许昕调治卵巢功能减退42例临床观察及用药分析

徐鸿燕; 许昕(指导)

doi:10.3969/j.issn.2095-6606.2023.05.003

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许昕调治卵巢功能减退42例临床观察及用药分析

临床研究 | 更新时间：2023-10-12

- 许昕调治卵巢功能减退42例临床观察及用药分析
- Clinical observation and prescription analysis of 42 cases of hypoovarianism treated by Xu Xin
- 现代中医临床 2023年30卷第5期页码：10-16
- 作者机构：
  
  首都医科大学附属北京中医医院　北京　100010
- 作者简介：
  
  徐鸿燕，女，硕士，副主任医师
- 基金信息：
  
  北京市属医院科研培育计划项目(PZ2020018)
- DOI：10.3969/j.issn.2095-6606.2023.05.003
  中图分类号： R271.9
- 纸质出版日期：2023-09-30，
  
  收稿日期：2023-02-10，
- 稿件说明：
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徐鸿燕, 许昕(指导). 许昕调治卵巢功能减退42例临床观察及用药分析[J]. 现代中医临床, 2023,30(5):10-16.

XU Hongyan, XU Xin(Tutor). Clinical observation and prescription analysis of 42 cases of hypoovarianism treated by Xu Xin[J]. Modern Chinese Clinical Medicine, 2023,30(5):10-16.
徐鸿燕, 许昕(指导). 许昕调治卵巢功能减退42例临床观察及用药分析[J]. 现代中医临床, 2023,30(5):10-16. DOI： 10.3969/j.issn.2095-6606.2023.05.003.

XU Hongyan, XU Xin(Tutor). Clinical observation and prescription analysis of 42 cases of hypoovarianism treated by Xu Xin[J]. Modern Chinese Clinical Medicine, 2023,30(5):10-16. DOI： 10.3969/j.issn.2095-6606.2023.05.003.

摘要

目的

分析总结许昕调治卵巢功能减退的用药及机理，并进行疗效分析。

方法

选取许昕治疗卵巢功能减退的病例42例，根据严重程度，以月经第2天血液激素检测卵泡期的卵泡刺激素(FSH)值，将病例分为2组：卵巢储备功能下降(DOR)组21例和早发性卵巢功能不全及卵巢功能衰竭(POI/POF)组21例。患者仅服用中药汤剂治疗，日1剂，200 mL，分2次服，经期不用药。观察2类患者治疗前后的孕产情况，月经情况、基础体温(BBT)、女性激素、卵巢体积、开始起效时间等，进而分析许昕调治卵巢功能用药及机理。

结果

治疗后DOR组有10例患者受孕并全部顺利分娩；POI/POF组有4例患者受孕，其中3例顺利分娩，1例因个人原因终止妊娠。DOR组患者月经均恢复正常；POI/POF组有12例月经复常，占57.14%。DOR组患者BBT均呈双相改变；POI/POF组患者有15例BBT呈双相改变，占75%。2组患者的FSH、促黄体生成素(LH)均有下降，下降程度有明显差异；E

均有一定程度升高，其中，POI/POF组患者的E

升高幅度有统计学意义。治疗后患者的卵巢体积可有一定程度增大，其中POI/POF组患者的右侧卵巢体积在治疗前萎缩最为明显，治疗后体积增加最为明显，差异具有统计学意义(

0.05)。

结论

许昕以中药调治卵巢功能减退，有助于帮助患者孕产，并让月经恢复规律，基础体温和性激素也有一定的恢复。通过补肾、化浊、调畅气血，可以改善卵巢功能减退患者的月经情况、恢复卵巢功能、促进排卵、提高妊娠率和活产率，同时有可能改变血清学与卵巢形态学指标，即下调FSH、LH水平，升高E

水平，可能促使缩小的卵巢体积增加。

Abstract

Objective

To analyze and summarize the prescriptions and mechanism of Dr. Xu Xin in the treatment of hypoovarianism

and make further analysis of clinical efficacy.

Methods

42 cases of hypoovarianism treated by Dr. Xu Xin were selected. According to the severity

the FSH value in the follicular phase was measured by the female hormone on the second day of menstruation. The cases were divided into two groups: 21 cases in the decreased ovarian reserve (DOR) group and 21 in the premature ovarian insufficiency and ovarian failure (POI/POF) group. The patient was treated with traditional Chinese medicine decoctions only

one dose per day

200 ml

divided into two portions

to be consumed within one day. In addition

no drug was taken during the menstrual period. The pregnancy and childbirth

menstrual status

basal body temperature (BBT)

female hormone

ovarian volume

and time onset of action of the two groups were observed

and then the prescriptions and mechanism of Dr. Xu Xin’s treatment were analyzed.

Results

After the treatment

10 patients in DOR group were pregnant and gave birth successfully; in the POI/POF group

4 were pregnant

of which 3 gave birth successfully

and 1 terminated her pregnancy due to personal reasons. The menstruation of the patients in DOR group returned to normal; in POI/POF group

12 cases (57.14%) had normal menstruation. BBT in DOR group showed biphasic changes; in the POI/POF group

15 patients (75%) showed biphasic changes in BBT. The levels of FSH and LH in the two groups decreased significantly; E

increased to a certain extent. The increase of E

in the POI/POF group was statistically significant. After the treatment

the ovarian volume of patients can be increased to a certain extent. The right ovaries of patients in POI/POF group had shrunk most significantly before treatment

and increased in volume most significantly after the treatment

and the statistical data suggested that it was statistically significant.

Conclusion

Dr. Xu Xin’s gynecological treatment of hypoovarianism is helpful for pregnancy and childbirth

and for restoring the regularity of menstruation. Recovery was also evident in the patients’ basic body temperature and female hormone. By tonifying the kidney

removing turbidity

and restoring the free movement of qi and blood

the herbs can improve the menstrual status of the patients

restore ovarian function

promote ovulation

improve pregnancy rate and live birth rate

and may improve the serological and ovarian morphological indicators

by reducing the level of FSH and LH

and increasing the level of E

increase the size of the shrunken ovaries.

关键词

许昕卵巢功能中医药疗效分析

Keywords

Xu Xinovarian functiontraditional Chinese medicineefficacy analysis.

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