2 cases were cured, 12 cases were effective, and the total effective rate was 70%. After treatment, the scores of numbness, tingling sensation, insensitivity, burning sensation, pain, erythema, desquamation, pigmentation and swelling decreased significantly (P < 0.05). As for the EORTC QLQ-C30 score after treatment and before treatment, physical function, role function, emotional function, social function, fatigue, pain, loss of appetite, overall quality of life dimension scores were significantly improved (P < 0.05).ConclusionAcupuncture has a good clinical effect on HFS.关键词：hand-foot syndrome;acupuncture;treatment;cancer
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发布时间：2023-08-07
Clinical Research
- 摘要：The idea of jiàn pí mó jī (fortifying the spleen and dissipating accumulation) was first proposed in Jingui Yaolve (Essentials from the Golden Cabinet), which is an important part of the theory of traditional Chinese medicine. Chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) belongs to the category of "accumulation syndrome" in TCM terms, which is characterized by long courses of disease, difficulty to cure, and a pattern of deficiency as the root and excess as the branch. To be specific, its root lies in deficiency of the spleen and stomach, while toxins resulting from binding of phlegm and stasis damage the collaterals, which is the branch of the disease. Aiming at the pathogenesis of accumulation syndromes and the etiology, pathogenesis and disease characteristics of CAG with IM, we adopt the theory of "fortifying the spleen and dissipating accumulation" and propose the method of strengthening the spleen and boosting qi, nourishing yin and boosting the stomach, moving qi and resolving constraint, invigorating blood and unblocking the collaterals, resolving dampness and removing toxins, for the diagnosis and treatment of the disease.关键词：fortifying the spleen and dissipating accumulation;chronic atrophic gastritis with intestinal metaplasia;treatment according to pattern differentiation
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发布时间：2023-08-07 - 摘要：Primary deep venous insufficiency (PDVI) refers to venous valvular incompetence in the lower limbs without the presence of deep vein thrombosis, which leads to deep venous blood flowing backwards into the veins below the knee and even to the ankle, thus causing a series of venous stagnation symptoms. Based on the clinical manifestations and characteristics of PDVI, it can be classified as "edema" in traditional Chinese medicine (TCM). The blood-vessel syndrome differentiation theory explains the disease using vessels, which is one of the extraordinary fu organs, and the ying qi, wei qi, liquids and blood vessels inside and outside vessles. The basic pathogenesis of PDVI can thus be regarded as the deficiency of qi in the vessels, which is the root of the disease, and the obstruction caused by dampness and stasis as the symptoms. Therefore, the basic treatment method for PDVI is to boost qi and drain dampness, nourish blood and unblock vessels. This study provides some ideas for pattern differentiation and treatment of PDVI together with several clinical cases.关键词：primary deep venous insufficiency;blood-vessel syndrome differentiation;traditional Chinese medicine
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发布时间：2023-08-07 - 摘要：In recent years, the detection of clinical pulmonary nodules has shown an increasing trend, and the long follow-up time and the difficulty of judging whether the nodules are benign and malignant are the primary difficulties. The theory of liver and lung correlation is an important part of the five viscera theory, and the two are closely related both physiologically and pathologically. They affect each other and synergize in the ascending or descending movement of qi and the flow of qi and blood. Pulmonary nodules are not recorded in ancient books of traditional Chinese medicine, but they can be categorized into "fei ji" (lung accumulation) since they are tangible lesions that follow a specific law of development. The key to its generation and progression is constraint of liver qi and damage of lung qi leading to disorder of qi movement and blood in the liver and lung. For the treatment of pulmonary nodules, the main methods are to soothe the liver, rectify the lung and promote qi movement, supplemented by softening hardness and dissipating mass, resolving stasis and toxin, and strengthening the resistance to eliminate pathogenic factors. For the treatment of clinical symptoms of pulmonary nodules, it is necessary to pay special attention to diffusing and restoring the smooth movement of lung qi, soothing the stagnated liver qi, restoring the balance of ascending and descending functional activities of qi, so that the whole qi-blood circulation can function smoothly, and paying attention to psychological counseling for patients. Combined with clinical cases, the treatment of pulmonary nodules from the theory of correlation of lung and liver is introduced.关键词：pulmonary nodules;correlation of the lung and liver;pathogenesis;traditional Chinese medicine
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发布时间：2023-08-07 - 摘要：The term xiongbi (chest impediment) refers to a disease characterized by severe chest pain, even involving the back in severe cases, accompanied by sleeplessness due to dyspnea. Both traditional Chinese and Western medicine believe that there are "blockages" in this disease. Xuanfu (pore) is the most microscopic channel structure of qi and liquid circulation in the human body. The heart can play the role as the governor of the blood and vessels in the body only when Xinxuanfu (heart pore) is unobstructed. Chest impediment is a disease caused by obstruction of the heart collaterals. From a microscopic point of view, it can be regarded as obstruction of heart pores. Keeping them unobstructed is thus vital to the normal movement of heart qi. Wind-dispelling medicinals or wind herbs, can open the xuanfu, discharge the striae and interstices externally and interact with the zang-fu organs internally. It has been clinically proven that wind-dispelling drugs can open the xuanfu by regulating qi, dissolving stasis, dissipating cold, or dispeling phlegm.关键词：xinxuanfu (heart pore);opening pores with wind-dispelling medicinals;xiongbi (chest impediment)
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发布时间：2023-08-07 - 摘要：Chronic atrophic gastritis (CAG) is a common chronic disease and precancerous disease of the digestive system. Gastric atrophy accompanied by intestinal metaplasia and dysplasia is a precancerous lesion of gastric cancer. Patients with intestinal-gastric cancer generally go through a process of "inflammation-carcinoma transformation" with clearly defined progressive stages. It is a slow process with dynamic and reversible characteristics, which provides a special window of opportunity to inhibit the progression of the disease. The main intervention means of pregastric cancer is Helicobacter pylori eradication, followed by drug therapy. The intervention of CAG should be a comprehensive but personalized process of chronic disease management. In the standardized disease management, traditional Chinese medicine (TCM) elements are contained in every step and staged management is needed under the guidance of the TCM ideal of "treating the disease before it arises" . Prevention is the first level of disease management, mainly aimed at asymptomatic patients or people with relieved symptoms. Controlling the development of existing disease is the second and key level of disease management, which requires strict control of risk factors for gastric cancer and regular monitoring of disease progression. Finally, recurrence must be avoided. The benefit evaluation of chronic disease management for "inflammation-carcinoma transformation" in stomach should be patient-oriented, focus on the whole course, long-term prospect and fully explain the advantages of integrated Chinese and Western medicine to the patient.关键词：chronic atrophic gastritis;precancerous lesions of gastric cancer;histopathology;intervention of traditional Chinese medicine;chronic disease management
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发布时间：2023-08-07
Ideas and Methodologies
- 摘要：The term "Jin Ye Zi He" (autonomous recovery of body fluids) was first seen in Shanghanlun (Treatise on Cold Damage), which suggests that the body returns to its normal state of sweating and urination. This is the basis for maintaining the balance of yin and yang in the body, and also an important prerequisite for resisting and eliminating pathogenic factors. In the broad sense, Jin Ye (body fluids) refers to the general body fluids of various types and their metabolites, and plays an important role in the occurrence, development and prognosis of externally contracted febrile diseases. The loss of harmony of body fluids includes abnormal body fluid volume, transpiration and transformation, and abnormal flow and distribution. The theories of cold damage, warm diseases and pestilence explain externally contracted febrile diseases from different angles. Although the three are different syndrome differentiation systems, they agree on the development trend of the disease from the shallow to the deep and from the outside to the inside. Children have fast metabolism, higher demand for body fluids, and therefore the tendency to experience imbalance in body fluids, which suggests that they are more likely to have body fluid loss than adults. For the treatment, it is proposed to relieve and diffuse the exterior, clear heat and promote fluid production, and restore the smooth movement of qi, to achieve autonomous recovery of body fluids, dispel evil and restore healthy qi. The methods to do so include treating superficies syndrome with sweat promotion using pungent and warm herbs, relieving exterior syndrome with pungent-cool drugs to dispel evil with sweat, clearing internal heat, nourishing yin to facilitate fluids production and removing dampness and heat, to aid the movement of qi.关键词："Jin Ye Zi He";(autonomous recovery of body fluids);externally contracted febrile diseases in children;Shanghanlun (Treatise on Cold Damage);febrile diseases
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发布时间：2023-08-07 - 摘要：Hyperthyroidism is a syndrome that is caused by excessive secretion of thyroid hormone characterized by hypermetabolism and increased body excitability. The theory of Body, Qi and Spirit in TCM are closely related to the etiology and pathogenesis of the condition. Disturbance of the spirit is the internal factor of hyperthyroidism, dysfunction in the regulation of qi movement is the fundamental cause of the disease, and phlegm with blood stasis is the key factor of the disease progression. In the treatment of hyperthyroidism, attention should be paid to calming the mind by regulating the heart and liver, regulating the qi, for which the key is to restore the free qi movement, and dissolving the form by dispelling stasis and removing phlegm with both internal and external treatment.关键词：body, qi and spirit;hyperthyroidism;pathogenesis;treatment
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发布时间：2023-08-07 - 摘要：Persistent infection of high-risk human papillomavirus (HR-HPV) in the cervix is the main risk factor for cervical intraepithelial neoplasia (CIN) and cervical cancer. Traditional Chinese medicine (TCM) believes that cervical HR-HPV infection mostly falls in the category of damp-heat, while cervical cancer is a syndrome of deficiency as the root and excess as the branch, which indicates weakness of healthy qi and disharmony of the chong and ren mai as the root cause, and congealing of toxin from dampness and heat stasis as the branch. Western medicine believes that increased viral load, immune dysfunction, and changes in local vaginal microenvironment may contribute to HR-HPV persistent infection and consequently increase the risk of developing cervical cancer. Persistent infection of HR-HPV, an important factor in the progression of cervical cancer, is commonly characterized by the patterns of damp-heat and phlegm-damp. Accordingly, the method of clearing heat and dispelling dampness is adopted as the basic treatment principle. By reducing the body’s viral load and improving immunity, it can accelerate the clearing of HPV infections, improve the symptoms, and prevent the occurrence and development of CIN and cervical cancer.关键词：cervical carcinoma;human papillomavirus;clearing heat and dispelling dampness;therapeutic mechanism
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发布时间：2023-08-07 - 摘要：Huiyin (CV1) is the first point on the ren mai (aka conception vessel), and also the meeting point of the du mai (aka governor vessel) and chong mai (aka thoroughfare vessel). Because Huiyin is located in the private part of the body, treatment focusing on this point is not very common. By referring to ancient literature and clinical experience, we conclude that the functions of Huiyin include tonifying yin, nourishing blood, soothing the liver, directing counterflow qi downward and harmonizing the conception and thoroughfare vessels, which are further illustrated by clinical case records in this study.关键词：Huiyin (CV1);clinical application;three vessels stemming from one source
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发布时间：2023-08-07 - 摘要：The term "scaly dry skin" was first seen in Chapter for Blood Impediment and Consumptive Diseases in Jingui Yaolve (Essentials from the Golden Cabinet), which states that "blood depletion is the internal cause of scaly dry skin" . Therefore, the symptom has since been generally regarded as an external symptom of blood stasis inside the body. However, it has been discovered in clinical practices that scaly dry skin is not only found in patients with blood stasis syndrome, suggesting that it is inappropriate to provide a diagnosis based solely on this symptom alone and then choose the method of invigorating blood and removing blood stasis. Scaly dry skin can also be seen in yellow sweating, intestinal abscess, lung abscess, subcutaneous fluid retention, and the syndrome of heat accumulation in middle-jiao. Its pathogenesis is essentially lack of nourishment of qi and blood or insufficient body fluids unable to moisten and nourish the skin. Targeting at these patterns or diseases, various treatment methods should be adopted, such as invigorating blood and removing blood stasis, nourishing qi and eliminating dampness, removing abscess and evacuating pus, clearing away heat accumulation, and releasing the exterior and clearing retained fluid. The aim is to restore the free flow of qi and blood and normal distribution of body fluids, so that they can moisten and nourish the skin and remove the symptom of scaly dry skin as a result.关键词：scaly dry skin;static blood;TCM classics;qi, blood and body fluid
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发布时间：2023-08-07 - 摘要：Jingxiutang Yiyuan Jingzhi is a classic on medical theories and discussions written by Yu Shiyong, a doctor in the Ming Dynasty. He treated spleen and stomach diseases in his own unique ways by observing the pathogenesis, attaching importance to phlegm and blood, focusing on phlegm-dampness in excess and blood deficiency in deficiency syndromes. He preferred mild and common prescriptions, paying attention to their flexible use, and he was good at using single-herb formulas, for he believed the effects can be concentrated in simpler recipes. He always followed the guidance of five evolutive phases and six climatic factors in his selection of herbal ingredients. Warming and supplementing herbal drugs were predominantly used in his clinical practice, while medicine-induced stagnation was carefully avoided. Yu was also a master of using paradoxical assistant herbs to harmonizes the actions of all medicinals in a formula. He proposed to adopt both internal and external methods for treatment and pays special attention to the way in which drugs were prepared and taken. He believed that pulse diagnosis was of vital importance and doctors should combine pulse manifestations with symptoms in trying to determine the roots of diseases. By analyzing the characteristics of Yu’s treatment of spleen and stomach diseases, this study aims to aid the clinical treatment of spleen and stomach diseases and studies on Yu’s academic thoughts.关键词：Jingxiutang Yiyuan Jingzhi;Yu Shiyong;academic thought;spleen and stomach disease
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发布时间：2023-08-07
Theoretical Exploration
- 摘要：ObjectiveTo investigate the effect and mechanism of Qingdu Suppository (Toxin-Clearing Suppository) on cervical cancer in vitro and in vivo based on cell apoptosis and immune regulation.Methods(1) Cell experiment: SiHa cells were divided into blank serum groups at various concentrations (5%, 10%, 15%, 20%, respectively) and dosed serum groups at various concentrations (5%, 10%, 15%, 20%, respectively). The CCK8 method was employed to investigate the effects of different serum concentrations on SiHa cell activity. Flow cytometry was then used to detect the apoptosis and cycle distribution of the cells treated with 15% dosed serum for 72 h. (2) Animal experiment: A tumor bearing mouse model of cervical cancer was established. The mice were divided into cervical cancer control group (PBS buffer gavage), Qingdu Suppository low-dosage group (14.4 g/kg gavage) and Qingdu Suppository high-dosage group (28.8 g/kg gavage) by random number table method, with 6 mice in each group. The intervention lasted for 28 days. The tumor volume and body weight were recorded. The proliferation and apoptosis of tumor tissues in the three groups were detected via Ki67 assay and Tunel assay, respectively, and the expression of T cell subtypes in tumor tissues of the three groups were detected by flow cytometry.ResultsThe cell experiment showed that the dosed serum could inhibit the activity of SiHa cells, with the 15% and 20% dosed serum exhibiting the strongest inhibitory effect when the cells were treated for 72 h, and there was no significant difference between the two groups. Compared with the 15% blank serum group, apoptotic cells increased in the 15% dosed serum group. Cells in phase G0/G1 increased and those in phase S and G2/M decreased in dosed serum, the differences were statistically significant (P < 0.01). The animal experiment showed that compared with the control group, the proportion of Ki67 positive cells in the tumor tissues of the two Qingdu Suppository groups decreased while Tunel positive cells increased, and the changes in the high-dosage group were more prominent with the differences being statistically significant between the two groups (P<0.01). Compared with the control group, the proportion of Th1 and Th17 cells in peripheral blood of mice in the high-dosage group increased, the proportion of Th2 and Treg cells decreased, and the proportion of Th1/Th2 and Th17/Treg increased, with the differences being statistically significant (P<0.05).ConclusionThe optimal dosage of Qingdu Suppository to inhibit SiHa cell activity is 15% for 72 hours. Qingdu Suppository may inhibit cervical cancer by promoting apoptosis of cancer cells. This may also be achieved by regulating drift of Th2 to Th1, inhibiting Treg cells and relieving immunosuppression through immune microenvironment.关键词：Qingdu Suppository;cervical cancer;apoptosis;Th1/Th2;Th17/Treg
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发布时间：2023-08-07
TCM Clinical and Basic Studies
- 摘要：TCM professionals are currently faced with demanding work, emotional exhaustion and overwhelming burdens in their medical career, which easily increases their work stress, leading to compassion fatigue and job burnout. As an effective countermeasure, narrative medicine has focused on the expression and empathy needs of TCM practitioners. Through our narrative medicine practices in TCM hospitals, we created a space for expression and communication among patients, medical professionals, and administrators. By letting people tell their own stories and listen to others, narrative medicine helps to facilitate better understanding of their roles, clarify the responsibility in the doctor-patient relationship, and improve empathy and teamwork. This helps the current healthcare environment move toward a more flexible and humanistic model of modern medicine that is co-constructed by doctors and patients, providing comprehensive professional support across personal, workplace, and social levels.关键词：narrative medicine;work stress;compassion fatigue;job burnout
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发布时间：2023-08-07
Narrative Medicine
- 摘要：Primary angiitis of the central nervous system (PACNS) is a severe immunoinflammatory disease mainly affecting small and medium blood vessels in the brain parenchyma, spinal cord and pia mater. Due to its rarity and heterogeneity, effective treatment strategies are currently lacking. In this study, the disease progression was not halted in the patient with PACNS after pulse glucocorticoid therapy and immunosuppressive therapy. In the adjuvant treatment with TCM, the overall principle was to dispel pathogen and reinforce healthy qi, prioritizing the differentiation between the manifestations and root causes and identification of the primary problems. It was consequently found that phlegm and heat were the main pathogenic factors, and the core pathogenesis change was pathogenic excess evolving into deficiency of healthy qi. The first step adopted was to dispel pathogen by clearing heat, eliminating phlegm, and opening the orifices. Qi-nourishing and deficiency-supplementing herbs were used later when the patient’s progression started to slow down. After TCM treatment, the patient’s conditions gradually improved, and remarkable efficacy was achieved, which provided a new perspective for TCM treatment of PACNS.关键词：primary angiitis of the central nervous system;traditional Chinese medicine;dispelling pathogen and reinforcing healthy qi
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发布时间：2023-08-07
Case Reports
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