Objective A new safety and effective therapeutics method for hypoxic-ischemic encephalopathy （HIE） was detected. Method On the basis of expectant

supporting treatment of HIE

the cases were given 10～20 ml Shengmai Injection by iv or im after dilution with qd once a day. The first injunction was given without dilution within one hour after admission. One course of treatment included seven days

serious patients could be treated for two or three courses. Result The effective rate of serious patients in the treatment group was distinctively higher than that of the control group

while the unfavorable prognosis rate in the treatment group was distinctively lower （P<0.05）. The duration of clinical symptoms in the treatment group was shorter （P<0.05）. The results of the statistics showed that there was significant difference. Conclusion Early treatment of HIE with Shengmai Injection with full dose could prevent the brain from injury after asphyxia

blockage effectively the development of HIE

prevent the hypoxic-ischemic myocardial damage

abate the symptoms of nervous system; shorten the course of treatment ; reduce the death and disablement rate and raise the life quality of the patient.