Drug pairs are the minimum fixed combination unit of the composition of traditional Chinese medicine(TCM) formulas

which can play a synergistic effect

reduce toxicity and side effects.Huangqin (Radix Scutellariae) and Zhizi (Fructus Gardeniae) are one of the representative drug pairs for clearing heat

purging fire and removing toxin

which are widely used in clinical scenarios.Each of the herbal ingredients used alone has the effect of clearing heat and draining fire

and combination of the two can drain fire and calm the heart

clear heat and purge the lung

remove toxin and protect the brain. In these ways

fire and heat in the upper

jiao

can be completely relmoved. In this paper

we systematically reviewed the cases of the combination of Huangqi and Zhizi in the treatment of upper

jiao

disorders

comprehensively analyzed the theoretical basis of the herbal pair

in order to expand the scope of its clinical application

and provide ideas for the study of drug pairs of traditional Chinese medicine.