益气活血方联合肝素钠注射液治疗急性下肢深静脉血栓临床观察
Clinical efficacy of
Yiqi Huoxue Formula with heparin sodium injection for acute deep venous thrombosis of lower extremities- 现代中医临床 2022年29卷第4期 页码：17-22
- 作者机构：
河北省沧州中西医结合医院 沧州 061001
- 作者简介：
杨静，男，在读博士生，主治医师
# 王植荣，女，主任医师、教授
- 基金信息：河北省中医药管理局科研计划项目(2020495)
DOI：10.3969/j.issn.2095-6606.2022.04.003
中图分类号： R26纸质出版日期：2022-07-30，
收稿日期：2021-03-31，
- 稿件说明：
移动端阅览
杨静, 王峰, 王植荣, 等. 益气活血方联合肝素钠注射液治疗急性下肢深静脉血栓临床观察[J]. 现代中医临床, 2022,29(4):17-22.
Jing YANG, Feng WANG, Zhirong WANG, et al. Clinical efficacy of
Yiqi Huoxue Formula with heparin sodium injection for acute deep venous thrombosis of lower extremities[J]. Modern Chinese Clinical Medicine, 2022,29(4):17-22.杨静, 王峰, 王植荣, 等. 益气活血方联合肝素钠注射液治疗急性下肢深静脉血栓临床观察[J]. 现代中医临床, 2022,29(4):17-22. DOI： 10.3969/j.issn.2095-6606.2022.04.003.
Jing YANG, Feng WANG, Zhirong WANG, et al. Clinical efficacy of
Yiqi Huoxue Formula with heparin sodium injection for acute deep venous thrombosis of lower extremities[J]. Modern Chinese Clinical Medicine, 2022,29(4):17-22. DOI： 10.3969/j.issn.2095-6606.2022.04.003.
摘要
目的
2
观察益气活血方联合肝素钠注射液治疗急性下肢深静脉血栓的临床疗效。
方法
2
将70例急性下肢深静脉血栓气虚血瘀证患者随机分为治疗组35例、治疗组35例，剔除脱落病例后，对照组33例、治疗组33例。对照组给予肝素钠注射液治疗，治疗组在对照组治疗的基础上加用益气活血方治疗。观察临床疗效，皮肤温度、皮肤色泽、疼痛、患肢肿胀、Homans征、超声改变等患肢疗效指标量化评分，D－二聚体(D-D)、纤维蛋白原(FIB)和抗凝血酶Ⅲ(AT-Ⅲ)等凝血指标，超敏C反应蛋白(hs-CRP)、白细胞介素－6(IL-6)、肿瘤坏死因子－a(TNF-α)等炎性指标，并进行安全性评估。
结果
2
治疗组33例中痊愈10例，显效 11 例，有效 10 例，无效 2例，总有效率为 93.94%；对照组33例中，痊愈7例，显效 7 例，有效 9 例，无效 10 例，总有效率为 69.70%。经秩和检验，
Z
＝－2.150，P＝0.032，P
<
0.05，说明治疗组临床疗效优于对照组。2组治疗后皮肤温度、皮肤色泽、疼痛、患肢肿胀、
Homans
征、超声改变评分较本组治疗前均降低(P
<
0.05)。治疗后皮肤温度、皮肤色泽、疼痛、患肢肿胀、
Homans
征、超声改变评分治疗组较对照组均降低明显(P
<
0.05)，治疗组优于对照组。2组治疗后
D
-
D
、
FIB
较本组治疗前均降低，
AT
-Ⅲ较本组治疗前升高，差异均有统计学意义(
P
<
0.05)。治疗后D-D、FIB治疗组较对照组降低明显，AT-Ⅲ治疗组较对照组升高明显，差异均有统计学意义(
P
<
0.05)，治疗组优于对照组。2组治疗后hs-CRP、IL-6、TNF-α较本组治疗前均降低(
P
<
0.05)。治疗后hs-CRP、IL-6、TNF-α治疗组均较对照组降低明显(
P
<
0.05)，治疗组优于对照组。
结论
2
益气活血方联合肝素钠注射液治疗急性下肢深静脉血栓具有较好的临床疗效。
Abstract
Objective
2
To observe the clinical efficacy of
Yiqi Huoxue
Formula combined with heparin sodium injection in the treatment of the acute deep venous thrombosis in the lower limbs.
Methods
2
Seventy patients with acute lower extremity deep venous thrombosis and with the Qi deficiency and blood stasis pattern were randomly assigned to the control group (
n
=35) and treatment group (
n
=35). After the drops-out and withdrawals excluded
there were 33 cases in the control group and 33 cases in the treatment group. The control group was treated with heparin sodium injection
and the treatment group received additional
Yiqi Huoxue
Formula on the basis of the treatment of the control group. Clinical efficacy
skin temperature
skin color
pain
swelling of affected limbs
Homans sign
ultrasonic changes and other quantitative scores of affected limbs
coagulation indexes such as D-Dimer (D-D)
fibrinogen (FIB) and antithrombin Ⅲ (AT-Ⅲ)
high-sensitivity C-reactive protein (hs-CRP)
interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)and other inflammatory indexes were observed
and the safety was assessed.
Results
2
In the treatment group
10 cases were cured
11 cases were markedly effective
10 cases were effective and 2 cases were ineffective. The total effective rate was 93.94%; In the control group
7 cases were cured
7 cases were markedly effective
9 cases were effective and 10 cases were ineffective. The total effective rate was 69.70%. Nonparametric test showed that the clinical effect was better in the treatment group than in the control group (
Z
=-2.150
P
=0.032
P
<
0.05). After treatment
the skin temperature
skin color
pain
swelling of affected limbs
Homans sign and ultrasonic change scores in the two groups were lower than those before treatment (
P
<
0.05). After treatment
the skin temperature
skin color
pain
swelling of affected limbs
Homans sign and ultrasonic change scores in the treatment group were significantly lower than those in the control group (
P
<
0.05). After treatment
D-D and FIB in the two groups were lower than those before treatment
and AT-Ⅲ was higher than those before treatment (
P
<
0.05). After treatment
D-D and FIB were significantly lower in the treatment group than in the control group
and AT-Ⅲ was significantly higher in the treatment group than in the control group (
P
<
0.05)
better in the treatment group than in the control group. After treatment
the hs-CRP
IL-6
TNF-α in the two groups were lower than those before treatment (
P
<
0.05). After treatment
hs-CRP
IL-6
TNF-α were significantly lower in the treatment group than in the control group (
P
<
0.05)
better in the treatment group than in the control group.
Conclusions
2
Yiqi Huoxue
Formula combined with heparin sodium injection has a good clinical effect in the treatment of acute deep venous thrombosis of the lower extremities.
关键词
下肢深静脉血栓抗凝益气活血芪箭消栓通
Keywords
lower limbs’deep venous thrombosisanticoagulant therapyYiqi HuoxueQijian Xiaoshuantong Formula
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