Objective To discuss the pathogenic factors of hypertension on the base of TCM constitution science.Method The multiple Logistic regression analysis was carried out in hypertension patients in the case group（n=271） and those without hypertension in the control group（n=302） by applying case-control study of clinical epidemiology.The correlative degree between relevant constitutional factors and hypertension was explored.Result There were 3 constitutional factors enclosed in the regression equation

including mild constitution

phlegm-damp constitution and blood-stasis constitution.The partial regression coefficients were -0.602

1.437 and 0.592 respectively.Conclusion The risk factors of hypertension include phlegm-damp constitution and blood-stasis constitution.The phlegm-damp constitution is more important in the onset of hypertension and mild constitution is a protective factor.