肠道菌群与艾滋病关系及健脾运脾对其的影响

刘亚楠; 王丹妮; 李鹏宇; 陈莉华; 郭会军

doi:10.3969/j.issn.2095-6606.2022.03.008

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肠道菌群与艾滋病关系及健脾运脾对其的影响

思路与方法 | 更新时间：2022-06-02

- 肠道菌群与艾滋病关系及健脾运脾对其的影响
- The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen
- 现代中医临床 2022年29卷第3期页码：34-38
- 作者机构：
  
  1.河南中医药大学　郑州　450046
  2.河南中医药大学第一附属医院
  3.河南省中医药防治艾滋病临床研究中心
- 作者简介：
  
  刘亚楠，女，在读博士生
  # 郭会军，男，主任医师，博士生导师，E-mail：guo.6268505@163.com
- 基金信息：
  
  河南省中医药科学研究专项课题(2022ZY1042);河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020031);中原英才计划(ZYYCYU202012119);国家自然科学基金资助项目(82004207);河南省重点研发与推广专项(202102310178)
- DOI：10.3969/j.issn.2095-6606.2022.03.008
  中图分类号： R259
- 纸质出版日期：2022-05-30，
  
  收稿日期：2021-02-18，
- 稿件说明：
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刘亚楠, 王丹妮, 李鹏宇, 等. 肠道菌群与艾滋病关系及健脾运脾对其的影响[J]. 现代中医临床, 2022,29(3):34-38.

Yanan LIU, Danni WANG, Pengyu LI, et al. The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen[J]. Modern Chinese Clinical Medicine, 2022,29(3):34-38.
刘亚楠, 王丹妮, 李鹏宇, 等. 肠道菌群与艾滋病关系及健脾运脾对其的影响[J]. 现代中医临床, 2022,29(3):34-38. DOI： 10.3969/j.issn.2095-6606.2022.03.008.

Yanan LIU, Danni WANG, Pengyu LI, et al. The relationship between intestinal flora and AIDS and the role of fortifying and activating the spleen[J]. Modern Chinese Clinical Medicine, 2022,29(3):34-38. DOI： 10.3969/j.issn.2095-6606.2022.03.008.

摘要

艾滋病(AIDS)因其具有高度传染性和不可治愈性，是目前严重威胁全球公众健康的重要疾病之一。人类免疫缺陷病毒(HIV)侵入人体后首先攻击人体内的

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T淋巴细胞，肠道是淋巴组织最丰富的场所，因此，HIV会在肠道内聚集，破坏

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T淋巴细胞，致使患者肠道菌群失衡，引发一系列机会性感染和相关性疾病。HIV感染初期，

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T淋巴细胞在肠道内快速大量减少，

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T淋巴细胞比例下降，造成肠道黏膜免疫紊乱。HIV感染无症状期，慢性免疫激活是其独有特点。一些重要部位的

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T淋巴细胞数量稳定和肠道菌群的平衡可能是影响AIDS患者病情进展的重要因素。脾主运化有助于肠道菌群的恢复并助其发挥代谢吸收功能。中医药可有效调节AIDS患者的肠道菌群结构和机体的免疫重建状态。

Abstract

Acquired immunodeficiency syndrome (AIDS) is one of the major diseases that seriously threaten global public health due to its high infectivity and incurability. After entering the human body

HIV first attacks the

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T lymphocytes. Since the gut-associated lymphoid tissue (GALT) is the largest mass of lymphoid tissue in the body

HIV tends to accumulate in the intestinal tract and destroy

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T lymphocytes there

resulting in the dysbiosis of intestinal flora of the patient

leading to a series of opportunistic infections and related diseases. In the early stage of HIV infection

the number of

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T cells in the intestine decreases rapidly and massively

and the CD4/CD8 ratio decreases as well

causing immune disorders of the intestinal mucosa. The asymptomatic stage of HIV infection is characterized by chronic immune activation. The stable number of

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T lymphocytes in some important parts of the body and the balance of intestinal flora may be important factors affecting the progression of the disease. The spleen

which governs transportation and transformation

can play a crucial role in the recovery of the damaged intestinal flora and its function in host nutrient metabolism. By fortifying and activating the spleen

Traditional Chinese Medicine (TCM) can effectively regulate the intestinal flora and facilitate the immune reconstitution of AIDS patients.

关键词

艾滋病中医药肠道菌群肠道黏膜免疫功能

Keywords

AIDStraditional Chinese medicineintestinal floraintestinal mucosaimmune function

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