Objective To observe the clinical efficacy of Yijing Decoction plus Levocarnitine and Coenzyme Q10 (CoQ10) for asthenospermia of the spleen-kidney deficiency pattern.Methods 68 patients with asthenospermia of the spleen-kidney deficiency pattern were randomly assigned to the treatment group and control group

with 34 cases in each group.After shedding cases were removed

there were 33 left in each group.The patients in the control group were treated with Levocarnitine Oral Solution and CoQ10 Pill while the patients in the treatment group additionally received Yijing Decoction in addition to the Western medical treatment.The progressive motility (PR)

total motility (progressive+non-progressive motility

PR+NP)

clinical efficacy

TCM syndrome score and therapeutic effect of TCM syndromes were observed.Results After treatment

PR and PR+NP in both groups were significantly increased

as compared with that before treatment and the differences were statistically significant (P<0.05).PR and PR+NP were more markedly elevated in the treatment group than in the control group

and the differences in scores before and after treatment in both groups were statistically significant (P<0.05)

better in the treatment group than in the control group.Among the 33 patients in the treatment group

9 were cured

10 were significantly effective

8 were effective and 6 were ineffective

the total number of effective cases was 27 and the total effective rate was 81.81%.In the control group

there were 5 cured cases

3 obvious cases

9 effective cases and 16 ineffective cases

the total number of effective cases was 17

and the total effective rate was 51.52%.After rank sum test

Z=-2.754

P=0.006

P<0.05

the clinical efficacy of the treatment group was better than that of the control group.After treatment

TCM syndrome scores of the two groups were lower than those before treatment

and the differences were statistically significant (P<0.05)

significantly lower in the treatment group than in the control group (P<0.05).Among the 33 patients in the treatment group

9 were cured

3 were significantly effective

16 were effective and 5 were ineffective.With a total of 28 effective cases

the total effective rate was 84.85%.In the control group

there was no cured case

1 obvious case

14 effective cases and 18 ineffective cases.With a total of 15 effective cases

the total effective rate was 45.46%. Rank sum test showed Z=-4.077

P=0.000 (P<0.01)

indicating that the therapeutic effect of TCM syndromes was better in the treatment group than in the control group.Conclusions Yijing Decoction plus Levocarnitine and CoQ10 has good effects on asthenospermia of the spleen-kidney deficiency pattern. Abstract