慢性胃炎脾胃虚寒证、脾胃湿热证与Ezrin-ACAP4-ARF6的相关性研究
Correlation between chronic gastritis with spleen-stomach deficiency-cold pattern and spleen-stomach dampness-heat pattern and Ezrin-ACAP4-ARF6
- 现代中医临床 2021年28卷第5期 页码：2-7
- 作者机构：
1.北京中医药大学东直门医院 北京 100700
2.北京中医药大学东方医院
3.北京中医药大学
- 作者简介：
孟涵，女，在读硕士生
# 丁霞，女，教授、主任医师，博士生导师，E-mail：dingx@bucm.edu.cn
- 基金信息：国家自然科学基金资助项目(81630080)
DOI：10.3969/j.issn.2095-6606.2021.05.002
中图分类号： R259纸质出版日期：2021-09-30，
收稿日期：2021-03-27，
- 稿件说明：
移动端阅览
孟涵, 李园, 刘福生, 等. 慢性胃炎脾胃虚寒证、脾胃湿热证与Ezrin-ACAP4-ARF6的相关性研究[J]. 现代中医临床, 2021,28(5):2-7.
Han Meng, Yuan Li, Fusheng Liu, et al. Correlation between chronic gastritis with spleen-stomach deficiency-cold pattern and spleen-stomach dampness-heat pattern and Ezrin-ACAP4-ARF6[J]. Modern Chinese Clinical Medicine, 2021,28(5):2-7.
孟涵, 李园, 刘福生, 等. 慢性胃炎脾胃虚寒证、脾胃湿热证与Ezrin-ACAP4-ARF6的相关性研究[J]. 现代中医临床, 2021,28(5):2-7. DOI： 10.3969/j.issn.2095-6606.2021.05.002.
Han Meng, Yuan Li, Fusheng Liu, et al. Correlation between chronic gastritis with spleen-stomach deficiency-cold pattern and spleen-stomach dampness-heat pattern and Ezrin-ACAP4-ARF6[J]. Modern Chinese Clinical Medicine, 2021,28(5):2-7. DOI： 10.3969/j.issn.2095-6606.2021.05.002.
摘要
目的
2
探讨慢性胃炎脾胃虚寒证、脾胃湿热证与胃酸分泌相关蛋白Ezrin-ACAP4-ARF6的关系，揭示证候内在物质基础。
方法
2
采用横断面研究方法收集79例慢性胃炎患者，其中脾胃虚寒证组33例，脾胃湿热证组46例。观察Hp感染和胃镜下伴糜烂情况，胃黏膜病理活检结果，胃黏膜Ezrin
ACAP4及ARF6阳性表达情况。
结果
2
2组Hp感染率比较，差异无统计学意义(
P
>
0.05)；脾胃湿热证组胃镜下伴糜烂比例为60.9%，脾胃虚寒证组为45.5%，差异无统计学意义(
P
>
0.05)。2组胃黏膜病理活检结果比较，差异无统计学意义(
P
>
0.05)。脾胃虚寒证组ACAP4阳性表达率高于脾胃湿热证组，差异有统计学意义(
P
<
0.05)。脾胃虚寒证组各病理阶段Ezrin
ACAP4及ARF6表达水平差异均无统计学意义(
P
>
0.05)。脾胃湿热证组ACAP4与ARF6均在异型增生阶段表达水平较高，差异有统计学意义(
P
<
0.05)。
结论
2
慢性胃炎脾胃虚寒证患者胃酸分泌相关蛋白Ezrin-ACAP4-ARF6表达水平较脾胃湿热证升高，Ezrin在病理演变过程中表达水平无显著变化，ACAP4与ARF6在异型增生阶段表达水平升高，揭示了2个证候的不同内在物质基础。
Abstract
Objective
2
To explore the relationship between chronic gastritis with the spleen-stomach deficiency-cold pattern and the spleen-stomach dampness-heat pattern and gastric acid secretion-related proteins Ezrin-ACAP4-ARF6
and to reveal the intrinsic basis of disease and pattern.
Methods
2
Seventy-nine patients with chronic gastritis were enrolled in a cross-sectional study
including 33 patients with the spleen-stomach deficiency-cold pattern and 46 with the spleen-stomach dampness-heat pattern. The infection of Helicobacter pylori (Hp infection) and erosion under gastroscopy
the results of pathological biopsy of gastric mucosa and the positive expressions of Ezrin
ACAP4 and ARF6 in gastric mucosa were observed.
Results
2
There was no significant difference in Hp infection rate between the two groups (
P
>
0.05). The proportion of gastroscope erosion was 60.9% in the spleen-stomach dampness-heat pattern group and 44.5% in the spleen-stomach deficiency-cold pattern
without a statistically significant difference (
P
>
0.05). As for the findings of gastric mucosal pathological biopsy
there was no significant difference between the two groups (
P
>
0.05). The positive expression rate of ACAP4 was higher in the spleen-stomach deficiency-cold pattern group than in the spleen-stomach dampness-heat pattern group
and the difference was significant between the two groups (
P
<
0.05). In the spleen-stomach deficiency-cold pattern group
there was no significant difference in the expressions of Ezrin
ACAP4 and ARF6 in different pathological stages(
P
>
0.05). The expression levels of ACAP4 and ARF6 were significantly higher in the dysplasia stage(
P
<
0.05).
Conclusions
2
The expression level of gastric acid secretion related protein Ezrin-ACAP4-ARF6 was higher in chronic gastritis patients with the spleen-stomach deficiency-cold pattern than with the spleen-stomach dampness-heat pattern
the expression level of Ezrin remained unchanged in the process of pathological evolution
and the expression levels of ACAP4 and ARF6 were increased in the stage of dysplasia
which revealed the different internal material basis of the two patterns.
关键词
慢性胃炎脾胃虚寒证脾胃湿热证病证结合胃酸分泌Ezrin-ACAP4-ARF6
Keywords
chronic gastritisspleen-stomach deficiency-cold patternspleen-stomach dampness-heat patterncombination of disease and patterngastric acid secretionEzrin-ACAP4-ARF6
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