Objective

2

To explore the distribution of main treatment syndromes

law of addition of herbal ingredients and dose-effect relationship of Gegen Qinlian Decoction (Pueraria Root

Scutellaria Root

and Coptis Decoction)

and to provide basis for modern application of the formula.

Methods

2

The main symptoms

prescription composition and dosage were collected from CNKI

Wanfang database and VIP database and statistically analyzed

and EXCEL was used to establish a database

and medication rule and dose-effect relationship were explored.

Results

2

Gegen Qinlian Decoction can be administered to both adults and children

the syndromes it can be used to treat were diarrhea (also in children) and diabetes

and the administration method mainly included oral administration and enema. When the medicine is ingested orally by adults

the herbal ingredients added to the original formula are

in descending order of frequency

Fuling (Poria)

Baizhu (Rhizoma Atractylodis Macrocephalae)

Muxiang (Radix Aucklandiae)

Baishao (Radix Paeoniae Alba)

and Chenpi (Pericarpium Citri Reticulatae)

etc.; for adult enema

Diyu (Radix Sanguisorbae)

Huaihua (Flos Sophorae)

Baishao (Radix Paeoniae Alba)

Baizhu (Rhizoma Atractylodis Macrocephalae)

and Baijiangcao (Herba Patriniae); for oral administration to children

Fuling (Poria)

Baizhu (Rhizoma Atractylodis Macrocephalae)

Cangzhu (Rhizoma Atractylodis)

Cheqianzi (Semen Plantaginis)

and Liushenqu (Massa Medicata Fermentata). Addition or reduction of these herbs are generally made as necessary. The most common version of the original formula consists of Gegen (Radix Puerariae Lobatae) 10-15 g (5-10 g in children)

Huangqin (Radix Scutellaria) 6-10 g (3-6 g in children)

Huanglian (Rhizoma Coptidis) 6-10 g (3-6 g in children)

Gancao (Radix et Rhizoma Glycyrrhizae) 6-10 g (2-6 g in children). There is a dose-effect relationship between the syndromes and dosage. In the treatment of type-2 diabetes

ulcerative colitis

acute gastroenteritis/acute enteritis

the usual dosage of Gegen was 30 g

10-15 g

10-15 g

respectively

Huangqin 12-20 g

6-10 g

6-10 g

Huanglian 6-10 g

6-10 g

6-10 g

and Gancao 5-15 g

6-10 g and 6 g. The most widely used ratio of the basic ingredients is currently 5∶3∶3∶2. The syndromes that it is effective for may vary according to different ratios between two herbs.

Conclusion

2

Analysis of medication rules and dose-effect relationship of Gegen Qinlian Decoction can provide basis for clinical practice and further pharmacological research.