Objective

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To analyze the medication rules of TCM compound in the treatment of chronic gastritis with the help of Chinese medicine inheritance auxiliary system

and to provide the basis for clinical prescription and new drug development.

Methods

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Compound patents for chronic gastritis during 2015-2020 were retrieved in the Chinese medicine inheritance auxiliary system(V2.5). The frequency of traditional Chinese medicine

the meridians of traditional Chinese medicine and the flavor of medicinal herbs were counted

the rules of traditional Chinese medicine compound patents were analyzed by using the method of association rules.Core drug combinations were extracted based on complex system entropy clustering

and candidate new prescriptions were obtained by unsupervised entropy hierarchical clustering.

Results

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A total of 126 TCM prescriptions for the treatment of chronic gastritis were included

involving 157 medicinals

and 21 medicinals with frequency≥20.Most frequently used medicinals were Radix Paeoniae Alba(white peony root)

Rhizoma Coptidis(coptis rhizome)

Rhizoma Atractylodis Macrocephalae(white atractylodes rhizome)

Radix Aucklandiae(common aucklandia root)

Fructus Aurantii (bitter orange)

Pericarpium Citri Reticulatae(aged tangerine peel)and so on.Those medicinals were mainly attributive to the Spleen

Stomach and Liver meridians.Those medicinals were warm and cold in nature

and bitter

pungent and sweet in flavor.The commonly used paired medicinals were Radix Paeoniae Alba(white peony root)and Rhizoma Atractylodis Macrocephalae(white atractylodes rhizome)

Rhizoma Corydalis(corydalis rhizome) and Radix Aucklandiae(common aucklandia root)

Radix Paeoniae Alba(white peony root) and Radix Aucklandiae(common aucklandia root)

Radix Paeoniae Alba(white peony root) and Radix Aucklandiae(common aucklandia root)

etc. And the commonly-used three-medicinal combinations were white atractylodes rhizome

white peony root and common aucklandia root

white atractylodes rhizome

white peony root and villous amomum fruit

white atractylodes rhizome

villous amomum fruit and bitter orange. Based on association rules

15 groups of high-frequency herb combinations were revealed

for instance

"Corydalis corydalis→Fructus Aurantii→ Atractylodes"

"Amomum kernel→Poria cocos→Atractylodes"

"Paeoniae peony→Amoy kernels→Atractylodes" and "Amoy kernels→Fructus Aurantii→Atractylodes" .Twenty-four groups of core TCM combinations were obtained based on complex system entropy clustering.And 12 new prescriptions were mined based on unsupervised entropy hierarchical clustering analysis.

Conclusions

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TCM is flexible in the treatment of chronic gastritis. The core TCM combination and new candidate prescriptions involve regulating qi and invigorating the spleen

transforming dampness and harmonizing the stomach

promoting blood circulation and relieving pain

transforming food and protecting the stomach

etc.