1.北京中医药大学 北京 100029
2.北京中医药大学东方医院
乔晓叶,女,在读硕士生
# 楼姣英,女,博士,主任医师,硕士生导师,E-mail:doctorlou@126.com
纸质出版日期:2022-05-30,
收稿日期:2022-01-07,
移动端阅览
乔晓叶, 楼姣英. 中医体质与宫颈高危型人乳头瘤病毒感染相关的Logistic回归分析[J]. 现代中医临床, 2022,29(3):1-6.
Xiaoye QIAO, Jiaoying LOU. Logistic regression analysis of the correlation between TCM body constitutions and cervical HR-HPV infection[J]. Modern Chinese Clinical Medicine, 2022,29(3):1-6.
乔晓叶, 楼姣英. 中医体质与宫颈高危型人乳头瘤病毒感染相关的Logistic回归分析[J]. 现代中医临床, 2022,29(3):1-6. DOI: 10.3969/j.issn.2095-6606.2022.03.001.
Xiaoye QIAO, Jiaoying LOU. Logistic regression analysis of the correlation between TCM body constitutions and cervical HR-HPV infection[J]. Modern Chinese Clinical Medicine, 2022,29(3):1-6. DOI: 10.3969/j.issn.2095-6606.2022.03.001.
目的
2
分析中医体质与宫颈高危型人乳头瘤病毒(HR-HPV)感染的相关性。
方法
2
将203例行HR-HPV筛查的患者,按是否HR-HPV感染分为HR-HPV感染阴性组103例、HR-HPV感染阳性组100例。收集2组患者年龄、体重指数、学历、婚姻状况等基本信息。采用单因素Logistic回归分析确定与HR-HPV感染相关的因素,将单因素Logistic分析中
P
<
0.05的变量纳入多因素Logistic回归分析,确定与HR-HPV感染相关的独立危险因素。
结果
2
年龄、学历、婚姻状况、一周内抽烟超过10支、避孕套的使用、怀孕次数、人工流产次数、性伴侣数、初次性生活年龄、中医体质分布指标在2组间差异有统计学意义(
P
<
0.05)。年龄、一周吸烟超过10支、怀孕次数、人工流产次数、性伴侣数、中医体质中的阳虚质、痰湿质、血瘀质、特禀质、气郁质与是否HR-HPV感染呈正相关(
P
<
0.05);学历、一周饮酒超过50 mL、未婚与是否HR-HPV感染呈负相关(
P
<
0.05)。多因素Logistic回归分析显示,与平和质相比,痰湿质、血瘀质和特禀质是HR-HPV感染的独立危险因素。
结论
2
中医体质与HR-HPV感染的发生存在相关性。
Objective
2
The purpose of this study was to analyze the correlation between TCM constitutions and cervical high-risk human papillomavirus (HR-HPV) infection.
Methods
2
203 patients who were routinely screened for HR-HPV were divided into the HR-HPV infection negative group (103 patients) and the HR-HPV infection positive group (100 patients) based on whether they were infected by the virus or not. Basic information such as age
body mass index
education
and marital status were collected from the 2 groups of patients. Univariate logistic regression was used to identify the factors associated with HR-HPV infection. Those with
P
<
0.05 were included in the multivariate logistic regression to determine the independent risk factors associated with HR-HPV infection.
Results
2
Age
education
marital status
smoking more than 10 cigarettes in a week
condom use
number of pregnancies
number of abortions
number of sexual partners
age of first sexual intercourse
and TCM constitution distribution indexes were the factors that showed statistically significant differences between the 2 groups (
P
<
0.05). Age
smoking more than 10 cigarettes a week
number of pregnancies
number of abortions
number of sexual partners
yang-deficiency type
phlegm-dampness type
blood-stasis type
inherited-special type
and qi-stagnation type of TCM body constitutions were positively correlated with the presence of HR-HPV infection (
P
<
0.05). Education
drinking more than 50 mL of alcohol in a week
and being unmarried were negatively correlated with whether HR-HPV infection was present (
P
<
0.05). The multivariate logistic regression analysis showed that the constitutions of the phlegm-dampness
blood-stasis and inherited-special types were independent risk factors for HR-HPV infection compared with the balance constitution.
Conclusions
2
There is a correlation between TCM constitutions and the occurrence of HR-HPV infection.
高危型人乳头瘤病毒中医体质Logistic回归
high-risk human papillomavirustraditional Chinese medicine constitutionlogistic regression
HU Z, MA D.The precision prevention and therapy of HPV-related cervical cancer: new concepts and clinical implications[J].Cancer Med,2018, 7(10):5217-5236.
OU Y C,FU H C,TSENG C W,et al.The influence of probiotics on genital high-risk human papilloma virus clearance and quality of cervical smear:a randomized placebo-controlled trial[J/OL].BMC Womens Health,2019,19(1):103[2021-12-02]. https://doi.org/10.1186/s12905-019-0798-yhttps://doi.org/10.1186/s12905-019-0798-y.
FORMAN D,DE M C,LACEY C J,et al. Global burden of human papillomavirus and related diseases[J/OL].Vaccine,2012,30(Suppl 5):F12-F23[2021-12-02].https://doi.org/10.1016/j.vaccine.2012.07.055https://doi.org/10.1016/j.vaccine.2012.07.055.
WOODMAN C B, COLLINS S I, YOUNG L S. The natural history of cervical HPV infection: unresolved issues[J].Nat Rev Cancer,2007, 7(1):11-22.
Centers for Disease Control and Prevention(CDC).Human papillomavirus-associated cancers - United States, 2004-2008[J].MMWR Morb Mortal Wkly Rep,2012, 6(1):258-261.
MITRA A,MACINTYRE D A,MARCHESI J R,et al.The vaginal microbiota,human papillomavirus infection and cervical intraepithelial neoplasia:what do we know and where are we going next?[J/OL].Microbiome,2016,4:58[2021-12-02]. https://doi.org/10.1186/s40168-016-0203-0https://doi.org/10.1186/s40168-016-0203-0.
王琦.中医体质学在大健康问题中的应对与优势[J].北京中医药大学学报,2021, 44(3):197-202.
薛凤霞,刘宏图,刘朝晖.女性下生殖道人乳头瘤病毒感染诊治专家共识[J].中国实用妇科与产科杂志,2015, 31(10):894-897.
谢幸,苟文丽.妇产科学[M].北京:人民卫生出版社,2013:402.
中华中医药学会.中医体质分类与判定(ZYYXH/T157-2009)[J].世界中西医结合杂志,2009, 4(4):303-304.
王琦.中医体质学[M].北京:中国医药科技出版社,1995:1.
刘君,薛晓鸥,马秀丽,等.高危型人乳头瘤病毒感染宫颈病变患者体质特点探析[J].中国中医药信息杂志,2020, 27(1):14-18.
张玉珍.中医妇科学[M].北京:中国中医药出版社,2002:182.
白若冰,严泽,白启明.HPV感染相关的慢性宫颈炎患者中医体质分布特点分析[J].慢性病学杂志,2015, 16(5):505-507.
李娅.宫颈高危型HPV感染患者的中医体质、证素分析及中药治疗的文献研究[D].北京:北京中医药大学,2018.
王琳.高危型人乳头瘤病毒感染与中医体质的相关性研究[D].北京:北京中医药大学,2015.
刘静.宫颈HR-HPV感染与中医体质及阴道免疫微环境的关系[D].北京:北京中医药大学,2012.
张蔚苓,赵珊琼.高危型人乳头瘤病毒感染与中医体质的相关性研究[J].中国中医药科技,2019, 26(4):486-490.
田新.宫颈HR-HPV感染患者的中医体质和心理状态的相关性研究[D].哈尔滨:黑龙江中医药大学,2019.
张杜娟.宫颈人乳头瘤病毒(HPV)感染与阴道微生态失调及中医体质分布的相关性研究[D].天津:天津中医药大学,2020.
韩琴玉.宫颈HPV感染患者的中医体质分析及温针灸治疗阳虚质HR-HPV感染的疗效观察[D].天津:天津中医药大学,2021.
傅山.傅青主女科[M].上海:上海人民出版社,1978:1.
马士才,马亚会,王道义,等.治肝理论在《傅青主女科》带下篇中的应用[J].湖北中医杂志,2020, 42(6):47-49.
薛已.女科撮要[M].北京:中国中医药出版社,2015:15.
程文秀,郁悦,刁翰林,等.中医体质学说在子宫腺肌病防治方面的应用研究[J].现代中医临床,2021, 28(1):69-72.
邢天野,林贺,尚晓玲,等.血瘀体质与冠心病、妇科疾病的关系研究[J].吉林中医药,2020, 40(6):735-737.
王济,李英帅,李玲孺,等.国医大师王琦论中医未病学理论体系构建[J].现代中医临床,2017, 24(3):5-8.
0
浏览量
199
下载量
0
CSCD
关联资源
相关文章
相关作者
相关机构