1.北京中医药大学东直门医院 北京 100700
2.北京中医药大学中医脑病研究院
3.中国中医科学院针灸研究所
4.世界中医药学会联合会临床循证研究指导中心
董兴鲁,男,在读博士生
#周莉,女,博士,主任医师,硕士生导师,E-mail:zhouljk7211@163.com
纸质出版日期:2023-01-30,
收稿日期:2022-03-22,
移动端阅览
董兴鲁, 高颖, 唐璐, 等. 基于多元Logistic回归的缺血性中风病恢复期肾虚证证候诊断模型研究[J]. 现代中医临床, 2023,30(1):26-30.
DONG Xinglu, GAO Ying, TANG Lu, et al. A multivariate logistic regression analysis of the diagnosis model of kidney deficiency syndrome in recovery period of ischemic stroke[J]. Modern Chinese Clinical Medicine, 2023,30(1):26-30.
董兴鲁, 高颖, 唐璐, 等. 基于多元Logistic回归的缺血性中风病恢复期肾虚证证候诊断模型研究[J]. 现代中医临床, 2023,30(1):26-30. DOI: 10.3969/j.issn.2095-6606.2023.01.007.
DONG Xinglu, GAO Ying, TANG Lu, et al. A multivariate logistic regression analysis of the diagnosis model of kidney deficiency syndrome in recovery period of ischemic stroke[J]. Modern Chinese Clinical Medicine, 2023,30(1):26-30. DOI: 10.3969/j.issn.2095-6606.2023.01.007.
目的
2
基于多元Logistic回归方法建立缺血性中风病恢复期肾虚证证候诊断模型。
方法
2
通过前瞻性、多中心、动态采集的四诊信息调查,分别在15个分中心纳入符合纳入和排除标准的缺血性中风恢复期患者181例,共得到完整采集的数据信息970例次。利用多元Logistic回归构建肾虚证诊断模型,并通过ROC曲线进行效能判别。
结果
2
筛选出颧红、腰酸、小便频、健忘、脉弱、潮热、膝软、五心烦热、精神萎靡、腰冷、小便清长、脉沉细等12个因素,是缺血性中风恢复期肾虚证成立的相关因素,并构建诊断模型:P=1/[1+Exp(11.223-2.002×颧红-1.861×腰酸-1.738×小便频-1.494×健忘-1.469×脉弱-1.361×潮热-1.297×膝软-1.181×五心烦热-1.028×精神萎靡-0.742×腰冷-0.722×小便清长-0.594×脉沉细)],预测函数模型ROC曲线下面积为0.946,尤登指数为0.766,该诊断模型敏感度为90.5%,特异度为85.4%,同样本的验证诊断一致度为84.1%。
结论
2
通过多元Logistic回归分析,构建基于四诊信息的缺血性中风恢复期肾虚证诊断模型,为缺血性中风恢复期肾虚证辨识提供参考工具。
Objective
2
To establish the diagnosis model of kidney deficiency syndrome in the convalescent period of ischemic stroke based on multivariate logistic regression.
Methods
2
For a prospective
multi-center
dynamic collection of the four-examination information
181 patients with ischemic stroke in the recovery period who met the inclusion criteria were recruited in 15 centers
and a total of 970 complete data sets were obtained. The diagnostic model of kidney deficiency syndrome was constructed by multiple logistic regression
and the efficacy was evaluated by ROC curve.
Results
2
Twelve factors
including hectic cheek
soreness of waist
frequent urination
amnesia
weak pulse
hot flushes
knee weakness
vexing heat in the five centers (chest
palms and soles)
mental fatigue
cold waist
clear abundant urine
and deep and thready pulse
were screened out as the relevant factors for the establishment of kidney deficiency syndrome in the recovery period of ischemic stroke
and a diagnostic model was established: P = 1 / [1+ Exp (11.223-2.002×hectic cheek -1.861×soreness of waist-1.738×frequency of urination-1.494×amnesia-1.469×weak pulse -1.361×hot flushes-1.297×knee weakness-1.181×vexing heat in the five centers -1.028×mental fatigue -0.742× cold waist-0.722×clear abundant urine -0.594×deep and thready pulse)]. The area under the ROC curve in the predictive function model was 0.946
the Youden index was 0.766
the sensitivity was 90.5%
the specificity was 85.4%
and the diagnostic consistency of the same sample was 84.1%.
Conclusion
2
Through the multivariate logistic regression analysis
a diagnosis model of kidney deficiency syndrome in the recovery period of ischemic stroke was constructed based on the information of the four examinations
providing a tool for the condition.
缺血性中风恢复期肾虚证多元Logistic回归ROC曲线诊断量表
recovery period of ischemic strokekidney deficiency syndromemultivariate logistic regressionROC curvediagnostic scale
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