慢性咳嗽寒咳证中医病因病机及物质基础探讨

范钰晗; 史利卿; 马建岭; 王丽云; 季坤; 王颖; 罗敬月

doi:10.3969/j.issn.2095-6606.2021.05.015

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慢性咳嗽寒咳证中医病因病机及物质基础探讨

思路与方法 | 更新时间：2021-10-19

- 慢性咳嗽寒咳证中医病因病机及物质基础探讨
- Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine
- 现代中医临床 2021年28卷第5期页码：65-68
- 作者机构：
  
  1.北京中医药大学　北京　 100029
  2.北京中医药大学东方医院
  3.浙江省中医院
  4.首都医科大学附属北京胸科医院
- 作者简介：
  
  范钰晗，女，在读硕士生
  # 史利卿，男，博士，主任医师、教授，博士生导师，E-mail：shiliqing3662@sina.com
- 基金信息：
  
  国家自然科学基金资助项目(81373588);北京市自然科学基金项目(7192115;7184224);北京中医药大学科研基金项目(2018-JYBZZ-JS144;2017-JYB-JS-102);北京中医药大学东方医院“1166”人才培养项目(040204001001002012)
- DOI：10.3969/j.issn.2095-6606.2021.05.015
  中图分类号： R256.11
- 纸质出版日期：2021-09-30，
  
  收稿日期：2021-05-11，
- 稿件说明：
移动端阅览
范钰晗, 史利卿, 马建岭, 等. 慢性咳嗽寒咳证中医病因病机及物质基础探讨[J]. 现代中医临床, 2021,28(5):65-68.

Yuhan Fan, Liqing Shi, Jianling Ma, et al. Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine[J]. Modern Chinese Clinical Medicine, 2021,28(5):65-68.
范钰晗, 史利卿, 马建岭, 等. 慢性咳嗽寒咳证中医病因病机及物质基础探讨[J]. 现代中医临床, 2021,28(5):65-68. DOI： 10.3969/j.issn.2095-6606.2021.05.015.

Yuhan Fan, Liqing Shi, Jianling Ma, et al. Discussion on the etiology and pathogenesis of chronic cough of the cold pattern in traditional Chinese medicine as well as its material basis in Western medicine[J]. Modern Chinese Clinical Medicine, 2021,28(5):65-68. DOI： 10.3969/j.issn.2095-6606.2021.05.015.

摘要

临床常见寒冷刺激诱发的慢性咳嗽。历代医家强调久咳病因多为瘀、寒、风、虚等，以及内、外寒共同作用导致慢性咳嗽寒咳证。本团队认为寒冷刺激诱发慢性咳嗽寒咳证具有内外合邪、脏腑相关、虚实夹杂的病机特点。瞬时受体电位A1(transient receptor potential ankyrin 1，TRPA1)和瞬时受体电位M8(transient receptor potential melastatin 8，TRPM8)冷感觉通道参与导致机体咳嗽敏感性增高的多个环节，可能是慢性咳嗽寒咳证发病的重要物质基础之一。

Abstract

Chronic cough induced by cold stimulation is common clinically. TCM physicians of all dynasties have emphasized that the etiology of prolonged cough is mostly stasis

cold

wind

deficiency

as well as coordinated work of internal and external colds. Our research team believes that cold cough induced by cold stimulation is characterized by internally and externally combined pathogens

zang

organ relevance

and deficiency-excess complex. Transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential melastatin 8(TRPM8) cold sensory channels are involved in many links leading to the increased cough sensitivity

which may be one of the material bases for the pathogenesis of cold cough of chronic cough.

关键词

寒冷刺激慢性咳嗽寒咳病因病机瞬时受体电位通道

Keywords

cold stimulationchronic coughcold coughetiology and pathogenesistransient receptor potential channel

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