阈下抑郁静息态功能脑网络的拓扑属性及芳香疗法作用机制

林丹; 高金阳; 谭中健; 韩笑; 王芳; 周莉; 崔方圆

doi:10.3969/j.issn.2095-6606.2023.06.003

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阈下抑郁静息态功能脑网络的拓扑属性及芳香疗法作用机制

临床研究 | 更新时间：2023-12-08

- 阈下抑郁静息态功能脑网络的拓扑属性及芳香疗法作用机制
- Topological properties and aromatherapy mechanisms of resting-state functional brain networks in subthreshold depression
- 现代中医临床 2023年30卷第6期页码：12-16
- 作者机构：
  
  1.北京中医药大学针灸推拿学院　　北京　102401
  2.北京中医药大学东直门医院
- 作者简介：
  
  林丹，女，在读博士生
  #崔方圆，女，博士，副主任医师，硕士生导师，E-mail: xmly2015@126.com
- 基金信息：
  
  国家自然科学基金青年基金项目(8200151376)
- DOI：10.3969/j.issn.2095-6606.2023.06.003
  中图分类号： R259
- 纸质出版日期：2023-11-30，
  
  收稿日期：2022-12-15，
- 稿件说明：
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林丹, 高金阳, 谭中健, 等. 阈下抑郁静息态功能脑网络的拓扑属性及芳香疗法作用机制[J]. 现代中医临床, 2023,30(6):12-16.

LIN Dan, GAO Jinyang, TAN Zhongjian, et al. Topological properties and aromatherapy mechanisms of resting-state functional brain networks in subthreshold depression[J]. Modern Chinese Clinical Medicine, 2023,30(6):12-16.
林丹, 高金阳, 谭中健, 等. 阈下抑郁静息态功能脑网络的拓扑属性及芳香疗法作用机制[J]. 现代中医临床, 2023,30(6):12-16. DOI： 10.3969/j.issn.2095-6606.2023.06.003.

LIN Dan, GAO Jinyang, TAN Zhongjian, et al. Topological properties and aromatherapy mechanisms of resting-state functional brain networks in subthreshold depression[J]. Modern Chinese Clinical Medicine, 2023,30(6):12-16. DOI： 10.3969/j.issn.2095-6606.2023.06.003.

摘要

目的

分析阈下抑郁(SD)患者静息态功能脑网络拓扑属性改变，探究芳香疗法作用于SD患者的机制。

方法

选取SD患者35例，相匹配的健康对照组35例，剔除脱落受试者后，SD组30例，健康对照组30例。2组均接受15～20 min芳香疗法干预。采集贝克抑郁自评量表(BDI)评分、小世界属性参数值、网络效率值、度中心性(DC)值。

结果

干预后2组BDI量表评分均较干预前降低，差异有统计学意义(

0.05)，SD组降低更明显，差异有统计学意义(

0.05)。2组在0.05≤稀疏度≤0.40内，均表现为经济高效的小世界网络(σ

1)。2组干预前，SD组较健康对照组相比，Lp、λ值显著升高，σ值显著降低，差异有统计学意义(

0.05)。干预后SD组在左侧额下回区域DC值增加(

0.001)，在运动前皮层和补充运动区区域，DC值显著减少(

0.001)。

结论

SD患者静息态脑功能网络小世界属性降低，芳香疗法可改善负性情绪，其机制可能与协调脑区间活动有关。

Abstract

Objective

To analyze the topological properties of functional brain network at the resting state in patients with subthreshold depression (SD)

and explore the mechanism of aromatherapy in SD patients.

Methods

A total of 35 SD patients and 35 healthy controls were selected. After removing shedding subjects

30 SD patients and 30 healthy controls were selected. Both groups received aromatherapy intervention for 15 to 20 min. BDI scale score

small-world attribute parameter value

network efficiency value

degree centrality value were collected.

Results

After intervention

the score of BDI scale in both groups was lower than that before intervention

the difference was statistically significant (

0.05)

and the decrease was more obvious in SD group

the difference was statistically significant (

0.05). In the range of 0.05 ≤ sparsity ≤0.40

the two groups are all economically efficient small-world networks (

1). Before intervention

Lp and λ values in SD group were significantly higher than those in the control group

while σvalues were significantly lower

with statistical significance (

0.05). After intervention

the DC value of SD group increased in the left inferior frontal gyrus region (

0.001)

and significantly decreased in the premotor cortex and supplementary motor area region (

0.001).

Conclusion

In SD patients

the small world attribute of the resting-state brain functional network is reduced. Aromatherapy can improve negative emotions

and the mechanism may be related to the coordination of brain region activities.

关键词

阈下抑郁脑网络小世界芳香疗法

Keywords

subthreshold depressionbrain networksmall worldaromatherapy

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