多囊卵巢综合征证候特征与超声下卵巢形态学及血流动力学参数的相关性研究

张雅冬; 许昕

doi:10.3969/j.issn.2095-6606.2023.02.008

您当前的位置：

首页 >

文章列表页 >

多囊卵巢综合征证候特征与超声下卵巢形态学及血流动力学参数的相关性研究

临床研究 | 更新时间：2023-03-31

- 多囊卵巢综合征证候特征与超声下卵巢形态学及血流动力学参数的相关性研究
- Correlation between pattern features of polycystic ovary syndrome and ovarian morphological and hemodynamic parameters under ultrasonography
- 现代中医临床 2023年30卷第2期页码：37-43
- 作者机构：
  
  首都医科大学附属北京中医医院　北京　100010
- 作者简介：
  
  张雅冬，女，硕士，副主任医师
  #许昕，女，硕士，教授、主任医师，博士生导师，E-mail：xuxin@bjzhongyi.com
- 基金信息：
  
  国家自然科学基金资助项目(81674010);国家中医药管理局全国名老中医药专家传承工作室建设项目;北京市属医院科研培育项目(PZ2023018)
- DOI：10.3969/j.issn.2095-6606.2023.02.008
  中图分类号： R271
- 纸质出版日期：2023-03-30，
  
  收稿日期：2022-07-24，
- 稿件说明：
移动端阅览
张雅冬, 许昕. 多囊卵巢综合征证候特征与超声下卵巢形态学及血流动力学参数的相关性研究[J]. 现代中医临床, 2023,30(2):37-43.

ZHANG Yadong, XU Xin. Correlation between pattern features of polycystic ovary syndrome and ovarian morphological and hemodynamic parameters under ultrasonography[J]. Modern Chinese Clinical Medicine, 2023,30(2):37-43.
张雅冬, 许昕. 多囊卵巢综合征证候特征与超声下卵巢形态学及血流动力学参数的相关性研究[J]. 现代中医临床, 2023,30(2):37-43. DOI： 10.3969/j.issn.2095-6606.2023.02.008.

ZHANG Yadong, XU Xin. Correlation between pattern features of polycystic ovary syndrome and ovarian morphological and hemodynamic parameters under ultrasonography[J]. Modern Chinese Clinical Medicine, 2023,30(2):37-43. DOI： 10.3969/j.issn.2095-6606.2023.02.008.

摘要

目的

探讨多囊卵巢综合征(PCOS)证候特征与超声下卵巢形态学及血流动力学参数的相关性。

方法

将300例PCOS患者根据证候分为4组，肾虚组62例，脾虚痰湿组104例，肝郁血瘀组54例，阳明浊热组80例。采集患者一般资料，包括年龄、初潮年龄、病史、体质量指数(BMI)。经阴道或直肠进行超声检查，检测卵巢体积、卵泡数量及最大卵泡直径。选择卵巢髓质内最粗大动脉，检测其血流阻力指数(RI)和血流搏动指数(PI)。对4组PCOS患者年龄、初潮年龄、病史及BMI进行比较。对4组PCOS患者卵巢形态学特征进行比较，包括卵巢体积、卵泡数量、最大卵泡直径。对4组PCOS患者卵巢血流动力学特征进行比较，包括RI、PI。

结果

4组患者在年龄、初潮年龄及BMI方面比较，差异均无统计学意义(

0.05)。病史肾虚组较阳明浊热组缩短，差异有统计学意义(

0.05)。卵巢体积肾虚组较脾虚痰湿组、肝郁血瘀组、阳明浊热组均减小，差异均有统计学意义(

0.05)；肝郁血瘀组较脾虚痰湿组、阳明浊热组均减小，差异均有统计学意义(

0.05)；脾虚痰湿组与阳明浊热组比较，差异无统计学意义(

0.05)。卵泡数量肾虚组较脾虚痰湿组、阳明浊热组均减少，差异均有统计学意义(

0.05)，与肝郁血瘀组比较，差异无统计学意义(

0.05)；肝郁血瘀组较脾虚痰湿组、阳明浊热组均减少，差异均有统计学意义(

0.05)；脾虚痰湿组、阳明浊热组比较，差异无统计学意义(

0.05)。最大卵泡直径肾虚组较脾虚痰湿组、肝郁血瘀组、阳明浊热组均减小，差异均有统计学意义(

0.05)；脾虚痰湿组、肝郁血瘀组、阳明浊热组3组比较，差异均无统计学意义(

0.05)。卵巢RI、PI肾虚组较肝郁血瘀组、阳明浊热组均降低，差异均有统计学意义(

0.05)，较脾虚痰湿组升高，差异均有统计学意义(

0.05)；脾虚痰湿组较肝郁血瘀组、阳明浊热组均降低，差异均有统计学意义(

0.05)；肝郁血瘀组、阳明浊热组比较，差异均无统计学意义(

0.05)。

结论

4组PCOS患者卵巢形态学及血流动力学各有特点，可为中医临床辨证提供依据。

Abstract

Objective

To explore the correlation between the pattern features of polycystic ovary syndrome (PCOS) and ovarian morphological and hemodynamic parameters under ultrasonography.

Methods

A total of 300 patients with PCOS were assigned to 4 groups according to pattern identification

with 62 cases in the kidney deficiency (KD) group

104 cases in the spleen deficiency leading to phlegm dampness (SPPD) group

54 cases in the liver stagnation and blood stasis (LSBS) group and 80 cases in Yangming Zhuore group. General data of the patients were collected

including age

menarche age

medical history and body mass index (BMI). Ultrasonography was performed via the vagina or rectum to detect ovarian volume

follicle volume and maximum follicle diameter. The blood flow resistance index (RI) and blood flow pulsation index (PI) of the thickest artery in the ovarian medulla were measured. The age

menarche age

medical history and BMI in the 4 groups of PCOS patients were compared. The morphological characteristics of ovaries in 4 groups of PCOS patients were compared

including the ovarian volume

follicle volume

and maximum follicle diameter. The ovarian hemodynamic characteristics of 4 groups of PCOS patients were compared

including RI and PI.

Results

There was no significant difference in age

menarche age and BMI among the four groups (

0.05). The medical history was significantly shortened in the KD group than in the Yangming Zhuore group (

0.05). The ovarian volume was significantly smaller in the KD group than in the SPPD group

LSBS group

and Yangming Zhuore group (

0.05); the ovarian volume was significantly smaller in the LSBS group than in SPPD group and Yangming Zhuore group (

0.05); there was no significant difference between SPPD group and Yangming Zhuore group (

0.05). The follicle volume was significantly lower in the KD group than in the SPPD group and Yangming Zhuore group (

0.05); there was no significant difference as compared with LSBS group (

0.05); the follicle volume was significantly lower in the LSBS group than SPPD group and Yangming Zhuore group (

0.05); there was no significant difference between the SPPD group and Yangming Zhuore group (

0.05). The maximum follicle diameter was significantly smaller in the KD group than in the SPPD group

LSBS group

and Yangming Zhuore group (

0.05); there was no significance between the SPPD group

LSBS group and Yangming Zhuore group(

0.05). The RI and PI of the ovary were significantly lower in the KD group than in the LSBS group and Yangming Zhuore group (

0.05)

and significantly higher in the KD group than in the SPPD group (

0.05); the RI and PI of the ovary were significantly lower in the SPPD group than in the LSBS group and Yangming Zhuore group (

0.05); there was no significant difference between the LSBS group and Yangming Zhuore group (

0.05).

Conclusion

The ovarian morphology and hemodynamics of the 4 groups of PCOS patients have their own characteristics

which can provide reference for clinical pattern differentiation.

关键词

多囊卵巢综合征中医辨证超声卵巢参数

Keywords

polycystic ovary syndromeTCM syndrome differentiationultrasonographyovarian parameters

references

谢幸，孔北华，段涛.妇产科学[M].9版.北京：人民卫生出版社，2018: 348.

郭美运，姜晨蕾，张红娜.女性不孕患者多囊卵巢综合征患病率及临床特征的研究[J].实用妇科内分泌杂志(电子版)，2018,5(23): 26-30.

刘迎春，魏兆莲，徐玉萍，等.安徽省育龄妇女多囊卵巢综合征患病状况流行病学研究[J].生殖医学杂志，2011,20(3): 178-181.

郝翠芳.山东汉族育龄妇女PCOS发病和临床特点的相关性研究[D].济南：山东大学，2006: 25.

丁晓飞，周秋兰，梁晓雯，等.经阴道超声技术在多囊卵巢综合征诊断中的应用新进展[J]. 中国生育健康杂志，2022,33(1): 78-80.

张雅冬，许昕.从多囊卵巢综合征症状分析其病机[J].辽宁中医药大学学报，2013,15(9): 155-156.

张雅冬，许昕.不同证型多囊卵巢综合征与超声下卵巢参数的相关性研究[J].环球中医药，2018,11(7): 1018-1027.

张雅冬，许昕.许昕教授治疗妇科疾病经验[J].天津中医药，2019,36(12): 1196-1199.

ROTTERDAM ESHRE/ASRM-SPONSORED PCOS CONSENSUS WORKSHOP GROUP. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)[J]. Hum Reprod，2004,19(1): 41-47.

罗颂平.中医妇科学[M].3版.北京：人民卫生出版社，2016: 92.

中华中医药学会.中医妇科常见病诊疗指南[M].北京：中国中医药出版社，2012: 104-106.

中华医学会妇产科学分会内分泌学组及指南专家组.多囊卵巢综合征中国诊疗指南[J].中华妇产科杂志，2018,53(1): 2-6.

王雨婷.天津市宁河区中小学生月经初潮情况调查及相关因素分析[D].天津：天津医科大学，2019: 17.

孟宪芹，李金玉，赵丽萍，等.北京市大兴区多囊卵巢综合征患病情况调查及相关危险因素分析[J].中国妇幼保健，2021,36(24): 5764-5767.

丛晶，王顺，马红丽，等.青春期多囊卵巢综合征的特点及其中医治疗研究进展[J].现代中医临床，2019,26(6): 67-71.

詹妮，邓阿黎，李婷.姜惠中教授治疗多囊卵巢综合征临证经验[J].现代中西医结合杂志，2021,30(14): 1531-1535.

任梦雪，卫爱武.卫爱武教授治疗青春期多囊卵巢综合征经验撷箐[J].中医临床研究，2020,12(10): 87-89.

中国超重肥胖医学营养治疗专家共识编写委员会.中国超重/肥胖医学营养治疗专家共识[J].中华糖尿病杂志，2016,8(9): 525-540.

陈珊燕，赵颖.张玉珍运用“三补一攻”论治多囊卵巢综合征经验[J].中国中医药信息杂志，2020,27(4): 114-116.

陈士铎.石室秘录[M].柳璇，宋白杨，校注.北京：中国医药科技出版社，2019: 102.

陈丰.经阴道超声在多囊卵巢综合征诊断中的价值[J].世界最新医学信息文摘，2019,19(29): 7-8.

阮郑，寿炎明，田国琴，等.不同表现多囊卵巢综合征患者超声参数与内分泌指标的相关性研究[J].中国性科学，2016,25(5): 63-65.

杨新鸣，王淑言，邹红，等.多囊卵巢综合征“痰壅胞宫”的形态学特征[J].中医药信息，2011,28(5): 26-29.

钟淑娟，王颖金.彩色多普勒超声检查评估多囊卵巢综合征患者子宫内膜厚度及卵巢血流动力学的价值[J].实用临床医药杂志，2020,24(11): 32-39.

洪雪，王建凯.多囊卵巢综合征超声学血流动力诊断及其与性激素水平关系[J].中国计划生育学杂志，2021,29(12): 2704-2707.

陈奕男，秦将均.超声监测PCOS患者卵巢间质血流动力学变化及其与血清ES，VEGF的相关性分析[J].中国超声医学杂志，2021,37(4): 453-456.

刘艳丽，吕涛，尹科，等.多囊卵巢综合征的中医证型与超声指数的相关性分析[J].中医药导报，2014,20(14): 68-69.

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

多囊卵巢综合征从气论治探析

调泌针法治疗多囊卵巢综合征排卵障碍的临床研究

柴嵩岩“二阳致病”学术观点在多囊卵巢综合征论治中新解

郭志强教授运用“提壶揭盖”法治疗多囊卵巢综合征的经验

早期乳腺癌中医辨证内治专家共识