Epilepsy is a commondisease which is difficult to cure. It seriously threats lives and affects daily living.The theory of wu-shenzang is a high generalization of the relationship between fivespiritsand the five-zangorgans

which embodies the core theory of TCM on Holistic Thinking. We can adjust the abnormal spirits to restore the function of the five-zang organs and vice versa. The pathogenesis ofepilepsy is complicated

butwehavefoundthatitisrelatedtothistheory in TCM. Based on the unique theory

we proposed the "syndrome differentiation system of five spirits -five-zang organs -fiveepilepsies" tomatch the characteristics of spirits and the five-zang organ lesions with those of epileptic seizures. This system can help restore the balance of yin and yang to get better treatment for epilepsy. This paper could provide a new idea for treating epilepsy in TCM.