Objective

2

To explore the medication rules of Chinese patent medicine for chronic bronchitis

in the hope of providing referrence for its clinical treatment and new drug development.

Methods

2

Chinese patent medicines for chronic bronchitis prescriptions were collected from

Chinese Pharmacopoeia

. The Traditional Chinese Medicine Inheritance Support System was used to count indications and frequency of traditional Chinese medicine. The rules of TCM compound and association were analyzed by using the method of association rules. Core medicinal combinations and candidate new prescriptions were extracted based on entropy clustering.

Results

2

Eighty kinds of Chinese patent medicines for chronic bronchitis treatment were found in

Chinese Pharmacopoeia

. Among them

14 kinds of Chinese patent medicines had more than 2 dosage forms

totaling 102 kinds

and the dosage form was mainly pills which are 27 kinds. The main functions of Chinese patent medicines of chronic bronchitis are relieving cough

transforming phlgem

relieving panting

and also clearing heat

clearing the lung

dispersing the lung

moistening the lung and downbearing qi.A total of 80 kinds of Chinese patent medicines for the treatment of chronic bronchitis were included

involving 167 medicinals

and the frequency of medicinals reached 882 times

24 medicinals with its frequency ≥ 7. Most frequently used medicinals were

Gancao

(Radix et Rhizoma Glycyrrhizae)

Kuxingren

(Semen Armeniacae Amarum)

Jiegeng

(Radix Platycodonis)

Mahuang

(Herba Ephedrae) and

Chenpi

(Pericarpium Citri Reticulatae). There were 26 medicinal combinations

with its frequency≥10

for instance

Gancao

and

Kuxingren

Gancao

and

Jiegeng

Chenpi

and

Gancao

Mahuang

and

Kuxingren

. Twenty-four medicinals combinations were revealed

with its frequency≥10

for instance

"

Jiegeng

Kuxingren

→

Gancao

" "

Chenpi

Jiegeng

→

Gancao

" . Based on complex system entropy clustering

a group of 8 core drug combinations were obtained. Based on unsupervised entropy hierarchical clustering

4 new prescriptions for treatment of chronic bronchitis were obtained.

Conclusions

2

The common treatment for chronic bronchitis is to treat both the symptoms and the root causes. Treating the symptoms include relieving cough

transforming phlegm and relieving panting while treating the root causes include coordinating viscera and bowels and regulating Qi. The TCM treatment of chronic bronchitis is flexible

based on clinical syndrome differentiation.