徐荣谦教授治疗多发性抽动症的组方规律与疗效评价研究

严雪儿; 李杰; 吴凤芝; 贾鹰珏; 陈光耀; 郑思思; 刘燕; 周芹; 葛肖波; 李峰; 宋月晗

doi:10.3969/j.issn.2095-6606.2021.06.009

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徐荣谦教授治疗多发性抽动症的组方规律与疗效评价研究

名老中医经验 | 更新时间：2021-12-06

- 徐荣谦教授治疗多发性抽动症的组方规律与疗效评价研究
- Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome
- 现代中医临床 2021年28卷第6期页码：41-45
- 作者机构：
  
  1.北京中医药大学　北京　100029
  2.中国中医科学院望京医院
  3.首都医科大学附属北京安定医院
- 作者简介：
  
  严雪儿，女，在读本科生
  #宋月晗，女，博士，教授，硕士生导师，E-mail: songyuehan1981@126.com
- 基金信息：
  
  国家自然科学基金面上项目(81874427);北京中医药科技发展资金项目(JJ2016-81)
- DOI：10.3969/j.issn.2095-6606.2021.06.009
  中图分类号： R272.6
- 纸质出版日期：2021-11-30，
  
  收稿日期：2021-03-21，
- 稿件说明：
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严雪儿, 李杰, 吴凤芝, 等. 徐荣谦教授治疗多发性抽动症的组方规律与疗效评价研究[J]. 现代中医临床, 2021,28(6):41-45.

Xue’er Yan, Jie Li, Fengzhi Wu, et al. Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome[J]. Modern Chinese Clinical Medicine, 2021,28(6):41-45.
严雪儿, 李杰, 吴凤芝, 等. 徐荣谦教授治疗多发性抽动症的组方规律与疗效评价研究[J]. 现代中医临床, 2021,28(6):41-45. DOI： 10.3969/j.issn.2095-6606.2021.06.009.

Xue’er Yan, Jie Li, Fengzhi Wu, et al. Prof. Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome[J]. Modern Chinese Clinical Medicine, 2021,28(6):41-45. DOI： 10.3969/j.issn.2095-6606.2021.06.009.

摘要

目的

基于数据挖掘探讨徐荣谦教授治疗多发性抽动症的组方规律，以及以温胆汤为主方的疗效评价研究。

方法

纳入东直门医院符合多发性抽动症诊断标准的首诊病例157例，基于关联规则分析用药规律。纳入30例符合《精神疾病诊断与统计手册》(DSM-IV-TR)的多发性抽动症患者，经徐荣谦教授辨证后开具以温胆汤为基础方的方药，收集并对比治疗前后患者的耶鲁综合抽动严重程度量表(yale global tic severityb scale

YGTSS)评分。

结果

对157例患者选用方药关联结果进行分析，置信度及支持度较高的配伍主要集中在温胆汤的药物，多配合使用镇肝息风药物石决明、生龙齿、钩藤以及养心安神药物炒酸枣仁、蕤仁。30例患者治疗后YGTSS总分及各子项包括次数、频率、强度、复杂性、干扰、缺损的得分均低于治疗前，差异具有统计学意义（

0.05）。

结论

以温胆汤为基础方治疗多发性抽动症具有较好的临床疗效。

Abstract

Objective

To explore Prof. Xu Rongqian’s prescription rules in the treatment of Tourette Syndrome(TS)based on data mining and to explore the curative effect evaluation study of

Wendan

Decoction as the main prescription.

Methods

One hundred and fifty-seven first-diagnosed cases that met the diagnostic criteria were included

and Professor Xu’s medication rules were explored based on association rules. Thirty patients diagnosed as having TS by using Diagnostic and Statistical Manual of Mental Disorders(DSM-IV-TR) were treated with herb formulas based on Professor Xu Rongqian’s application of modified

Wendan

Decoction.The scores of The Yale Global Tic Severity Scale(YGTSS) before and after treatment were observed.

Results

The association of prescriptions and medicines selected by 157patients was analyzed

The compatibility with higher confidence and support was mainly concentrated on the medicines of

Wendan

Decoction

and the combined use of the live-calming and wind-relieving medicinals

for example

shijueming

(Concha Haliotidis)

sheng longchi

( raw Dens Draconis)

gouteng

(Ramulus Uncariae Cum Uncis)andmind-tranquilizing medicinals such as

chao suanzaoren

(fried Semen Ziziphi Spinosae) and

ruiren

(Nux Prinsepiae).The total score and six dimensions including number

frequency

intensity

complexity

interference and damage scores of YGTSS were all significantly lower after treatment than before treatment(

0.05).

Conclusions

Professor Xu’s application of modified

Wendan

Decoction as basic herb formulas has a good effect in the treatment of Tourette Syndrome.

关键词

徐荣谦多发性抽动症温胆汤耶鲁综合抽动严重程度量表关联分析

Keywords

Xu RongqianTourette SyndromeWendan Decoctionthe Yale Global Tic Severity Scaleassociation rules

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