调肝养血方加味口服联合耳穴压丸治疗乳腺癌相关抑郁状态临床研究
Evaluation of the clinical efficacy of
Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression- 现代中医临床 2022年29卷第4期 页码：1-7
- 作者机构：
1.北京中医药大学第一临床医学院 北京 100700
2.北京同仁堂中医医院
3.河北省张家口市万全区中医院
- 作者简介：
黄建祎，女，住院医师
# 储真真，女，博士，教授、主任医师，硕士生导师，E-mail：chuen111@sina.com
- 基金信息：中央高校基本科研业务费专项资金资助(2019－JYB-XS－173)
DOI：10.3969/j.issn.2095-6606.2022.04.001
中图分类号： R273纸质出版日期：2022-07-30，
收稿日期：2021-12-30，
- 稿件说明：
移动端阅览
黄建祎, 储真真, 温婷惠, 等. 调肝养血方加味口服联合耳穴压丸治疗乳腺癌相关抑郁状态临床研究[J]. 现代中医临床, 2022,29(4):1-7.
Jianyi HUANG, Zhenzhen CHU, Tinghui WEN, et al. Evaluation of the clinical efficacy of
Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression[J]. Modern Chinese Clinical Medicine, 2022,29(4):1-7.黄建祎, 储真真, 温婷惠, 等. 调肝养血方加味口服联合耳穴压丸治疗乳腺癌相关抑郁状态临床研究[J]. 现代中医临床, 2022,29(4):1-7. DOI： 10.3969/j.issn.2095-6606.2022.04.001.
Jianyi HUANG, Zhenzhen CHU, Tinghui WEN, et al. Evaluation of the clinical efficacy of
Tiaogan Yangxue Jiawei Formula and acupressure ear beads for breast cancer related depression[J]. Modern Chinese Clinical Medicine, 2022,29(4):1-7. DOI： 10.3969/j.issn.2095-6606.2022.04.001.
摘要
目的
2
观察调肝养血方加味口服联合耳穴压丸治疗乳腺癌相关抑郁状态的临床疗效。
方法
2
将70例乳腺癌伴抑郁状态的患者随机分为治疗组35例、对照组35例，剔除脱落病例后治疗组32例、对照组31例。对照组采用乳腺癌常规标准化治疗，针对患者抑郁情绪进行心理疏导及健康宣教。治疗组在对照组的基础上加用调肝养血方加味口服配合耳穴压丸治疗。观察汉密尔顿抑郁量表(HAMD)评分、匹兹堡睡眠质量指数量表(PSQI)评分、中医证候积分、中医证候疗效、性激素水平，并进行安全性评价。
结果
2
HAMD评分治疗组治疗后较本组治疗前降低(
P
<
0.05)，对照组治疗后与本组治疗前比较，差异无统计学意义(
P
>
0.05)。治疗前2组比较差异无统计学意义(
P
>
0.05)，治疗后治疗组较对照组降低明显，2组治疗前后差值比较，差异有统计学意义(
P
<
0.05)，治疗组优于对照组。PSQI评分治疗组治疗后较本组治疗前降低(
P
<
0.05)，对照组治疗后与本组治疗前比较，差异无统计学意义(
P
>
0.05)。治疗前2组比较差异无统计学意义(
P
>
0.05)，治疗后治疗组较对照组降低明显，2组治疗前后差值比较，差异有统计学意义(
P
<
0.05)，治疗组优于对照组。中医证候积分治疗组治疗后较本组治疗前降低(
P
<
0.05)，对照组治疗后与本组治疗前比较，差异无统计学意义(
P
>
0.05)。治疗前2组比较差异无统计学意义(
P
>
0.05)，治疗后治疗组较对照组降低明显，2组治疗前后差值比较，差异有统计学意义(
P
<
0.05)，治疗组优于对照组。2组均无治愈病例，治疗组32例中，显效12例，有效18例，无效2例，总有效率为93.75%；对照组31例中，显效3例，有效15例，无效13例，总有效率为58.06%。经秩和检验，
Z
＝－3.623，
P
<
0.05，说明治疗组疗效优于对照组。雌二醇(E
2
)、促卵泡生成素(FSH)及促黄体生成素(LH)水平2组治疗后与本组治疗前比较差异均无统计学意义(
P
>
0.05)。2组治疗前后差值比较，差异均无统计学意义(
P
>
0.05)。
结论
2
在西医常规治疗的基础上，调肝养血方加味口服联合耳穴压丸治疗乳腺癌相关抑郁状态具有较好的疗效。
Abstract
Objective
2
To evaluate the clinical efficacy of
Tiaogan Yangxue Jiawei
Formula and acupressure ear beads in patients with breast cancer related depression.
Methods
2
A total of 70 breast cancer patients with depression were randomly assigned to the control group and treatment group
with 35 cases in each group. After the drops-out and withdrawals excluded
there were 32 cases in the treatment group and 31 cases in the control group. The control group received conventional standardized treatment of breast cancer
and psychological counseling and health education for depression. On the basis of the control group
the treatment group received additional
Tiaogan Yangxue Jiawei
Formula and acupressure ear beads. Efficacy was assessed by using the Hamilton Depression Scale (HAMD)
Pittsburgh Sleep Scale (PSQI)
TCM syndrome score
sex hormone levels (estradiol
follicle stimulating hormone and luteinizing hormone) and safety indexes.
Results
2
The HAMD score in the treatment group was lower after treatment than before treatment (
P
<
0.05)
but there was no significant before-after difference in the control group (
P
>
0.05). Before treatment
there was no significant difference in HAMD score between the control group and treatment group (
P
>
0.05). After treatment
the HAMD score was significantly lower in the treatment group than in the control group. The before-after treatment difference between the two groups was statistically significant (
P
<
0.05)
greater in the treatment group than in the control group.The PSQI score in the treatment group was lower than that before treatment (
P
<
0.05)
but there was no significant before-after difference in the control group (
P
>
0.05). There was no significant difference between the control group and that before treatment (
P
>
0.05). After treatment
the PSQI score was significantly lower in the treatment group than in the control group. There was a significant difference between the two groups before and after treatment (
P
<
0.05)
greater in the treatment group than in the control group.The score of TCM syndrome in the treatment group was lower than that before treatment (
P
<
0.05)
but there was no significant before-after difference in the control group (
P
>
0.05). There was no significant difference between the two groups before treatment (
P
>
0.05). After treatment
the TCM syndrome score was significantly lower in the treatment group than in the control group. The difference between the two groups before and after treatment was statistically significant (
P
<
0.05)
greater in the treatment group than in the control group.There were no cured cases in the two groups. Among the 32 cases in the treatment group
12 cases were significantly effective
18 cases were effective and 2 cases were ineffective. The total effective rate was 93.75%; In the control group
3 cases were markedly effective
15 cases were effective and 13 cases were ineffective. The total effective rate was 58.06%. By rank sum test
Z
= -3.623
(
P
<
0.05)
it indicated that the curative effect was better in the treatment group than in the control group.There was no significant difference in the levels of estradiol (E
2
)
follicle stimulating hormone (FSH) and luteinizing hormone (LH) between the two groups after treatment and before treatment (
P
>
0.05). There was no significant difference between the two groups before and after treatment (
P
>
0.05).
Conclusions
2
On the basis of modern medical routine treatment
the
Tiaogan Yangxue Jiawei
Formula and acupressure ear beads have a better curative effect in treating breast cancer related depression.
关键词
乳腺癌抑郁状态中医耳穴调肝养血方加味
Keywords
breast cancerdepressionChinese traditional medicineauricular acupointsTiaogan Yangxue Jiawei Formula
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