大蒜素治疗急性脑梗塞的临床观察

张久亮; 刘鑫; 毛建生; 史载祥

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大蒜素治疗急性脑梗塞的临床观察

更新时间：2021-09-15

- 大蒜素治疗急性脑梗塞的临床观察
- Clinical Observation on Treatment of Acute Brain Infarction with Allicin
- 北京中医药大学学报(中医临床版) 2003年0卷第2期页码：23-26
- 作者机构：
  
  1. 中日友好医院中医心肾科
  2. 中日友好医院中医心肾科,北京,100029
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R277.7
- 纸质出版日期：2003，
- 稿件说明：
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张久亮, 刘鑫, 毛建生, 等. 大蒜素治疗急性脑梗塞的临床观察[J]. 北京中医药大学学报(中医临床版), 2003,0(2):23-26.

Zhang Jiuliang, Liu Xin, Mao Jiansheng. Clinical Observation on Treatment of Acute Brain Infarction with Allicin[J]. Modern Chinese Clinical Medicine, 2003,0(2):23-26.
张久亮, 刘鑫, 毛建生, 等. 大蒜素治疗急性脑梗塞的临床观察[J]. 北京中医药大学学报(中医临床版), 2003,0(2):23-26. DOI：

Zhang Jiuliang, Liu Xin, Mao Jiansheng. Clinical Observation on Treatment of Acute Brain Infarction with Allicin[J]. Modern Chinese Clinical Medicine, 2003,0(2):23-26. DOI：

摘要

目的　观察大蒜素治疗急性脑梗塞临床治疗效果

并探讨大蒜素治疗急性脑梗塞的机制。方法　选用发病 3d以内的急性脑梗塞患者 5 5例

随机分为大蒜素治疗组及川芎嗪对照组

观察临床治疗效果及血清丙二醛 (MDA)含量的动态变化。结果　治疗 2周时大蒜素组及川芎嗪组的有效率分别是为 75 76 %、6 4 6 4 %

治疗 4周时为 86 96 %、76 4 7%

同步比较无差异 (P >0 0 5 ) ;治疗 4周时大蒜素组神经缺损分数的改善是 (10 0 0± 5 5 9)

川芎嗪组 (6 18± 4 32 ) (P <0 0 5 ) ;急性脑梗塞患者血清MDA含量明显高于健康人 (P <0 0 1)

大蒜素组MDA含量逐渐下降

治疗 3周时明显低于川芎嗪组 (P <0 0 1)。结论　大蒜素对急性脑梗塞具有较好的治疗效果

其作用机理是 :大蒜素可有效地清除自由基

减轻脑缺血—再灌流损伤。

Abstract

Objective To Observe the curative effect of acute brain infarction （ABI） with allincin and discuss the mechanism of treatment of ABI with allicin. Method Fifty-five cases of ABI

whose illnesses were onset within 3 days

were divided randomly into allicin group and the control group with ligustrazine. The curative effects and dynamic changes of serum MDA content in two groups were observed. Result After 2-week treatment the effective rate in allicin group was 75.76%

control group

64.64%. After 4-week treatment the effective rate in allicin group was 86.96%

the control group

76.47%. There was no difference （P>0.05）. After 4-week treatment the improvement of grade of nerve injuries in allicin group was 10.00±5.59

in the control group

6.18±4.32 （P<0.05）. Patients of ABI had higher serum MDA content than normal people （P<0.01）. After 3-week treatment the cases in allicin group had a gradually decline in MDA content

which obviously lowered than the control group （P<0.01）. Conclusion Allicin had good curative effect on ABI. The mechanism of it was to clear away free radical

lighten the injury of cerebral ischemia and reperfusion.

关键词

大蒜素急性脑梗塞丙二醛

Keywords

allicinacute brain infarctionmalondialdehyde （MDA）

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