针刺治疗手足综合征20例临床观察

杨泽佩; 胡凯文; 丁治国; 于梦芸; 梁翠梅; 杨文津; 安超

doi:10.3969/j.issn.2095-6606.2023.04.010

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针刺治疗手足综合征20例临床观察

临床研究 | 更新时间：2023-08-07

- 针刺治疗手足综合征20例临床观察
- Clinical study of acupuncture in the treatment of hand-foot syndrome
- 现代中医临床 2023年30卷第4期页码：49-52,61
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100029
  2.北京中医药大学东方医院
- 作者简介：
  
  杨泽佩，女，在读博士生
  # 安超，女，博士，副主任医师，硕士生导师，E-mail：annie_bucm@126.com
- 基金信息：
  
  高等学校学科创新引智计划项目(B21028)
- DOI：10.3969/j.issn.2095-6606.2023.04.010
  中图分类号： R246.5
- 纸质出版日期：2023-07-30，
  
  收稿日期：2022-10-13，
- 稿件说明：
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杨泽佩, 胡凯文, 丁治国, 等. 针刺治疗手足综合征20例临床观察[J]. 现代中医临床, 2023,30(4):49-52,61.

YANG Zepei, HU Kaiwen, DING Zhiguo, et al. Clinical study of acupuncture in the treatment of hand-foot syndrome[J]. Modern Chinese Clinical Medicine, 2023,30(4):49-52,61.
杨泽佩, 胡凯文, 丁治国, 等. 针刺治疗手足综合征20例临床观察[J]. 现代中医临床, 2023,30(4):49-52,61. DOI： 10.3969/j.issn.2095-6606.2023.04.010.

YANG Zepei, HU Kaiwen, DING Zhiguo, et al. Clinical study of acupuncture in the treatment of hand-foot syndrome[J]. Modern Chinese Clinical Medicine, 2023,30(4):49-52,61. DOI： 10.3969/j.issn.2095-6606.2023.04.010.

摘要

目的

观察针刺治疗手足综合征(hand-foot syndrome，HFS)的临床疗效。

方法

选取HFS患者20例，给予患者教育、穴位针刺(双侧)治疗3周。采用自身前后对照的研究方法，观察治疗前后的HFS疗效和分级、HFS症状评分、生活质量评分和安全性。

结果

治疗3周后，20例中治愈2例，有效12例，总有效14例，总有效率为70 %。HFS症状评分治疗后与治疗前比较，麻木感、针刺感、感觉迟钝、烧灼感、疼痛感、红斑、脱屑、色素沉着、肿胀评分均明显下降(

0.05)；EORTC QLQ-C30评分治疗后与治疗前比较，躯体功能、角色功能、情绪功能、社会功能、疲倦、疼痛、食欲减退、总体生命质量维度评分均明显提高(

0.05)。治疗中未出现严重不良反应。

结论

针刺治疗HFS有较好的临床疗效。

Abstract

Objective

To observe the clinical efficacy of acupuncture in the treatment of hand-foot syndrome (HFS).

Methods

20 patients with HFS were selected and given patient education and acupuncture (bilateral) for 3 weeks. Their efficacy and grading of HFS

HFS symptom scores

quality of life scores and safety were observed before and after treatment.

Results

After 3 weeks of treatment

2 cases were cured

12 cases were effective

and the total effective rate was 70%. After treatment

the scores of numbness

tingling sensation

insensitivity

burning sensation

pain

erythema

desquamation

pigmentation and swelling decreased significantly (

0.05). As for the EORTC QLQ-C30 score after treatment and before treatment

physical function

role function

emotional function

social function

fatigue

pain

loss of appetite

overall quality of life dimension scores were significantly improved (

0.05).

Conclusion

Acupuncture has a good clinical effect on HFS.

关键词

手足综合征针刺治疗肿瘤

Keywords

hand-foot syndromeacupuncturetreatmentcancer

references

LACOUTURE M E，SIBAUD V，GERBER P A，et al. Prevention and management of dermatological toxicities related to anticancer agents: ESMO clinical practice guidelines [J]. Ann of Oncol，2021,32(2):157-170.

DEGEN A，ALTER M，SCHENCK F，et al. The hand-foot-syndrome associated with medical tumor therapy － classification and management [J]. JDDG，2010,8(9):652-661.

YAP Y S，KWOK L L，SYN N，et al. Predictors of hand-foot syndrome and pyridoxine for prevention of capecitabine-induced hand-foot syndrome: a randomized clinical trial [J]. JAMA Oncol，2017,3(11):1538-1545.

SUZUKI S，NAWATA S，INADA Y，et al. A cross-sectional survey of methods for controling hand-foot syndrome in patients receiving capecitabine treatment[J]. Mol Clin Oncol，2018,9(4):443-448.

SON H S，LEE W Y，LEE W S，et al. Compliance and effective management of the hand-foot syndrome in colon cancer patients receiving capecitabine as adjuvant chemotherapy [J]. Yonsei Med J，2009,50(6):796-802.

UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES. Common terminology criteria for adverse events (CTCAE) [EB/OL].[2022-08-06].https://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdfhttps://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf.

娄彦妮，陈信义，田爱平，等.通络活血法外用治疗化疗性手足综合征临床研究[J]. 辽宁中医药大学学报，2013,15(4):68-70.

朱孝娟，李杰.参草手足润肤膏治疗手足综合征随机双盲对照试验临床观察[J].中华中医药杂志，2019,34(8):3825-3828.

万崇华，陈明清，张灿珍，等.癌症患者生命质量测定量表EORTC QLQ-C30中文版评介[J].实用肿瘤杂志，2005,20(4):353-355.

李中梓.医宗必读[M].郭霞珍，王志飞，袁卫玲，等，整理.北京：人民卫生出版社，2006: 277.

李志明，李仝，胡凯文，等.加味仙方活命饮防治卡培他滨相关性手足综合征疗效观察[J].辽宁中医药大学学报，2020,22(5):62-66.

武敏，黄传兵，王鹏飞，等.补阳还五汤化裁治疗气虚血瘀型手足综合征[J].中医学报，2023,38(5):1082-1087.

杨泽佩，田桢，鲍伟倩，等.益元通络法针刺治疗手足综合征的临床经验[J].中华中医药杂志，2020,35(6):2932-2935.

张晟星，戚淦.经穴释义汇解[M].上海：上海翻译出版公司，1984: 308.

杨继洲.针灸大成[M].李勤璞，俞晓旸，点校.北京：中华书局，2017: 209.

STAROBOVA H，VETTER I. Pathophysiology of chemotherapy-induced peripheral neuropathy[J/OL]. Front Mol Neurosci,2017,10:174[2022-08-06]. https://www.frontiersin.org/articles/10.3389/fnmol.2017.00174/fullhttps://www.frontiersin.org/articles/10.3389/fnmol.2017.00174/full.

ZIJLSTRA F J，VANDENBERG-DELANGE I，HUYGEN F J，et al. Anti-inflammatory actions of acupuncture[J]. Mediators Inflamm，2003,12(2):59-69.

LE J J，YI T，QI L，et al. Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression [J/OL]. Neuroscience Letters,2016,615:66-71[2022-08-06]. https://www.sciencedirect.com/science/article/abs/pii/S0304394016300040？via%3Dihubhttps://www.sciencedirect.com/science/article/abs/pii/S0304394016300040？via%3Dihub.

陈孟，邓明.针灸联合药物治疗胃肠肿瘤化疗患者胃肠道反应疗效观察[J]. 现代中西医结合杂志，2016,25(15):1664-1666.

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