基于数据挖掘分析中医治疗非小细胞肺癌EGFR-TKIs腹泻用药规律

范振佳; 黄金昶; 周慧锋; 郝迎旭

doi:10.3969/j.issn.2095-6606.2021.03.013

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基于数据挖掘分析中医治疗非小细胞肺癌EGFR-TKIs腹泻用药规律

文献研究 | 更新时间：2021-08-23

- 基于数据挖掘分析中医治疗非小细胞肺癌EGFR-TKIs腹泻用药规律
- Medication rules of TCM treatment of EGFR-TKIS related diarrhea in non-small cell lung cancer based on data mining
- 现代中医临床 2021年28卷第3期页码：59-63,76
- 作者机构：
  
  1.北京中医药大学第三附属医院　北京　 100029
  2.北京市朝阳区平房社区卫生服务中心
  3.中日友好医院中西医结合肿瘤内科
- 作者简介：
  
  范振佳，女，在读博士生
  # 郝迎旭，女，主任医师，硕士生导师，E-mail：haoyingxu@126.com
- 基金信息：
  
  国家自然科学基金面上项目(82074545);北京中医药薪火传承“3+3”工程张代钊名医传承工作站建设项目(2007-SZ-C-12)
- DOI：10.3969/j.issn.2095-6606.2021.03.013
  中图分类号： R273
- 纸质出版日期：2021-05-30，
  
  收稿日期：2020-11-20，
- 稿件说明：
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范振佳, 黄金昶, 周慧锋, 等. 基于数据挖掘分析中医治疗非小细胞肺癌EGFR-TKIs腹泻用药规律[J]. 现代中医临床, 2021,28(3):59-63,76.

Zhenjia Fan, Jinchang Huang, Huifeng Zhou, et al. Medication rules of TCM treatment of EGFR-TKIS related diarrhea in non-small cell lung cancer based on data mining[J]. Modern Chinese Clinical Medicine, 2021,28(3):59-63,76.
范振佳, 黄金昶, 周慧锋, 等. 基于数据挖掘分析中医治疗非小细胞肺癌EGFR-TKIs腹泻用药规律[J]. 现代中医临床, 2021,28(3):59-63,76. DOI： 10.3969/j.issn.2095-6606.2021.03.013.

Zhenjia Fan, Jinchang Huang, Huifeng Zhou, et al. Medication rules of TCM treatment of EGFR-TKIS related diarrhea in non-small cell lung cancer based on data mining[J]. Modern Chinese Clinical Medicine, 2021,28(3):59-63,76. DOI： 10.3969/j.issn.2095-6606.2021.03.013.

摘要

目的

挖掘分析中医治疗非小细胞肺癌EGFR-TKIs相关腹泻的用药规律。

方法

检索中国知网数据库、万方数据知识服务平台及维普中文期刊服务平台，收集、筛选相关文献，应用古今医案云平台V2.2.3版，对中医证候、中药频次、四气、五味、归经等进行分类统计，分析配伍规律，并进行聚类分析。

结果

中医证候频次最高的是气阴两虚证；中药使用频次最高的是黄芪，其次为白术与茯苓；用药以性平、味甘、归脾胃肺经的中药为主；得到六对频次及可靠度均较高的药物组合，层次聚类分析得到两大类共4组药物，均以益气养阴，健脾化痰为主要功效。

结论

非小细胞肺癌EGFR-TKIs相关腹泻以气阴两虚、脾弱痰蕴为病机特点，常见中医证候为气阴两虚证，治疗以益气养阴，健脾化痰为主，用药以性平、味甘、脾胃肺经药物为主。

Abstract

Objective

To explore and analyze the medication law of traditional Chinese medicine in the treatment of EGFR-TKIs associated diarrhea (epidermal growth factor receptor

EGFR; tyrosine kinase inhibitors

TKIs) in non-small cell lung cancer.

Methods

Related literature was retrieved from CNKI

Wan Fang(WF) and VIP databases. TCM syndromes

TCM frequency

four qi

five flavors

tropism

etc. were counted

compatibility rules were analyzed and cluster analysis with ancient and modern medical case cloud platform V2.2.3. was conducted.

Results

The highest frequency of TCM syndromes was deficiency of qi and Yin. Astragalus membranaceus was most frequently used

followed by atractylodes and Poria cocos. The main medicinals were medicinals that had a neutral nature

a sweet taste and those which were attributive to the spleen

stomach and lung meridians. Six drug combinations with high frequency and reliability were obtained

and four groups of medicinals in two categories were obtained

all of which had the main effects of enhancing qi and nourishing Yin

strengthening spleen and resolving phlegm.

Conclusions

Diarrhea associated with EGFR-TKIS of non-small cell lung cancer is characterized by the deficiency of qi and Yin and the accumulation of phlegm in the spleen

and the common TCM syndromes are the deficiency of qi and Yin. The treatment focuses on promoting qi and nourishing Yin

strengthening the spleen and resolving phlegm

and the commonly used medicinals are medicinals with a neutral nature

a sweet taste and attributive to the spleen

stomach and lung meridians.

关键词

靶向药物非小细胞肺癌EGFR中医治疗数据挖掘

Keywords

targeted drugsnon-small cell lung cancerepidermal growth factor receptortreatment in traditional Chinese medicine

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