补肾活血化浊方联合驱铜治疗肝肾亏虚、痰瘀互结证Wilson病患者肌张力障碍临床观察

黄晓峰; 陈宏; 张娟; 王谢; 杨波; 周磊; 张荣信

doi:10.3969/j.issn.2095-6606.2023.05.006

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补肾活血化浊方联合驱铜治疗肝肾亏虚、痰瘀互结证Wilson病患者肌张力障碍临床观察

临床研究 | 更新时间：2023-10-12

- 补肾活血化浊方联合驱铜治疗肝肾亏虚、痰瘀互结证Wilson病患者肌张力障碍临床观察
- Clinical observation on the treatment of dystonia in Wilson’s disease patients with deficiency of liver and kidney, binding of phlegm and stasis through the combined use of Bushen Huoxue Huazhuo Formula and anti-copper therapies
- 现代中医临床 2023年30卷第5期页码：30-34,52
- 作者机构：
  
  1.安徽中医药大学第一附属医院　合肥　230031
  2.安徽中医药大学
- 作者简介：
  
  黄晓峰，男，硕士，主治医师
  # 张娟，女，博士，教授、主任医师，博士生导师，E-mail：1477210980@qq.com。
- 基金信息：
  
  国家自然科学基金资助项目(82274493;81774299);中华民族医药学会科研项目(2020ZY070－410033)
- DOI：10.3969/j.issn.2095-6606.2023.05.006
  中图分类号： R259
- 纸质出版日期：2023-09-30，
  
  收稿日期：2022-09-28，
- 稿件说明：
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黄晓峰, 陈宏, 张娟, 等. 补肾活血化浊方联合驱铜治疗肝肾亏虚、痰瘀互结证Wilson病患者肌张力障碍临床观察[J]. 现代中医临床, 2023,30(5):30-34,52.

HUANG Xiaofeng, CHEN Hong, ZHANG Juan, et al. Clinical observation on the treatment of dystonia in Wilson’s disease patients with deficiency of liver and kidney, binding of phlegm and stasis through the combined use of Bushen Huoxue Huazhuo Formula and anti-copper therapies[J]. Modern Chinese Clinical Medicine, 2023,30(5):30-34,52.
黄晓峰, 陈宏, 张娟, 等. 补肾活血化浊方联合驱铜治疗肝肾亏虚、痰瘀互结证Wilson病患者肌张力障碍临床观察[J]. 现代中医临床, 2023,30(5):30-34,52. DOI： 10.3969/j.issn.2095-6606.2023.05.006.

HUANG Xiaofeng, CHEN Hong, ZHANG Juan, et al. Clinical observation on the treatment of dystonia in Wilson’s disease patients with deficiency of liver and kidney, binding of phlegm and stasis through the combined use of Bushen Huoxue Huazhuo Formula and anti-copper therapies[J]. Modern Chinese Clinical Medicine, 2023,30(5):30-34,52. DOI： 10.3969/j.issn.2095-6606.2023.05.006.

摘要

目的

通过研究自拟方补肾活血化浊方联合驱铜治疗，探讨对Wilson病肝肾亏虚、痰瘀互结证患者肌张力障碍的改善情况。

方法

将60例肝肾亏虚、痰瘀互结型Wilson病合并肌张力障碍患者采用完全随机分组，分为对照组、补肾活血化浊方组、二巯丙磺酸钠(Sodium Dimercaptosulphonate

DMPS)组、补肾活血化浊方联合DMPS组，每组15例，除对照组予安慰剂治疗，其余各组均予相应的药物治疗，将治疗前与治疗4周后UWDRS评分Ⅲ(神经功能)、Ashworth 量表评分、BFM 评分及中医证候积分进行比较，采用 SPSS 23.0统计软件进行统计学分析，对4组患者的疗效进行评定。

结果

将各组患者治疗前Uwdrs评分Ⅲ(神经功能)、Ashworth 量表评分、BFM 评分及中医证候积分进行比较，差异无明显统计学意义(

0.05)，对照组治疗前后各项积分变化与治疗前无明显差异(

0.05)，补肾活血化浊方组、DMPS组、补肾活血化浊方联合DMPS组治疗前后各项评分均有所下降(

0.05)，其中以补肾活血化浊方联合DMPS组评分降低更为明显，差异有统计学意义(

0.01)。

结论

补肾活血化浊方联合驱铜可以显著改善肝肾亏虚、痰瘀互结证Wilson病患者肌张力障碍，可为临床上中西医结合治疗Wilson病肌张力障碍提供一定的参考。

Abstract

Objective

By studying Bushen Huoxue Huazhuo Formula (补肾活血化浊

literally meaning Kidney-Tonifying

Blood-Activating and Turbidity-Resolving Formula

BSHXHZF)

an original TCM prescription

administered in combination with anti-copper treatment

we further explored the improvement of dystonia in patients with Wilson’s disease and the TCM pattern of deficiency of liver and kidney

binding of phlegm and stasis.

Methods

60 patients with Wilson’s disease and dystonia of the pattern of deficiency of liver and kidney and binding of phlegm and stasis were randomly divided into the control group

the BSHXHZF group

the DMPS group

and the BSHXHZF + DMPS group

with 15 in each. The control group was given a placebo

and the other groups were given the corresponding medications

and the UWDRS scores of the patients before and after the treatment period of 4 weeks were compared. The UWDRS score III (neurological function)

Ashworth scale score

BFM score and TCM syndrome score were compared before and after the treatment

and the efficacy of the four groups was evaluated by using SPSS 23.0 for statistical analysis.

Results

Uwdrs score III (neurological function)

Ashworth scale score

BFM score and TCM syndrome score were compared among the patients in each group before treatment

and the differences were not statistically significant (

0.05)

and there was no significant difference between the changes in the scores of the control group before and after treatment (

0.05)

and there was no significant difference between the scores of the BSHXHZF group the DMPS group

and the BSHXHZF + DMPS group before and after treatment. The scores of these three groups decreased after treatment (

0.05)

among which the scores of the BSHXHZF + DMPS group decreased even more significantly

and the difference was statistically significant (

0.01).

Conclusion

The combined use of BSHXHZF and anti-copper therapies can significantly improve the dystonia in Wilson’s disease patients with deficiency of liver and kidney and binding of phlegm and stasis

which can provide reference for the treatment of dystonia in patients with Wilson’s disease with the combination of traditional Chinese and Western medicine in the clinical practice.

关键词

补肾活血化浊方驱铜Wilson病肌张力障碍中医治疗

Keywords

Bushen Huoxue Huazhuo Formulacopper dischargeWilson’s diseasedystoniatraditional Chinese medicine treatment

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