调更益经方改善IVF-ET肾虚血瘀证卵巢低反应患者子宫内膜容受性的临床观察*
Tiaogeng Yijing Formula promotes the receptivity of endometrium in poor ovarian response patients with kidney deficiency and blood stasis syndrome undergoingin vitro fertilization-embryo transfer*- 现代中医临床 2022年29卷第1期 页码：5-10
- 作者机构：
1.青岛市中医医院(市海慈医院)妇一科 青岛 266000
2.青岛市中医医院(市海慈医院)临床药学科
- 作者简介：
薛辉，女，博士，副主任医师
#闫倩，女，主管护士，E-mail：94197244@qq.com
- 基金信息：山东省中医药科技发展计划项目(2019－0595)
DOI：10.3969/j.issn.2095-6606.2022.01.002
中图分类号： R271.9纸质出版日期：2022-01-30，
收稿日期：2021-01-04，
- 稿件说明：
移动端阅览
薛辉, 曲正, 任秀英, 等. 调更益经方改善IVF-ET肾虚血瘀证卵巢低反应患者子宫内膜容受性的临床观察*[J]. 现代中医临床, 2022,29(1):5-10.
Hui XUE, Zheng QU, Xiuying REN, et al.
Tiaogeng Yijing Formula promotes the receptivity of endometrium in poor ovarian response patients with kidney deficiency and blood stasis syndrome undergoingin vitro fertilization-embryo transfer*[J]. Modern Chinese Clinical Medicine, 2022,29(1):5-10.薛辉, 曲正, 任秀英, 等. 调更益经方改善IVF-ET肾虚血瘀证卵巢低反应患者子宫内膜容受性的临床观察*[J]. 现代中医临床, 2022,29(1):5-10. DOI： 10.3969/j.issn.2095-6606.2022.01.002.
Hui XUE, Zheng QU, Xiuying REN, et al.
Tiaogeng Yijing Formula promotes the receptivity of endometrium in poor ovarian response patients with kidney deficiency and blood stasis syndrome undergoingin vitro fertilization-embryo transfer*[J]. Modern Chinese Clinical Medicine, 2022,29(1):5-10. DOI： 10.3969/j.issn.2095-6606.2022.01.002.
摘要
目的
2
观察调更益经方对体外受精—胚胎移植技术(IVF-ET)中肾虚血瘀证卵巢低反应(POR)患者子宫内膜容受性和妊娠结局的影响。
方法
2
将42例POR患者随机分为治疗组21例、对照组21例，剔除脱落病例后，治疗组20例、对照组20例。治疗组自月经第7 d予口服调更益经方。连续治疗14 d，调理3个月经周期，进入下次微刺激促排卵周期。对照组无任何治疗，直接进入微刺激促排卵周期。观察种植窗子宫内膜相对灰度值，子宫内膜厚度、内膜形态、血流指数，胚胎种植率、临床妊娠率。
结果
2
治疗组治疗后子宫内膜整合素αvβ3，转化生长因子(TGF-β10)，血管内皮生长因子(VEGF)蛋白表达高于对照组，差异均有统计学意义(
P
<
0.05)。治疗组治疗后A型子宫内膜比例、子宫内膜血流阻力指数(RI)和搏动指数(PI)，与对照组比较，差异均有统计学意义(
P
<
0.05)。治疗组治疗后临床妊娠率与对照组比较，差异有统计学意义(
P
<
0.05)，治疗组妊娠率高于对照组。
结论
2
调更益经方可改善POR患者的子宫内膜容受性，提高种植窗期子宫内膜整合素αvβ3，TGF-β1，VEGF蛋白的表达，改善POR患者子宫内膜形态，降低子宫内膜RI和PI，从而提高临床妊娠率。
Abstract
Objective
2
To observe the effect of
Tiaogeng Yijing
Formula on the receptivity of endometrium and pregnancy outcomes of the poor ovarian response (POR) patients with kidney deficiency and blood stasis syndrome during
in vitro
fertilization and embryo transfer (IVF-ET).
Methods
2
A total of 42 POR patients were randomly and equally assigned to the treatment group (21 cases) and control group (21 cases). After the withdrawals excluded
there were 20 left both in the treatment group and the control group. Patients in the treatment group received
Tiaogeng Yijing
Formula for 14 days of 3 consecutive menstrual cycles in addition to microstimulation from the seventh day of menstruation
while patients in the control group received no treatment for three months before undergoing microstimulation. Western blotting was used to determine integrin αvβ3
transforming growth factor-β (TGF-β1)
LIF
granulocyte colony stimulating factor (G-CSF)
vascular endothelial growth factor (VEGF)in the two groups during planting window phase of endometrium. Endometrial thickness
proportion of type A endometrium
blood flow index
planting rate and pregnancy rate were compared between the two groups.
Results
2
Endometrium relative grey value of planting window phase
integrin αvβ3
TGF-β1 and VEGF protein expression were significantly higher in the treatment group than in the control group (
P
<
0.05). Proportion of type A endometrium
endometrial resistance index and pulsatility index were significantly higher in the treatment group than in the control group (
P
<
0.05). There was a significant difference in clinical pregnancy rate between two groups (
P
<
0.05).
Conclusions
2
Tiaogeng Yijing
Formula can improve the receptivity of endometrium
upr-regulate the expressions of integrin αvβ3
TGF-β1 and VEGF protein in planting window phase of endometrium
improve the type of endometrium and decrease the blood flow index to increase embryo implantation and pregnancy rate.
关键词
调更益经方IVF-ET卵巢低反应子宫内膜容受性
Keywords
Tiaogeng Yijing Formulain vitro fertilization and embryo transferpoor ovarian responsereceptivity of endometrium
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